2-[(1E)-4-trimethylsilylbut-1-en-3-ynyl]furan | 893413-74-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: 2-[(1E)-4-trimethylsilylbut-1-en-3-ynyl]furan
• 英文别名: [(E)-4-(furan-2-yl)but-3-en-1-ynyl]-trimethylsilane
• CAS: 893413-74-6
• 化学式: C₁₁H₁₄OSi
• 分子量: 190.317
• InChiKey: KHHOJLFOTMDFGV-QPJJXVBHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.17
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  13.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-[(1E)-4-trimethylsilylbut-1-en-3-ynyl]furan 在 四(三苯基膦)钯 甲醇 、 potassium carbonate 、 二异丙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 71.0h， 生成 2-[(1E)-non-1-ene-3,5,7-triynyl]furan
  参考文献：
  名称：

  Synthesis of naturally occurring polyacetylenes via a bis-silylated diyne

  摘要：

  A straightforward synthesis of a series of naturally occurring polyacetylenes has been developed, including the montiporynes A C ells, the atractylodin, with antibiotic at and C, possessing cytotoxic activity against several human solid tumor c activity against Escherichia coli, and triynes, which display insecticidal activities, starting from the readily available 1,4-bis(trimethylsilyl)-1,3-butadiyne. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2006.03.043
• 作为产物：
  描述：

  2-(2-bromovinyl)furan 、 三甲基乙炔基硅 在 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以65%的产率得到2-[(1E)-4-trimethylsilylbut-1-en-3-ynyl]furan
  参考文献：
  名称：

  Synthesis of naturally occurring polyacetylenes via a bis-silylated diyne

  摘要：

  A straightforward synthesis of a series of naturally occurring polyacetylenes has been developed, including the montiporynes A C ells, the atractylodin, with antibiotic at and C, possessing cytotoxic activity against several human solid tumor c activity against Escherichia coli, and triynes, which display insecticidal activities, starting from the readily available 1,4-bis(trimethylsilyl)-1,3-butadiyne. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2006.03.043

文献信息

• Synthesis of naturally occurring polyacetylenes via a bis-silylated diyne
  作者：Vito Fiandanese、Daniela Bottalico、Giuseppe Marchese、Angela Punzi

  DOI：10.1016/j.tet.2006.03.043

  日期：2006.5

  A straightforward synthesis of a series of naturally occurring polyacetylenes has been developed, including the montiporynes A C ells, the atractylodin, with antibiotic at and C, possessing cytotoxic activity against several human solid tumor c activity against Escherichia coli, and triynes, which display insecticidal activities, starting from the readily available 1,4-bis(trimethylsilyl)-1,3-butadiyne. (c) 2006 Elsevier Ltd. All rights reserved.