1,1-dimethylethyl-4-{1[[3-fluoro-4-(4-morpholinyl)phenyl](1-piperidinylcarbonyl)amino]methyl}-1-piperidinecarboxylate | 856889-58-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 1,1-dimethylethyl-4-{1[[3-fluoro-4-(4-morpholinyl)phenyl](1-piperidinylcarbonyl)amino]methyl}-1-piperidinecarboxylate
• 英文别名: tert-butyl 4-[[3-fluoro-4-morpholin-4-yl-N-(piperidine-1-carbonyl)anilino]methyl]piperidine-1-carboxylate
• CAS: 856889-58-2
• 化学式: C₂₇H₄₁FN₄O₄
• 分子量: 504.645
• InChiKey: DJLAKJZTJOFXFC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  36
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  65.6
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  哌啶 、 1,1-dimethylethyl 4-({[3-fluoro-4-(4-morpholinyl)phenyl]amino}methyl)-1-piperidinecarboxylate 、 三光气 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 以100%的产率得到1,1-dimethylethyl-4-{1[[3-fluoro-4-(4-morpholinyl)phenyl](1-piperidinylcarbonyl)amino]methyl}-1-piperidinecarboxylate
  参考文献：
  名称：

  [EN] PIPERIDINE DERIVATIVES AND THEIR USE AS GLYCINE TRANSPORTER INHIBITORS
  [FR] COMPOSES

  摘要：

  公开号：

  WO2005058885A3

文献信息

• [EN] Substituted urea-octatydroindols as antagonists of melanin concentrating hormone receptor 1 (MCH1R)<br/>[FR] UREE-OCTAHYDROINDOLES SUBSTITUES UTILISES EN TANT QU'ANTAGONISTES DU RECEPTEUR 1 DE L'HORMONE CONCENTRANT LA MELANINE (MCH1R)
  申请人：BIOVITRUM AB

  公开号：WO2005051381A1

  公开（公告）日：2005-06-09

  The invention relates to compounds of the general formula (I) wherein R0, R1, R2, R3, R4, R5, R6, R7, R8, R9, Ar, and X are as defined in the description, or a pharmaceutically acceptable salt, hydrates, geometrical isomers, racemates, tautomers, optical isomers, N-oxides and prodrug forms thereof. The compounds may be used for the treatment or prophylaxis of disorders related to the MCH1R receptor and for modulation of appetite. The invention also relates to such use as well as to pharmaceutical formulations comprising a compound of formula (I).

  该发明涉及通式（I）的化合物，其中R0、R1、R2、R3、R4、R5、R6、R7、R8、R9、Ar和X如描述中所定义，或其药学上可接受的盐、水合物、几何异构体、消旋体、互变异构体、光学异构体、N-氧化物及其前药形式。这些化合物可用于治疗或预防与MCH1R受体相关的疾病，并用于调节食欲。该发明还涉及该用途以及包含通式（I）化合物的药物配方。
• [EN] COMPOUNDS<br/>[FR] COMPOSES
  申请人：GLAXO GROUP LTD

  公开号：WO2005058885A2

  公开（公告）日：2005-06-30

  The invention provides a compound of formula (I) or a salt or solvate thereof: (I) wherein R1 to R8, X and Ar are as defined in the specification, and uses of such compounds. The compounds inhibit GlyT1 transporters and are useful in the treatment of certain neurological and neuropsychiatric disorders, including schizophrenia.