N-(2-甲基-1-氧代烯丙基)甲基丙烯酰胺 | 7370-82-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: N-(2-甲基-1-氧代烯丙基)甲基丙烯酰胺
• 英文名称: Dimethacrylamide
• 英文别名: N-(2-methyl-1-oxoallyl)methacrylamide；(meth)acrylic acid, (meth)acrylamide；Bis-N,N-methacryloylimid；Bis-methacryloyl-amin；Bis-(methacryl)-amid；Dimethacrylamid；2-methyl-N-(2-methylprop-2-enoyl)prop-2-enamide
• CAS: 7370-82-3
• 化学式: C₈H₁₁NO₂
• 分子量: 153.181
• InChiKey: ABGYXXMZWPKYAU-UHFFFAOYSA-N

物化性质

• 沸点：
  245.8±7.0 °C(Predicted)
• 密度：
  0.998±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  甲基丙烯酰胺 、 甲基丙烯酰氯 生成 N-(2-甲基-1-氧代烯丙基)甲基丙烯酰胺
  参考文献：
  名称：

  Rudkovskaya,G.D.; Sokolova,T.A., Journal of Organic Chemistry USSR (English Translation), 1966, vol. 2, p. 1212 - 1214

  摘要：

  DOI：

文献信息

• Solid phase method for synthesis peptide-spacer-lipid conjugates, conjugates synthesized thereby and targeted liposomes containing the same
  申请人：DEVELOPMENT CENTER FOR BIOTECHNOLOGY

  公开号：US20030229017A1

  公开（公告）日：2003-12-11

  A solid phase synthesis method for preparing peptide-spacer-lipid conjugates, the peptide-spacer-lipid conjugates synthesized by the method, and liposomes containing the peptide-spacer-lipid conjugates. The present invention provides a convenient solid phase synthesis method for preparing peptide-spacer-lipid conjugates and provides various linkage groups (such as amide group) for conjugating peptide, spacer and lipid, wherein the spacer may comprise PEG. Several advantages can be achieved, such as the synthetic procedure can be simplified, the synthesis process can be set to automation, the purification is easier in each reaction step, and the product losses can be reduced to minimal during synthesis. The present synthesis method is suitable for preparing a wide range of peptide-spacer-lipid conjugates, provides a peptide-spacer-lipid conjugate prepared by the solid phase synthesis method of the present invention, which can be incorporated into a liposome as the targeting moiety for liposomal drug delivery to specific cells, and provides a targeting liposome containing the present peptide-spacer-lipid conjugate.

  一种用于制备肽-间隔子-脂质共轭物的固相合成方法，所述方法合成的肽-间隔子-脂质共轭物，以及含有肽-间隔子-脂质共轭物的脂质体。本发明提供了一种便利的固相合成方法，用于制备肽-间隔子-脂质共轭物，并提供了各种连接基团（如酰胺基团）用于连接肽、间隔子和脂质，其中间隔子可以包括PEG。可以实现几项优点，例如合成过程可以简化，合成过程可以设定为自动化，每个反应步骤中的纯化更容易，并且在合成过程中产品损失可以降至最低。本合成方法适用于制备各种肽-间隔子-脂质共轭物，提供了一种由本发明的固相合成方法制备的肽-间隔子-脂质共轭物，可作为靶向单元被纳入脂质体，用于将脂质体药物传递到特定细胞，并提供了含有本肽-间隔子-脂质共轭物的靶向脂质体。
• Process for preparing vinyl substituted beta-diketones
  申请人：Southard E. Glen

  公开号：US20060069288A1

  公开（公告）日：2006-03-30

  A process for preparing vinyl substituted beta-diketones includes reacting a halogen-containing beta-diketone with an olefin in a reaction zone under Heck coupling reaction conditions in the presence of a catalyst, a base, and an organic phosphine to provide a vinyl substituted beta-diketone product.

  制备乙烯基取代的β-二酮的方法包括在反应区域中，在存在催化剂、碱和有机膦的条件下，将含卤素的β-二酮与烯烃进行 Heck 偶联反应，从而得到乙烯基取代的β-二酮产物。
• Polymeric boronic acid derivatives as lipase inhibitors
  申请人：Huval Cori Chad

  公开号：US20060134062A1

  公开（公告）日：2006-06-22

  Human obesity is a health problem affecting a significant proportion of the American population. Numerous methods of treating obesity have been developed, but all have serious drawbacks. The present invention discloses a novel class of polymers with either a sulfur atom or an electron withdrawing group between a polymer backbone and a pendant aryl boronic acid group. Polymers having such an electron withdrawing group have been found to be particularly effective in inhibiting lipase in vitro and in vivo. Methods of treating obesity and reducing absorption of fat are also disclosed.

