(2-Butoxy-phenyl)-acetic acid | 143895-99-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (2-Butoxy-phenyl)-acetic acid
• 英文别名: (2-Butoxyphenyl)acetic acid；2-(2-butoxyphenyl)acetic acid
• CAS: 143895-99-2
• 化学式: C₁₂H₁₆O₃
• mdl: MFCD06653493
• 分子量: 208.257
• InChiKey: GDVFKEUCAFZRKK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (2-Butoxy-phenyl)-acetic acid 在 氯化亚砜 作用下， 生成 2-(2-butoxyphenyl)acetyl chloride
  参考文献：
  名称：

  取代的 4-氨基-1,3,5-三芳基-1H-吡咯-2(5H)-酮的合成

  摘要：

   抽象的 通过用芳基乙酰氯酰化 α-芳基氨基腈并随后在氢氧化钾存在下进行分子内环化，合成了 4-氨基-1,3,5-三芳基-1H-吡咯-2(5H)-酮的新衍生物。类似地，1-烯丙基-4-氨基-3,5-二苯基-1,5-二氢-2H-吡咯-2-酮由2-(烯丙基氨基)-2-苯基乙腈与β-乙烯键形成。 2-苯基-1-(2-苯乙酰基)吡咯烷-2-甲腈是通过2-(3-氯丙氨基)-2-苯基乙腈与苯乙酰氯的酰化和随后的分子内环化合成的。在氢氧化钾存在下，N-(3-氯丙基)-N-(氰基(苯基)甲基-2-苯基乙酰胺发生分子内环化时，反应进行时同时闭合第二个环并形成双环产品 – 1-氨基-2,7a-二苯基-5,6,7,7a-四氢-3H-吡咯嗪-3-酮。

  DOI：

  10.1134/s1070363224050037

文献信息

• [EN] INSECTICIDAL DIAZOLE AND TRIAZOLE DERIVATIVES<br/>[FR] DERIVES DE DIAZOLE ET DE TRIAZOLE INSECTICIDES
  申请人：FMC CORP

  公开号：WO2005108374A1

  公开（公告）日：2005-11-17

  It has now been found that certain novel diazole and triazole derivatives have provided unexpected insecticidal activity. These compounds are represented by formula (I). Preferred are those compounds of formula (I) where M and Q are carbon; R is methyl; R1 and R2 taken together are -CH=CHCH=CH-, -C(Cl)=CHCH=CH-, -C(F)=CHCH=CH-, or -C(CH3)=CHCH=CH-; X is straight or branched chain alkylenyl; Y is phenyl; and R4 is one or more hydrogen, halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, cyano, amino, or -(O)t-(CH2)v-Z-R6, where Z is -C(R7)=C(R8)-, -C≡C-, or -C(R7)=NO-; and, R6, R7 and R8 are indepdently hydrogen, halogen, or alky. In addition, compositions comprising an insecticidally effective amount of at least one compound of formula (I), and optionally, an effective amount of at least one of a second compound, with at least one insecticidally compatible carrier are also disclosed; along with methods of controlling insects comprising applying said compositions to the locus of crops where insects are present or are expected to be present.

  已经发现了某些新型二唑和三唑衍生物具有意想不到的杀虫活性。这些化合物由式(I)表示。首选的是式(I)中M和Q为碳；R为甲基；R1和R2一起取-CH=CHCH=CH-, -C(Cl)=CHCH=CH-, -C(F)=CHCH=CH-或-C(CH3)=CHCH=CH-；X为直链或支链烷基；Y为苯基；R4为一个或多个氢、卤素、烷基、卤代烷基、烷氧基、卤代烷氧基、氰基、氨基或-(O)t-(CH2)v-Z-R6，其中Z为-C(R7)=C(R8)-，-C≡C-或-C(R7)=NO-；而R6、R7和R8独立地为氢、卤素或烷基。此外，还公开了包含至少一种式(I)化合物的杀虫有效量和可选地至少一种第二化合物的有效量，以及至少一种杀虫载体的组合物；以及涉及将这些组合物施用于存在或预计存在昆虫的作物生长地点以控制昆虫的方法。
• [EN] USE OF DERIVATIVES OF 2, 4-DIHYDRO-[1,2,4]TRIAZOLE-3-THIONE AS INHIBITORS O FTEH ENZYME MYELOPEROXIDASE (MPO)<br/>[FR] UTILISATION DE DERIVES DE 2, 4-DIHYDRO-[1,2,4]TRIAZOLE-3-THIONES COMME INHIBITEURS DE L'ENZYME MYELOPEROXYDASE (MPO)
  申请人：ASTRAZENECA AB

