1,3,5-Trichloro-6-hydroxy-1,3,5-triazinane-2,4-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪烷类
• 英文名称: 1,3,5-Trichloro-6-hydroxy-1,3,5-triazinane-2,4-dione
• 英文别名: 1,3,5-trichloro-6-hydroxy-1,3,5-triazinane-2,4-dione
• 化学式: C₃H₂Cl₃N₃O₃
• 分子量: 234.42
• InChiKey: KBMXBRUAGOMZHU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  64.1
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• 5 or 8-substituted imidazo[1, 5-a] pyridines as indoleamine and/or tryptophane 2, 3-dioxygenases
  申请人：BeiGene, Ltd.

  公开号：US10280163B2

  公开（公告）日：2019-05-07

  Disclosed herein are 5 or 8-substituted imidazo[1,5-a]pyridines and pharmaceutical compositions comprising at least one such 5 or 8-substituted imidazo[1,5-a]pyridines, processes for the preparation thereof, and the use thereof in therapy. Disclosed herein are certain 5 or 8-substituted imidazo[1,5-a]pyridines that can be useful for inhibiting indoleamine 2,3-dioxygenase and/or tryptophane 2,3-dioxygenase and for treating diseases or disorders mediated thereby.

  本文公开了 5 或 8-取代咪唑并[1,5-a]吡啶和包含至少一种此类 5 或 8-取代咪唑并[1,5-a]吡啶的药物组合物、其制备工艺及其在治疗中的应用。本文公开的某些 5 或 8-取代咪唑并[1,5-a]吡啶可用于抑制吲哚胺 2,3-二氧 化酶和/或色氨酸 2,3-二氧 化酶，并可用于治疗由其介导的疾病或紊乱。
• Compounds and compositions useful for treating disorders related to NTRK
  申请人：BLUEPRINT MEDICINES CORPORATION

  公开号：US10370379B2

  公开（公告）日：2019-08-06

  This disclosure relates to inhibitors of NTRK that are active against wild-type NTRK and its resistant mutants, such as compounds of Formula I:

  本公开涉及对野生型 NTRK 及其抗性突变体具有活性的 NTRK 抑制剂，如式 I 化合物：
• COMPOUNDS AND COMPOSITIONS USEFUL FOR TREATING DISORDERS RELATED TO NTRK
  申请人：BLUEPRINT MEDICINES CORPORATION

  公开号：US20170145018A1

  公开（公告）日：2017-05-25

  This invention relates to inhibitors of NTRK that are active against wild-type NTRK and its resistant mutants.
• NOVEL 5 OR 8-SUBSTITUTED IMIDAZO[1, 5-a] PYRIDINES AS INDOLEAMINE AND/OR TRYPTOPHANE 2, 3-DIOXYGENASES
  申请人：BeiGene, Ltd.

  公开号：US20180072716A1

  公开（公告）日：2018-03-15

  Disclosed herein are 5 or 8-substituted imidazo[1,5-a]pyridines and pharmaceutical compositions comprising at least one such 5 or 8-substituted imidazo[1,5-a]pyridines, processes for the preparation thereof, and the use thereof in therapy. Disclosed herein are certain 5 or 8-substituted imidazo[1,5-a]pyridines that can be useful for inhibiting indoleamine 2,3-dioxygenase and/or tryptophan 2,3-dioxygenase and for treating diseases or disorders mediated thereby.
• FTO Inhibitors
  申请人：National Institute of Biological Sciences, Beijing

  公开号：US20180118665A1

  公开（公告）日：2018-05-03

  The invention provides compounds that inhibit FTO (fat mass and obesity), including pharmaceutically acceptable salts, hydrides and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof, particularly obesity, with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.