N-(2-氯乙基)-N-甲基苯胺 | 1669-85-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: N-(2-氯乙基)-N-甲基苯胺
• 中文别名: 一缩二乙二醇一(2-乙基已基)醚；二甘醇(2-乙己基)醚；2-乙己基卡必醇；二甘醇一(2-乙己基)醚；二乙二醇单辛醚；一缩二乙二醇单(2-乙基已基)醚；2-{(2-[(2-乙基己基)氧基]乙氧基}乙醇；二甘醇单(2-乙己基)醚
• 英文名称: N-(2-chloroethyl)-N-methylaniline
• 英文别名: 2-(N-methyl-N-phenyl)-ethylaminochloride；N-methyl-N-β-chloroethylaniline；N-methyl-N-(2-chloroethyl)aniline；N-(2-chloro-ethyl)-N-methyl-aniline；N-(2-Chlor-aethyl)-N-methyl-anilin；Methyl-(β-chlor-aethyl)-anilin
• CAS: 1669-85-8
• 化学式: C₉H₁₂ClN
• mdl: MFCD01670150
• 分子量: 169.654
• InChiKey: KYTLVUBCXILIQO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2921420090

反应信息

• 作为反应物：
  描述：

  N-(2-氯乙基)-N-甲基苯胺 在 氢溴酸 作用下， 生成 N-(2-溴乙基)-N-甲基苯胺
  参考文献：
  名称：

  v.Braun; Kirschbaum, Chemische Berichte, 1919, vol. 52, p. 1723

  摘要：

  DOI：
• 作为产物：
  描述：

  N-(2-溴乙基)-N-甲基苯胺 在 盐酸 作用下， 生成 N-(2-氯乙基)-N-甲基苯胺
  参考文献：
  名称：

  v.Braun; Kirschbaum, Chemische Berichte, 1919, vol. 52, p. 1719

  摘要：

  DOI：

文献信息

• Anionic rearrangement of organosilyl groups from carbon to carbon in β-triorganosilylethylammonium ylides
  作者：Yoshiro Sato、Yasuchika Ban、Hideaki Shirai

  DOI：10.1016/s0022-328x(00)96125-4

  日期：1976.6

  β-triorganosilylethylammonium iodides with n-butyllithium in a HMPA/ether mixture at −15 to −20°C gave the corresponding α-triorganosilylalkylamines which were produced by 1,4-anionic rearrangement of organosilyl groups from carbon to carbon in β-triorganosilylethylammonium ylides. Small amounts of the Hofmann elimination products, triorganovinylsilane and N,N-dialkyl-2-trimethylsilylethylamines, were also detected

  β-三有机甲硅烷基乙基碘化铵与正丁基锂在HMPA /醚混合物中在-15至-20°C下反应，得到相应的α-三有机甲硅烷基烷基胺，它是通过将有机甲硅烷基中的1,4-阴离子从碳到碳的碳原子重排成碳而制得的三有机甲硅烷基乙基铵盐。还检测到少量的霍夫曼消除产物，三有机乙烯基硅烷和N，N-二烷基-2-三甲基甲硅烷基乙基胺。
• ROS-Activated Compounds as Selective Anti-Cancer Therapeutics
  申请人：UNIVERSITY OF CINCINNATI

  公开号：US20130230542A1

  公开（公告）日：2013-09-05

  Provided are compounds according to the following Formula I: The Formula I compounds are activated in the presence of reactive oxygen species (ROS) and are therefore selective anti-cancer therapeutics for cancers associated with elevated ROS. Also provided are methods and pharmaceutical compositions for treating cancers associated with increased ROS.

  根据以下的公式I提供了化合物：公式I化合物在存在活性氧气体（ROS）的情况下被激活，因此对于与增加ROS相关的癌症是选择性的抗癌治疗药物。还提供了用于治疗与增加ROS相关的癌症的方法和药物组合物。
• Ru‐Catalyzed Switchable <i>N</i> ‐Hydroxyethylation and <i>N</i> ‐Acetonylation with Crude Glycerol
  作者：Zhuo Xin、Le Jia、Yuxing Huang、Chen‐Xia Du、Yuehui Li

  DOI：10.1002/cssc.201903151

  日期：2020.4.21

  Highly efficient Ru-catalyzed selective C-C or C-O bond cleavage of polyols (e.g., crude glycerol) for N-hydroxyethylation or N-acetonylation of amines was achieved through the hydrogen-borrowing approach. A variety of amines were transformed to the desired amino alcohols/ketones in moderate-to-excellent yields, opening up new avenues for generation of oxygenated pharmaceuticals and fine chemicals