  公开号：WO2004096781A1

  公开（公告）日：2004-11-11

  There is disclosed the use of a compound of formula (I) wherein X, Y, W and Q are as defined in the specification, and pharmaceutically acceptable salts thereof, in the manufacture of a medicament, for the treatment or prophylaxis of diseases or conditions in which inhibition of the enzyme myeloperoxidase (MPO) is beneficial. Certain novel compounds of formula (I) and pharmaceutically acceptable salts thereof are disclosed, together with processes for their preparation. The compounds of formulae (I) are MPO inhibitors and are thereby particularly useful in the treatment or prophylaxis of neuroinflammatory disorders.

  揭示了使用公式(I)中X、Y、W和Q如规范中定义的化合物及其药用盐，在制造药物中用于治疗或预防对髓过氧化物酶（MPO）抑制有益的疾病或症状。公开了某些公式(I)的新化合物及其药用盐，以及它们的制备方法。公式(I)的化合物是MPO抑制剂，因此在治疗或预防神经炎症性疾病中特别有用。
• Use of derivatives of 2, 4-dihydro-[1,2,4] triazole-3-thione as inhibitors of the enzyme myeloperoxidase (mpo)
  申请人：Svensson Mats

  公开号：US20070093483A1

  公开（公告）日：2007-04-26

  There is disclosed the use of a compound of formula (I) wherein X, Y, W and Q are as defined in the specification, and pharmaceutically acceptable salts thereof, in the manufacture of a medicament, for the treatment or prophylaxis of diseases or conditions in which inhibition of the enzyme myeloperoxidase (MPO) is beneficial. Certain novel compounds of formula (I) and pharmaceutically acceptable salts thereof are disclosed, together with processes for their preparation. The compounds of formulae (I) are MPO inhibitors and are thereby particularly useful in the treatment or prophylaxis of neuroinflammatory disorders.

  本发明揭示了使用化合物(I)的使用，其中X、Y、W和Q如规范中所定义，以及其药学上可接受的盐，在制造药物方面，用于治疗或预防抑制髓过氧化物酶（MPO）酶有益的疾病或状况。揭示了某些新型化合物(I)及其药学上可接受的盐，以及其制备方法。化合物(I)的MPO抑制剂，因此特别适用于治疗或预防神经炎症性疾病。
• PHOSPHONATE COMPOUNDS HAVING IMMUNO-MODULATORY ACTIVITY
  申请人：Cannizzaro Carina

  公开号：US20090227543A1

  公开（公告）日：2009-09-10

  The invention is related to phosphonate substituted compounds having immuno-modulatory activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

  本发明涉及磷酸酯取代化合物，具有免疫调节活性，含有这种化合物的组合物，以及包括这种化合物的给药的治疗方法，还涉及用于制备这种化合物的有用过程和中间体。
• ANTI-INFLAMMATORY PHOSPHONATE COMPOUNDS
  申请人：Cannizzaro Carina

  公开号：US20090247488A1

  公开（公告）日：2009-10-01

  The invention is related to phosphorus substituted anti-inflammatory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

  本发明涉及磷取代的抗炎化合物、含有这种化合物的组合物、包括给药这种化合物的治疗方法，以及用于制备这种化合物的有用过程和中间体。