N-(2-溴乙基)-N-甲基苯胺 | 51905-47-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: N-(2-溴乙基)-N-甲基苯胺
• 英文名称: N-Methyl,N-{(2-bromo)-1-ethyl}aniline
• 英文别名: N-Methyl-N-(2-bromoethyl)aniline；N-2-bromoethyl-N-methylaniline；Methyl-<2-brom-aethyl>-anilin；(2-bromo-ethyl)-methyl-phenyl-amine；N-(2-Brom-aethyl)-N-methyl-anilin；Methyl-(β-brom-aethyl)-anilin；N-(2-Bromoethyl)-N-methylaniline
• CAS: 51905-47-6
• 化学式: C₉H₁₂BrN
• 分子量: 214.105
• InChiKey: JSNHRRGVZQEAOB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2921420090
• 储存条件：
  | 2-8°C |

反应信息

• 作为反应物：
  描述：

  N-(2-溴乙基)-N-甲基苯胺 在 potassium carbonate 作用下， 以 丙酮 、 甲苯 为溶剂， 反应 22.0h， 生成
  参考文献：
  名称：

  Excited-State Interactions in Pyrrolidinofullerenes

  摘要：

  Two new pyrrolidinofullerenes, 1 and 2, have been synthesized, and their photophysical properties have been investigated. The pyrrolidinofullerene 1 has three phenyl groups attached to the 1, 2, and 5 positions of the pyrrolidine ring. The pyrrolidinofullerene 2, on the other hand, has a flexible attachment with an N-methylaniline end group and is the prototype of a fullerene-aniline dyed. Singlet and triplet excited-state properties of these two functionalized fullerene derivatives have been examined with picosecond and nanosecond laser flash photolysis. The singlet and triplet excited states of these fullerenes exhibit characteristic absorption bands in the vis-IR region of the spectrum. The functionalization of C-60 with pyrrolidine groups shift the excited-state absorption maxima to the blue. Three different quenchers, O-2, TEMPO, and ferrocene, are employed to investigate the reactivity of triplet excited states. The bimolecular quenching rate constants determined for these quenchers were in the range of 5.3 x 10(8) to 7.7 x 10(9) M-1 s(-1). The excited-state interactions of these functionalized fullerenes are compared to that of C-60.

  DOI：

  10.1021/jp972756z
• 作为产物：
  描述：

  N-(2-氯乙基)-N-甲基苯胺 在 氢溴酸 作用下， 生成 N-(2-溴乙基)-N-甲基苯胺
  参考文献：
  名称：

  v.Braun; Kirschbaum, Chemische Berichte, 1919, vol. 52, p. 1723

  摘要：

  DOI：

文献信息

• Intramolecular Oxidative C−H Coupling for Medium-Ring Synthesis
  作者：Didier G. Pintori、Michael F. Greaney

  DOI：10.1021/ja1090854

  日期：2011.2.9

  An oxidative C-H coupling is described for medium-ring synthesis.

  描述了用于中环合成的氧化 CH 偶联。
• [EN] SPIRO-ISOQUINOLINE-1,4'-PIPERIDINE COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN<br/>[FR] COMPOSÉS DE SPIRO-ISOQUINOLINE-1,4'-PIPÉRIDINE À ACTIVITÉ MULTIMODALE CONTRE LA DOULEUR
  申请人：ESTEVE LABOR DR

  公开号：WO2016078770A1

  公开（公告）日：2016-05-26

  The present invention relates to spiro-isoquinoline-1,4'-piperidine compounds having dual pharmacological activity towards both the sigma (σ) receptor and the μ-opiod receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.

  本发明涉及具有对σ受体和μ-阿片受体双重药理活性的螺环异喹啉-1,4'-哌啶化合物，以及制备这类化合物的方法，包括含有它们的药物组合物，以及它们在治疗中的应用，特别是用于疼痛治疗。
• Bicyclic cyclohexylamines and their use as nmda receptor antagonists
  申请人：——

  公开号：US20030236252A1

  公开（公告）日：2003-12-25

  Described are bicycle-substituted cyclohexylamines of Formula (I) and their pharmaceutically acceptable salts thereof. The compounds are antagonists of NMDA receptor channel complexes useful for treating cerebral vascular disorders such as, for example, cerebral ischemia, cardiac arrest, stroke, and Parkinson's specification. disease. The substituents are defined in the specification. 1

  描述了公式（I）的自行车替代环己胺及其药用盐。这些化合物是NMDA受体通道复合物的拮抗剂，可用于治疗脑血管疾病，例如脑缺血、心脏骤停、中风和帕金森病。这些取代基在规范中有定义。
• Herbicidal 5-aminoalkoxy-4-benzoyl-1,3-dimethyl-pyrazole derivatives
  申请人：Sankyo Company, Limited

  公开号：US04460597A1

  公开（公告）日：1984-07-17

  Pyrazole derivatives of formula (I): ##STR1## (R.sup.1 is methyl, halogen or nitro; n is 2 or 3; R.sup.2 is hydrogen, C.sub.1-4 alkyl, C.sub.3-4 alkenyl or aralkyl; R.sup.3 is C.sub.1-4 alkyl, C.sub.3-4 alkenyl or phenyl; A is C.sub.1-5 alkylene) are of use as herbicides.

  公式(I)的吡唑衍生物：##STR1##（其中，R.sup.1是甲基，卤素或硝基; n为2或3; R.sup.2是氢，C.sub.1-4烷基，C.sub.3-4烯基或苄基; R.sup.3是C.sub.1-4烷基，C.sub.3-4烯基或苯基; A为C.sub.1-5亚烷基）可用作除草剂。
• v.Braun, Chemische Berichte, 1937, vol. 70, p. 983
  作者：v.Braun

  DOI：——

  日期：——