(5Z)-1-(2-chlorophenyl)-5-(1-hydroxyethylidene)-2-(4-methoxyphenyl)-2H-pyridin-6-one | 1426584-27-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (5Z)-1-(2-chlorophenyl)-5-(1-hydroxyethylidene)-2-(4-methoxyphenyl)-2H-pyridin-6-one
• CAS: 1426584-27-1
• 化学式: C₂₀H₁₈ClNO₃
• 分子量: 355.821
• InChiKey: INPBHGWIIWWDJZ-SSZFMOIBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-acetyl-N-(2-chlorophenyl)-5-(4-methoxyphenyl)penta-2,4-dienamide 以 5,5-dimethyl-1,3-cyclohexadiene 为溶剂， 生成 (5Z)-1-(2-chlorophenyl)-5-(1-hydroxyethylidene)-2-(4-methoxyphenyl)-2H-pyridin-6-one 、 (5E)-1-(2-chlorophenyl)-5-(1-hydroxyethylidene)-2-(4-methoxyphenyl)-2H-pyridin-6-one
  参考文献：
  名称：

  Hydrogen Bond-Assisted 6π-Azaelectrocyclization of Penta-2,4-dienamides: Synthesis of Dihydropyridin-2(3H)-ones

  摘要：

  A facile and efficient synthesis of substituted dihydropyridin-2(3H)-ones is developed from penta-2,4-dienamides, in which an intramolecular C-N bond was formed through thermal 6 pi-azaelectrocyclization. The intra-molecular hydrogen bonding-assisted cyclization reaction opens access to a variety of dihydropyridin-2(3H)-ones.

  DOI：

  10.1021/jo4001959

文献信息

• Hydrogen Bond-Assisted 6π-Azaelectrocyclization of Penta-2,4-dienamides: Synthesis of Dihydropyridin-2(3<i>H</i>)-ones
  作者：Xu Liu、Ning Zhang、Jiming Yang、Yongjiu Liang、Rui Zhang、Dewen Dong

  DOI：10.1021/jo4001959

  日期：2013.4.5

  A facile and efficient synthesis of substituted dihydropyridin-2(3H)-ones is developed from penta-2,4-dienamides, in which an intramolecular C-N bond was formed through thermal 6 pi-azaelectrocyclization. The intra-molecular hydrogen bonding-assisted cyclization reaction opens access to a variety of dihydropyridin-2(3H)-ones.