(-)(3S)-2,3-Dimethyl-pentansaeure-methylester | 1195338-87-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (-)(3S)-2,3-Dimethyl-pentansaeure-methylester
• 英文别名: methyl (3S)-2,3-dimethylpentanoate
• CAS: 1195338-87-4
• 化学式: C₈H₁₆O₂
• 分子量: 144.214
• InChiKey: YSXGGWIXNLJFTM-PKPIPKONSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (-)(3S)-2,3-Dimethyl-pentansaeure-methylester 在 lithium aluminium tetrahydride 、 三溴化磷 作用下， 生成 (+)(3S)-1-Brom-2.3-dimethyl-pentan
  参考文献：
  名称：

  Preparation of -(3S)-2,3-dimethylpentanal by reaction of (+)-tris[(2S)-1,2-dimethylbutoxy]methane (I) with carbon monoxide and hydrogen

  摘要：

  DOI：

  10.1021/jo01278a084
• 作为产物：
  描述：

  重氮甲烷 、 一氧化碳 、 (+)-Tris-<(2S)-1,2-dimethyl-butyloxy>-methan 生成 (+)-(S)-methyl 4-methylhexanoate 、 (-)(3S)-2,3-Dimethyl-pentansaeure-methylester
  参考文献：
  名称：

  Preparation of -(3S)-2,3-dimethylpentanal by reaction of (+)-tris[(2S)-1,2-dimethylbutoxy]methane (I) with carbon monoxide and hydrogen

  摘要：

  DOI：

  10.1021/jo01278a084

文献信息

• TRPM8 ANTAGONISTS AND THEIR USE IN TREATMENTS
  申请人：BROWN James

  公开号：US20130158034A1

  公开（公告）日：2013-06-20

  Compounds of Formula I are useful as antagonists of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.

  式I的化合物是TRPM8拮抗剂，对于治疗许多TRPM8介导的疾病和症状有用，并可用于制备治疗此类疾病和症状的药物和制剂。此类疾病的例子包括但不限于偏头痛和神经病性疼痛。式I的化合物具有以下结构：其中变量的定义在此提供。
• Rossi,R. et al., Gazzetta Chimica Italiana, 1967, vol. 97, p. 1194 - 1208
  作者：Rossi,R. et al.

  DOI：——

  日期：——
• US8778941B2
  申请人：——

  公开号：US8778941B2

  公开（公告）日：2014-07-15
• [EN] NOVEL 6-FUSED HETEROARYLDIHYDROPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION<br/>[FR] NOUVELLES HÉTEROARYLDIHYDROPYRIMIDINES CONDENSÉES EN POSITION 6 POUR LE TRAITEMENT ET LA PROPHYLAXIE D'UNE INFECTION À VIRUS DE L'HÉPATITE B
  申请人：HOFFMANN LA ROCHE

  公开号：WO2015132276A1

  公开（公告）日：2015-09-11

  The invention provides novel compounds having the general formula (I): wherein R1, R2, R3, R4, R5, R6, X, Y, W and n are as described herein, compositions including the compounds and methods of using the compounds. These compounds useful for therapy and/or prophylaxis in a human, and in particular to Hepatitis B virus (HBV) inhibitors by targeting on HBV capsid for the treatment of HBV infection.
• Preparation of -(3S)-2,3-dimethylpentanal by reaction of (+)-tris[(2S)-1,2-dimethylbutoxy]methane (I) with carbon monoxide and hydrogen
  作者：Renzo Rossi、Piero Pino、Franco Piacenti、Luciano Lardicci、Goffredo Del Bino

  DOI：10.1021/jo01278a084

  日期：1967.3