2-(2-Cyclohexylethynyl)pyrazine | 1131447-29-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-(2-Cyclohexylethynyl)pyrazine
• 英文别名: 2-(2-cyclohexylethynyl)pyrazine
• CAS: 1131447-29-4
• 化学式: C₁₂H₁₄N₂
• 分子量: 186.257
• InChiKey: BISWWPAXQBUHKQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  环己基乙炔 、 2-甲硫基吡嗪 在 (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride 、 copper(l) iodide 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以68%的产率得到2-(2-Cyclohexylethynyl)pyrazine
  参考文献：
  名称：

  Microwave-assisted Sonogashira-type cross couplings of various heterocyclic methylthioethers

  摘要：

  A novel, microwave-assisted. palladium-catalyzed Sonogashira-type coupling of terminal alkynes with a variety of heteroaryl thiomethylethers is reported. The developed protocol allows for further utility and diversification of a number of chemically and biologically interesting scaffolds, (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.12.055

文献信息

• Microwave-assisted Sonogashira-type cross couplings of various heterocyclic methylthioethers
  作者：Brian C. Shook、Devraj Chakravarty、Paul F. Jackson

  DOI：10.1016/j.tetlet.2008.12.055

  日期：2009.3

  A novel, microwave-assisted. palladium-catalyzed Sonogashira-type coupling of terminal alkynes with a variety of heteroaryl thiomethylethers is reported. The developed protocol allows for further utility and diversification of a number of chemically and biologically interesting scaffolds, (C) 2008 Elsevier Ltd. All rights reserved.