4-[1-(Tributylstannyl)-2-(trimethylsilyl)ethenyl]benzoic acid ethyl ester

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[1-(Tributylstannyl)-2-(trimethylsilyl)ethenyl]benzoic acid ethyl ester
• 化学式: C26H46O2SiSn
• 分子量: 537.4
• InChiKey: YSYIHDXLKZUSOW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.51
• 重原子数：
  30
• 可旋转键数：
  15
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-[1-(Tributylstannyl)-2-(trimethylsilyl)ethenyl]benzoic acid ethyl ester 在 tris-(dibenzylideneacetone)dipalladium(0) 、 copper(l) iodide 、 三苯胂 、 溶剂黄146 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 40.0h， 生成 4-[1-(4-methoxy-phenyl)-vinyl]-benzoic acid ethyl ester
  参考文献：
  名称：

  Synthesis of 1,1-diarylethylenes from an α-stannyl β-silylstyrene

  摘要：

  The synthesis of a family of 1,1-diaryiethylenes from an alpha-stannyl beta-silylstyrene through a combination of a Stille coupling and a protodesilylation reaction is described. This approach avoids the problematic cine-substitution, which is a well documented side reaction during the palladium-assisted elaboration of a-substituted vinylstannanes to 1,1-disubstituted ethylenes. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2003.12.106

文献信息

• Retinoic acid receptor antagonists as promoters of angiogenesis
  申请人：——

  公开号：US20020120006A1

  公开（公告）日：2002-08-29

  Methods and compositions for treating various disorders by administering a therapeutically effective amount of a retinoic acid receptor antagonist alone or in combination or in conjunction with other therapeutic agents to promote angiogenesis are provided. Also provided are methods for obtaining additional retinoic acid receptor antagonists for use as therapeutic agents to promote angiogenesis.

  提供了通过单独或与其他治疗剂联合或结合使用维甲酸受体拮抗剂的治疗方法和组合物，以治疗各种疾病，促进血管生成。还提供了获取额外的维甲酸受体拮抗剂用作治疗剂以促进血管生成的方法。
• Synthesis of 1,1-diarylethylenes from an α-stannyl β-silylstyrene
  作者：Makonen Belema、Van N. Nguyen、F. Christopher Zusi

  DOI：10.1016/j.tetlet.2003.12.106

  日期：2004.2

  The synthesis of a family of 1,1-diaryiethylenes from an alpha-stannyl beta-silylstyrene through a combination of a Stille coupling and a protodesilylation reaction is described. This approach avoids the problematic cine-substitution, which is a well documented side reaction during the palladium-assisted elaboration of a-substituted vinylstannanes to 1,1-disubstituted ethylenes. (C) 2004 Elsevier Ltd. All rights reserved.