  通过氢借入方法实现了多元醇（例如粗甘油）对胺的N-羟乙基化或N-乙酰化的高效Ru催化选择性CC或CO键裂解。各种胺以中等至优异的产率转化为所需的氨基醇/酮，为从可再生原料生产含氧药物和精细化学品开辟了新途径。使用含有双膦/噻吩基甲胺配体的新型氧化还原活性催化剂可使该氢借用体系在碱性和酸性条件下选择性地操作。
• 一种4-(N-甲基-N-磺基乙基)氨基苯甲醛钠 盐的合成方法
  申请人：天长市天佳化工科技有限公司

  公开号：CN105017090B

  公开（公告）日：2017-07-25

  本发明公开了一种4‑(N‑甲基‑N‑磺基乙基)氨基苯甲醛钠盐的合成方法，包括如下步骤：将N‑甲基‑N‑羟乙基苯胺和含氯氧化物加入有机溶剂中进行取代反应生成N‑甲基‑N‑氯乙基苯胺；将N‑甲基‑N‑氯乙基苯胺、二取代甲酰胺与三氯氧磷进行维尔斯迈尔‑哈克反应生成N‑甲基‑N‑氯乙基‑4‑氨基苯甲醛；将N‑甲基‑N‑氯乙基‑4‑氨基苯甲醛与磺化剂在碱性溶液中进行磺化反应生成4‑(N‑甲基‑N‑磺基乙基)氨基苯甲醛钠盐。本发明的原料廉价易得，工艺简单，适合大规模工业化生产。
• Modified Lapidus Procedure for the Treatment of Hypermobile Hallux Valgus
  作者：Paul A. Bednarz、Arthur Manoli

  DOI：10.1177/107110070002101004

  日期：2000.10

  The intermediate outcome of patients who underwent a modified Lapidus procedure for the treatment of hallux valgus secondary to a hypermobile first ray was evaluated with an outcome tool to determine if their pain and functional status were improved. We evaluated 31 feet in 26 patients who underwent a modified Lapidus procedure. All working patients (100%) returned to full-time work. Six patients were retired and one was unemployed prior to surgery. There was an average of eight months until sports or unlimited activities were performed, and an average 16 weeks until conventional shoes could be worn. All patients but one (96%) were satisfied with the surgery and knowing their results would have the surgery again. Postoperative pain relief satisfaction was totally satisfied in 19 patients, satisfied with reservations in six patients, and not satisfied in one patient. Postoperative appearance satisfaction was totally satisfied in 21 patients and satisfied with reservations in five patients. Postoperative joint motion was no noticeable stiffness in 22 patients, noticeable stiffness but not bothersome in three patients, and stiffness that impairs activity in one patient (two feet). In the radiographic measurements, there was an average improvement of 10 degrees in the hallux valgus angle, 10 degrees in the intermetatarsal angle, two degrees in the lateral metatarsal-floor angle and two grades in the sesamoid position. Complications experienced were five recurrent deformities, two metatarsalgias, and one deep vein thrombosis. One of the five recurrences became symptomatic and required a revision.

  通过使用一个结果工具来评估经过改良的Lapidus手术治疗由于第一跖骨过度活动引起的拇外翻症患者的中间结果，以确定他们的疼痛和功能状态是否得到改善。我们评估了26名患者中的31只脚接受了改良的Lapidus手术。所有工作患者（100％）都恢复到了全职工作。术前有6名患者退休，1名失业。平均需要8个月才能进行运动或无限制活动，平均16周才能穿上传统鞋子。除一名患者外（96％），所有患者都对手术结果满意，并且知道他们的结果会再次接受手术。术后疼痛缓解满意度在19名患者中完全满意，在6名患者中满意但有保留，在一名患者中不满意。术后外观满意度在21名患者中完全满意，在5名患者中满意但有保留。术后关节活动范围在22名患者中没有明显的僵硬，3名患者中有明显的僵硬但不影响活动，1名患者（2只脚）有影响活动的僵硬。在放射学测量中，拇外翻角度平均改善了10度，跖骨间角度平均改善了10度，侧跖骨-地板角度平均改善了2度，而骶骨骨骼位置平均提高了2级。经历的并发症包括5例复发畸形，2例跖部疼痛和1例深静脉血栓形成。其中5个复发病例中的一个出现症状，需要进行修复手术。