6-(5-methyl-2-oxoimidazolidin-4-yl)hexanoic acid | 218953-39-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 6-(5-methyl-2-oxoimidazolidin-4-yl)hexanoic acid
• 英文别名: 6-[(5S)-5-methyl-2-oxoimidazolidin-4-yl]hexanoic acid
• CAS: 218953-39-0
• 化学式: C₁₀H₁₈N₂O₃
• 分子量: 214.265
• InChiKey: AUTOLBMXDDTRRT-JAMMHHFISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  78.4
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  三光气 、 7,8-diaminononanoic acid methyl ester dihydrochloride 在 sodium hydroxide 作用下， 生成 6-(5-methyl-2-oxoimidazolidin-4-yl)hexanoic acid
  参考文献：
  名称：

  The Synthesis of the Vitamers of Biotin

  摘要：

  An efficient synthetic pathway for the preparation of the vitamers of biotin which provides easy access to optically pure KAPA as well as diastereomeric mixtures of DAPA, DTB, and analogs thereof has been developed. (C) 1998 Academic Press.

  DOI：

  10.1006/bioo.1998.1094

文献信息

• QUINONE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF
  申请人：Kelley Mark R.

  公开号：US20100297113A1

  公开（公告）日：2010-11-25

  This application describes quinone derivatives which target the redox site of Ape1/Ref1. Also included in the invention are pharmaceutical formulations containing the derivatives and therapeutic uses of the derivatives.

  这个应用描述了目标为Ape1/Ref1的氧化还原位点的醌衍生物。发明还包括含有这些衍生物的药物制剂和这些衍生物的治疗用途。
• US9089605B2
  申请人：——

  公开号：US9089605B2

  公开（公告）日：2015-07-28
• The Synthesis of the Vitamers of Biotin
  作者：Abraham Nudelman、Ayelet Nudelman、Dana Marcovici-Mizrahi、Dennis Flint

  DOI：10.1006/bioo.1998.1094

  日期：1998.10

  An efficient synthetic pathway for the preparation of the vitamers of biotin which provides easy access to optically pure KAPA as well as diastereomeric mixtures of DAPA, DTB, and analogs thereof has been developed. (C) 1998 Academic Press.