ethyl (2R,3R)-3-carbamoyloxirane-2-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 环氧化物
• 英文名称: ethyl (2R,3R)-3-carbamoyloxirane-2-carboxylate
• 化学式: C₆H₉NO₄
• 分子量: 159.14
• InChiKey: ZWOFWVGNYHOVDW-QWWZWVQMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  81.9
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Novel Cysteine Protease Inhibitors and Uses Thereof
  申请人：The Trustees of Columbia University in the city of New York

  公开号：US20150045393A1

  公开（公告）日：2015-02-12

  The invention provides for novel cysteine protease inhibitors and compositions comprising novel cysteine protease derivatives. The invention further provides for methods for treatment of neurodegenerative diseases comprising administration novel cysteine protease inhibitors or compositions comprising novel cysteine protease inhibitors. In some embodiments, the cysteine protease inhibitors are calpain inhibitors.

  该发明提供了新型半胱氨酸蛋白酶抑制剂和包含新型半胱氨酸蛋白酶衍生物的组合物。该发明还提供了治疗神经退行性疾病的方法，包括给予新型半胱氨酸蛋白酶抑制剂或包含新型半胱氨酸蛋白酶抑制剂的组合物。在某些实施例中，半胱氨酸蛋白酶抑制剂为钙蛋白酶抑制剂。
• Cysteine protease inhibitors and uses thereof
  申请人：The Trustees of Columbia University in the City of New York

  公开号：US10647709B2

  公开（公告）日：2020-05-12

  The invention provides for novel cysteine protease inhibitors and compositions comprising novel cysteine protease derivatives. The invention further provides for methods for treatment of neurodegenerative diseases comprising administration novel cysteine protease inhibitors or compositions comprising novel cysteine protease inhibitors. In some embodiments, the cysteine protease inhibitors are calpain inhibitors.

  本发明提供了新型半胱氨酸蛋白酶抑制剂和包含新型半胱氨酸蛋白酶衍生物的组合物。本发明进一步提供了治疗神经退行性疾病的方法，包括施用新型半胱氨酸蛋白酶抑制剂或包含新型半胱氨酸蛋白酶抑制剂的组合物。在某些实施方案中，半胱氨酸蛋白酶抑制剂是钙蛋白酶抑制剂。
• NOVEL CYSTEINE PROTEASE INHIBITORS AND USES THEREOF
  申请人：The Trustees of Colubmia University in the City of New York

  公开号：US20170008884A1

  公开（公告）日：2017-01-12

  The invention provides for novel cysteine protease inhibitors and compositions comprising novel cysteine protease derivatives. The invention further provides for methods for treatment of neurodegenerative diseases comprising administration novel cysteine protease inhibitors or compositions comprising novel cysteine protease inhibitors. In some embodiments, the cysteine protease inhibitors are calpain inhibitors.
• US9403843B2
  申请人：——

  公开号：US9403843B2

  公开（公告）日：2016-08-02