  人类肥胖是影响美国人口相当大比例的健康问题。已经开发了许多治疗肥胖的方法，但都存在严重缺陷。本发明揭示了一种新型聚合物类别，其在聚合物主链和挂链芳基硼酸基团之间具有硫原子或电子吸引基团。发现具有这种电子吸引基团的聚合物在体外和体内抑制脂肪酶特别有效。还公开了治疗肥胖和减少脂肪吸收��方法。
• RADIATION ENHANCED MACROMOLECULAR DELIVERY OF THERAPEUTIC AGENTS FOR CHEMOTHERAPY
  申请人：UNIVERSITY OF UTAH RESEARCH FOUNDATION

  公开号：US20160166693A1

  公开（公告）日：2016-06-16

  Described herein are anti-cancer compounds composed of a macromolecule comprising (1) at least one anti-cancer agent directly or indirectly bonded to the macromolecule and (2) at least one high Z element directly or indirectly bonded to the macromolecule that is capable of producing Auger electrons upon exposure to X-ray energy. When the compounds are exposed to low energy X-ray (e.g., kilo electron volts KeV) Auger electrons are produced by the high Z elements present in the compound. Because lower energy is required when compared to typical radiotherapy, which uses therapeutic X-ray energy in the million electron volt range (MeV), the subject experiences lower collateral damage when compared to radiation therapy. Additionally, the presence of the anti-cancer agent provides a second mechanism for killing cancer cells. Methods for making and using the anti-cancer compounds are also described herein.

  本文描述了一种抗癌化合物，由包括（1）至少一种直接或间接与大分子结合的抗癌药物和（2）至少一种直接或间接与大分子结合的高Z元素组成，该高Z元素在暴露于X射线能量时能够产生奥古尔电子。当这些化合物暴露于低能量X射线（例如，千电子伏特KeV）时，化合物中存在的高Z元素会产生奥古尔电子。与使用百万电子伏特范围内的治疗性X射线能量（MeV）的典型放射疗法相比，所需的能量更低，因此受试者在与放射疗法相比时经历较低的附带损伤。此外，抗癌药物的存在提供了杀死癌细胞的第二机制。本文还描述了制备和使用抗癌化合物的方法。
• [EN] COLORANT MULTIMER, COLORED CURABLE COMPOSITION, COLOR FILTER AND METHOD FOR PRODUCING THE SAME, AND SOLID-STATE IMAGE SENSOR, IMAGE DISPLAY DEVICE, LIQUID CRYSTAL DISPLAY DEVICE AND ORGANIC EL DISPLAY WITH THE COLOR FILTER<br/>[FR] MULTIMÈRE COLORANT, COMPOSITION DURCISSABLE COLORÉE, FILTRE COLORÉ ET PROCÉDÉ DE FABRICATION DE CEUX-CI, ET DÉTECTEUR D'IMAGES À L'ÉTAT SOLIDE, DISPOSITIF D'AFFICHAGE D'IMAGES, DISPOSITIF D'AFFICHAGE À CRISTAUX LIQUIDES ET DISPOSITIF D'AFFICHAGE ÉLEC
  申请人：FUJIFILM CORP

  公开号：WO2011040628A1

  公开（公告）日：2011-04-07

  A colorant multimer includes, as a partial structure of a colorant moiety, a dipyrromethene metal complex compound or tautomer thereof obtained from: (i) a dipyrromethene compound represented by the following Formula (M); and (ii) a metal or a metal compound: wherein in Formula (M), R4, R5, R6, R7, R8, R9, and R10 each independently represent a hydrogen atom or a monovalent substituent.

  一种着色剂多聚体包括作为着色剂部分结构的二吡咯甲烷金属配合物化合物或其互变异构体，所述化合物由以下公式（M）表示的二吡咯甲烷化合物和金属或金属化合物得到：其中在公式（M）中，R4、R5、R6、R7、R8、R9和R10分别独立地表示氢原子或一价取代基。