diethyl 3,5-bis(4-bromophenyl)-4-nitropyrrolidine-2,2-dicarboxylate | 1616482-60-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: diethyl 3,5-bis(4-bromophenyl)-4-nitropyrrolidine-2,2-dicarboxylate
• 英文别名: diethyl (3R,4R,5R)-3,5-bis(4-bromophenyl)-4-nitropyrrolidine-2,2-dicarboxylate
• CAS: 1616482-60-0
• 化学式: C₂₂H₂₂Br₂N₂O₆
• 分子量: 570.234
• InChiKey: LCELCVBVXRVZGJ-GUDVDZBRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  32
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  110
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  氨基丙二酸二乙酯 、 反-4-溴-β-硝基苯乙烯 、 对溴苯甲醛 在 (S)-3,3'-双(9-蒽基)-1,1'-联萘-2,2'-二基磷酸氢酯 作用下， 以 氯仿 为溶剂， 以70%的产率得到
  参考文献：
  名称：

  Chiral phosphoric acid catalyzed 1,3-dipolar cycloadditions of aldehydes, diethyl α-aminomalonate, and nitroalkenes

  摘要：

  A one-pot three component 1,3-dipolar cycloaddition reaction of an aldehyde, alpha-aminomalonate, and nitroalkene has been developed through binaphthol derived chiral phosphoric acids. This reaction represents one of the most enantioselective catalytic approaches to access structurally diverse pyrrolidine derivatives. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2014.04.006

文献信息

• Chiral phosphoric acid catalyzed 1,3-dipolar cycloadditions of aldehydes, diethyl α-aminomalonate, and nitroalkenes
  作者：Wenqiang Luo、Yongjun Lin、Dengshan Yang、Long He

  DOI：10.1016/j.tetasy.2014.04.006

  日期：2014.5

  A one-pot three component 1,3-dipolar cycloaddition reaction of an aldehyde, alpha-aminomalonate, and nitroalkene has been developed through binaphthol derived chiral phosphoric acids. This reaction represents one of the most enantioselective catalytic approaches to access structurally diverse pyrrolidine derivatives. (C) 2014 Elsevier Ltd. All rights reserved.