benzyl 3,5-dimethyl-4-[(S)-(1-methyl-but-3-enyloxycarbonyl)methyl]-1H-pyrrole-2-carboxylate | 871565-63-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzyl 3,5-dimethyl-4-[(S)-(1-methyl-but-3-enyloxycarbonyl)methyl]-1H-pyrrole-2-carboxylate
• 英文别名: benzyl 3,5-dimethyl-4-[2-oxo-2-[(2S)-pent-4-en-2-yl]oxyethyl]-1H-pyrrole-2-carboxylate
• CAS: 871565-63-8
• 化学式: C₂₁H₂₅NO₄
• 分子量: 355.434
• InChiKey: NXJRTGBAQHHGHE-AWEZNQCLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  26
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  68.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  benzyl 3,5-dimethyl-4-[(S)-(1-methyl-but-3-enyloxycarbonyl)methyl]-1H-pyrrole-2-carboxylate 在 palladium on activated charcoal 氢溴酸 、 氢气 作用下， 以 四氢呋喃 、 甲醇 、 水 为溶剂， 反应 16.33h， 生成
  参考文献：
  名称：

  Dinuclear Zinc(II) Double-Helicates of Homochirally Substituted Bis(dipyrromethene)s

  摘要：

  A series of bis(dipyrromethene)s substituted with aromatic amide and aliphatic ester homochiral auxiliaries have been prepared and complexed with zinc(II) ions to form double-helical dinuclear complexes. CD analysis of the crude complexes revealed that the helicates formed in a diastereo-selective manner. The helicates have been resolved into their constituent M and P helices by HPLC, indicating that the helical sense of the complexes is stable to racemization.

  DOI：

  10.1021/jo051727e
• 作为产物：
  描述：

  benzyl 4-ethanoic acid-3,5-dimethylpyrrole-2-carboxylate 、 (S)-(+)-4-戊烯-2-醇 在 4-二甲氨基吡啶 、 O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate 作用下， 以 四氢呋喃 为溶剂， 反应 48.0h， 以44%的产率得到benzyl 3,5-dimethyl-4-[(S)-(1-methyl-but-3-enyloxycarbonyl)methyl]-1H-pyrrole-2-carboxylate
  参考文献：
  名称：

  Dinuclear Zinc(II) Double-Helicates of Homochirally Substituted Bis(dipyrromethene)s

  摘要：

  A series of bis(dipyrromethene)s substituted with aromatic amide and aliphatic ester homochiral auxiliaries have been prepared and complexed with zinc(II) ions to form double-helical dinuclear complexes. CD analysis of the crude complexes revealed that the helicates formed in a diastereo-selective manner. The helicates have been resolved into their constituent M and P helices by HPLC, indicating that the helical sense of the complexes is stable to racemization.

  DOI：

  10.1021/jo051727e

文献信息

• Dinuclear Zinc(II) Double-Helicates of Homochirally Substituted Bis(dipyrromethene)s
  作者：Tabitha E. Wood、Avena C. Ross、Nathan D. Dalgleish、Erin D. Power、Alison Thompson、Xiaoming Chen、Yoshio Okamoto

  DOI：10.1021/jo051727e

  日期：2005.11.1

  A series of bis(dipyrromethene)s substituted with aromatic amide and aliphatic ester homochiral auxiliaries have been prepared and complexed with zinc(II) ions to form double-helical dinuclear complexes. CD analysis of the crude complexes revealed that the helicates formed in a diastereo-selective manner. The helicates have been resolved into their constituent M and P helices by HPLC, indicating that the helical sense of the complexes is stable to racemization.