2,2-Dimethyl-3-(aethoxycarbonyl)-cyclobutanessigsaeure | 13977-09-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2,2-Dimethyl-3-(aethoxycarbonyl)-cyclobutanessigsaeure
• 英文别名: (3-ethoxycarbonyl-2,2-dimethyl-cyclobutyl)-acetic acid；(3-Aethoxycarbonyl-2,2-dimethyl-cyclobutyl)-essigsaeure；2-(3-Ethoxycarbonyl-2,2-dimethylcyclobutyl)acetic acid
• CAS: 13977-09-8
• 化学式: C₁₁H₁₈O₄
• 分子量: 214.262
• InChiKey: XJEJGVHVQJKIMI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,2-Dimethyl-3-(aethoxycarbonyl)-cyclobutanessigsaeure 在 氯化亚砜 、 苯 作用下， 生成 3-chlorocarbonylmethyl-2,2-dimethyl-cyclobutanecarboxylic acid ethyl ester
  参考文献：
  名称：

  Acupressure and ondansetron for postoperative nausea and vomiting after laparoscopic cholecystectomy

  摘要：

  Purpose: To compare the efficacy of acupressure wrist bands and ondansetron for the prevention of postoperative nausea and vomiting (PONV).Methods: One hundred and fifty ASA I-II, patients undergoing elective laparoscopic cholecystectomy were included in a randomized, prospective, double-blind and placebo-controlled study. Patients were divided into three groups of 50. Group I was the control; Group 11 received ondansetron 4 mg iv just prior to induction of anesthesia; in Group III acupressure wristbands were applied at the P6 points. Acupressure wrist bands Were placed inappropriately in Groups I and 11, The acupressure wrist bands were applied 30 min prior to induction of anesthesia and removed six hours following surgery. Anesthesia was standardized. PONV were evaluated separately as none, mild, moderate or severe within six hours of patients' arrival in the postanesthesia care unit and then at 24 hr after surgery by a blinded observer If patients vomited more than once, they were given 4 mg ondansetron iv as the rescue antiemetic.Results were analyzed by Z test. A P value of < 0.05 was taken as significant. Results: The incidence of PONV and the requirement of rescue medication were significantly lower in both the acupressure and ondansetron groups during the first six hours.Conclusion: Acupressure at P6 causes a significant reduction in the incidence of PONV and the requirement for rescue medication in the first six hours following laparoscopic cholecystectomy, similar to that of ondansetron 4 mg iv.

  DOI：

  10.1007/bf03017380
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 氢氧化钾 作用下， 生成 2,2-Dimethyl-3-(aethoxycarbonyl)-cyclobutanessigsaeure
  参考文献：
  名称：

  Acupressure and ondansetron for postoperative nausea and vomiting after laparoscopic cholecystectomy

  摘要：

  Purpose: To compare the efficacy of acupressure wrist bands and ondansetron for the prevention of postoperative nausea and vomiting (PONV).Methods: One hundred and fifty ASA I-II, patients undergoing elective laparoscopic cholecystectomy were included in a randomized, prospective, double-blind and placebo-controlled study. Patients were divided into three groups of 50. Group I was the control; Group 11 received ondansetron 4 mg iv just prior to induction of anesthesia; in Group III acupressure wristbands were applied at the P6 points. Acupressure wrist bands Were placed inappropriately in Groups I and 11, The acupressure wrist bands were applied 30 min prior to induction of anesthesia and removed six hours following surgery. Anesthesia was standardized. PONV were evaluated separately as none, mild, moderate or severe within six hours of patients' arrival in the postanesthesia care unit and then at 24 hr after surgery by a blinded observer If patients vomited more than once, they were given 4 mg ondansetron iv as the rescue antiemetic.Results were analyzed by Z test. A P value of < 0.05 was taken as significant. Results: The incidence of PONV and the requirement of rescue medication were significantly lower in both the acupressure and ondansetron groups during the first six hours.Conclusion: Acupressure at P6 causes a significant reduction in the incidence of PONV and the requirement for rescue medication in the first six hours following laparoscopic cholecystectomy, similar to that of ondansetron 4 mg iv.

  DOI：

  10.1007/bf03017380

文献信息

• Guha; Rao, Journal of the Indian Institute of Science, 1939, vol. <A> 22, p. 326,329
  作者：Guha、Rao

  DOI：——

  日期：——
• Acupressure and ondansetron for postoperative nausea and vomiting after laparoscopic cholecystectomy
  作者：Anil Agarwal、Neeta Bose、Atul Gaur、Uttam Singh、Mithlesh Kumar Gupta、Dinesh Singh

  DOI：10.1007/bf03017380

  日期：2002.6

  Purpose: To compare the efficacy of acupressure wrist bands and ondansetron for the prevention of postoperative nausea and vomiting (PONV).Methods: One hundred and fifty ASA I-II, patients undergoing elective laparoscopic cholecystectomy were included in a randomized, prospective, double-blind and placebo-controlled study. Patients were divided into three groups of 50. Group I was the control; Group 11 received ondansetron 4 mg iv just prior to induction of anesthesia; in Group III acupressure wristbands were applied at the P6 points. Acupressure wrist bands Were placed inappropriately in Groups I and 11, The acupressure wrist bands were applied 30 min prior to induction of anesthesia and removed six hours following surgery. Anesthesia was standardized. PONV were evaluated separately as none, mild, moderate or severe within six hours of patients' arrival in the postanesthesia care unit and then at 24 hr after surgery by a blinded observer If patients vomited more than once, they were given 4 mg ondansetron iv as the rescue antiemetic.Results were analyzed by Z test. A P value of < 0.05 was taken as significant. Results: The incidence of PONV and the requirement of rescue medication were significantly lower in both the acupressure and ondansetron groups during the first six hours.Conclusion: Acupressure at P6 causes a significant reduction in the incidence of PONV and the requirement for rescue medication in the first six hours following laparoscopic cholecystectomy, similar to that of ondansetron 4 mg iv.