α,α'-Dimethyl-cystin | 4727-05-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: α,α'-Dimethyl-cystin
• 英文别名: 2-Amino-3-[(2-amino-2-carboxypropyl)disulfanyl]-2-methylpropanoic acid
• CAS: 4727-05-3
• 化学式: C₈H₁₆N₂O₄S₂
• 分子量: 268.358
• InChiKey: CDTWGCLFGYMRDD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.9
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  177
• 氢给体数：
  4
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  S-Benzyl-α-methyl-D/L-cysteine 在 氨 、 sodium 作用下， 生成 α,α'-Dimethyl-cystin
  参考文献：
  名称：

  Arnstein, Biochemical Journal, 1958, vol. 68, p. 333,337

  摘要：

  DOI：

文献信息

• OPTICALLY ACTIVE 3,3 -DITHIOBIS(2-AMINO-2-METHYLPROPIONI C ACID) DERIVATIVE AND PROCESS FOR PRODUCING OPTICALLY ACTIVE 2-AMINO-3-MERCAPTO-2-METHYL-PROPIONIC ACID DERIVATIVE
  申请人：KANEKA CORPORATION

  公开号：EP1666458A1

  公开（公告）日：2006-06-07

  The present invention provides a useful novel intermediate and a novel synthetic process that can highly prevent contamination by various impurities to an optically active R or S isomer of a 2-amino-3-mercapto-2-methylpropionic acid derivative or salt thereof useful as an intermediate for pharmaceuticals and the like and provides a process for easily and efficiently producing a high purity optically active R or S isomer of a 2-amino-3-mercapto-2-methylpropionic acid derivative or salt thereof on an industrial production scale. A process of producing a high purity 2-amino-3-mercapto-2-methylpropionic acid derivative or salt thereof includes reductively cleaving a sulfur-sulfur bond of an intermediate, which is a high purity optically active 3,3'-dithiobis(2-amino-2-methylpropionic acid) derivative substantially free of impurities. Thus, a resulting optically active 2-amino-3-mercapto-2-methylpropionic acid derivative can be produced without generating impurities as by-products which are difficult to remove.

  本发明提供了一种有用的新型中间体和一种新的合成过程，可以高度防止各种杂质对光学活性的2-氨基-3-巯基-2-甲基丙酸衍生物或其盐（作为药物中间体等）的R或S异构体的污染，并提供了一种在工业生产规模上轻松高效地生产高纯度光学活性的2-氨基-3-巯基-2-甲基丙酸衍生物或其盐的过程。生产高纯度的2-氨基-3-巯基-2-甲基丙酸衍生物或其盐的过程包括还原地裂解中间体的硫-硫键，该中间体是高纯度的光学活性3,3'-二硫代(2-氨基-2-甲基丙酸)衍生物，几乎不含杂质。因此，可以生产出不产生难以去除的副产物杂质的光学活性的2-氨基-3-巯基-2-甲基丙酸衍生物。
• Optically active 3,3'-dithiobis(2-amino-2methylpropionic acid) derivative and process for producing optically active 2-amino-3-mercapto-2-methylpropionic acid derivative
  申请人：Matsumoto Shingo

  公开号：US20070010689A1

  公开（公告）日：2007-01-11

  The present invention provides a useful novel intermediate and a novel synthetic process that can highly prevent contamination by various impurities to an optically active R or S isomer of a 2-amino-3-mercapto-2-methylpropionic acid derivative or salt thereof useful as an intermediate for pharmaceuticals and the like and provides a process for easily and efficiently producing a high purity optically active R or S isomer of a 2-amino-3-mercapto-2-methylpropionic acid derivative or salt thereof on an industrial production scale. A process of producing a high purity 2-amino-3-mercapto-2-methylpropionic acid derivative or salt thereof includes reductively cleaving a sulfur-sulfur bond of an intermediate, which is a high purity optically active 3,3′-dithiobis(2-amino-2-methylpropionic acid) derivative substantially free of impurities. Thus, a resulting optically active 2-amino-3-mercapto-2-methylpropionic acid derivative can be produced without generating impurities as by-products which are difficult to remove.

  本发明提供了一种有用的新型中间体和一种新型合成方法，可以高度防止各种杂质对用作制药等中间体的2-氨基-3-巯基-2-甲基丙酸衍生物或其盐的光学活性R或S异构体的污染，并提供一种在工业生产规模上轻松高效地生产高纯度光学活性R或S异构体的2-氨基-3-巯基-2-甲基丙酸衍生物或其盐的过程。生产高纯度2-氨基-3-巯基-2-甲基丙酸衍生物或其盐的过程包括还原裂解中间体的硫-硫键，该中间体是高纯度的、基本无杂质的光学活性3,3'-二硫代双(2-氨基-2-甲基丙酸)衍生物。因此，可以生产出不生成难以去除的副产物杂质的光学活性2-氨基-3-巯基-2-甲基丙酸衍生物。
• MonoPEGylated human growth hormone
  申请人：Bolder Biotechnology, Inc.

  公开号：EP2305804A1

  公开（公告）日：2011-04-06

  The present invention relates to novel methods of making soluble proteins having free cysteines in which a host cell is exposed to a cysteine blocking agent. The soluble proteins produced by the methods can then be modified to increase their effectiveness. Such modifications include attaching a PEG moiety to form pegylated proteins.

  本发明涉及制造具有游离半胱氨酸的可溶性蛋白质的新方法，其中宿主细胞暴露于半胱氨酸阻断剂中。然后，可以对这些方法制得的可溶性蛋白质进行修饰，以提高其有效性。这种修饰包括连接 PEG 分子以形成聚乙二醇化蛋白质。
• Monopegylated growth hormone proteins
  申请人：Cox N. George

  公开号：US20050187160A1

  公开（公告）日：2005-08-25

  The present invention relates to novel methods of making soluble proteins having free cysteines in which a host cell is exposed to a cysteine blocking agent. The soluble proteins produced by the methods can then be modified to increase their effectiveness. Such modifications include attaching a PEG moiety to form pegylated proteins.

  本发明涉及制造具有游离半胱氨酸的可溶性蛋白质的新方法，其中宿主细胞暴露于半胱氨酸阻断剂中。然后，可以对这些方法制得的可溶性蛋白质进行修饰，以提高其有效性。这种修饰包括连接 PEG 分子以形成聚乙二醇化蛋白质。
• Lin'kova,M.G. et al., Doklady Chemistry, 1966, vol. 170, p. 836 - 838
  作者：Lin'kova,M.G. et al.

  DOI：——

  日期：——