N,N'-diethylterephthalamide | 6780-98-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N'-diethylterephthalamide
• 英文别名: N,N'-Diethyl-terephthalsaeure-diamid；1-N,4-N-diethylbenzene-1,4-dicarboxamide
• CAS: 6780-98-9
• 化学式: C₁₂H₁₆N₂O₂
• 分子量: 220.271
• InChiKey: AZSHNMRQTPKUKA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N,N'-diethylterephthalamide 在 氯化亚砜 作用下， 以 二氯甲烷 为溶剂， 生成 N,N,N',N'-tetraethyl-terephthalimidamide
  参考文献：
  名称：

  手性氢键超分子胶囊：C 70的合成，表征和络合

  摘要：

  通过新型双磷酸（R，R）-6与合适的双和三s啶的多组分自组装产生了两个超分子纳米胶囊。所得的手性氢键胶囊即使在极性介质中和低浓度下也稳定，可用于溶液中C 70-富勒烯的结合。

  DOI：

  10.1039/c8cc10152c
• 作为产物：
  描述：

  乙胺 、 对苯二甲酰氯 以 水 为溶剂， 反应 0.5h， 以90%的产率得到N,N'-diethylterephthalamide
  参考文献：
  名称：

  手性氢键超分子胶囊：C 70的合成，表征和络合

  摘要：

  通过新型双磷酸（R，R）-6与合适的双和三s啶的多组分自组装产生了两个超分子纳米胶囊。所得的手性氢键胶囊即使在极性介质中和低浓度下也稳定，可用于溶液中C 70-富勒烯的结合。

  DOI：

  10.1039/c8cc10152c

文献信息

• Molecular Pairs and A Propeller Containing Quadruply Bonded Dimolybdenum Units Linked by Polyamidate Ligands
  作者：F. Albert Cotton、Zhong Li、Chun Y. Liu、Carlos A. Murillo

  DOI：10.1021/ic0614723

  日期：2006.11.1

  Electrochemical measurements of these complexes show unresolved redox waves, which indicate that the dimetal centers are only electronically weakly coupled. Compound 1 was chemically oxidized by ferrocenium tetrafluoroborate to the two-electron oxidation product 4, where one electron was removed from each of the [Mo2] units. The hyperfine coupling in the EPR spectrum (A = 22 x 10-4 cm-1 ) suggests that 4 is an

  两个分子对[Mo2（DAniF）3] 2 [N，N'-对苯二甲酸乙二酰胺]（1）和[Mo2（DAniF）3] 2 1,3-C6H4 [C（O）NP]}（2）其中DAniF = N，N'-二对茴香基甲酰胺基）和螺旋桨（[Mo2（DAniF）3] 3 1,3,5-C6H3 [C（O）NPh] 3}（3））已经准备好通过将Mo2（DAniF）3（O2CCH3）与相应的聚酰胺酸酯直接结合，可得到高纯度的产品。这些配合物的电化学测量显示出未解析的氧化还原波，这表明双金属中心仅在电子上弱耦合。化合物1被四氟硼酸铁化学氧化成二电子氧化产物4，其中从每个[Mo2]单元中除去一个电子。EPR光谱中的超精细耦合（A = 22 x 10-4 cm-1）表明，4是一种电子俘获物种，在两个二钼单元中的每一个上都有一个电子，
• SMAC MIMETIC DIMERS AND TRIMERS USEFUL AS ANTI-CANCER AGENTS
  申请人：HANSON Gunnar

  公开号：US20090104151A1

  公开（公告）日：2009-04-23

  The invention provides small molecule mimics of the Smac peptide that are dimer-like or trimer-like compounds having two or three amide-containing domains connected by a linker. These compounds are useful to promote apoptosis. The invention includes pharmaceutical compositions comprising such compounds and methods to use them to treat conditions including cancer and autoimmune disorders.

  本发明提供了Smac肽的小分子模拟物，这些模拟物是二聚体或三聚体化合物，具有由连接剂连接的两个或三个含酰胺的结构域。这些化合物对促进细胞凋亡很有用。本发明还包括包含这些化合物的药物组成物和使用它们治疗包括癌症和自身免疫性疾病在内的疾病的方法。
• Smac mimetic dimers and trimers useful as anti-cancer agents
  申请人：Joyant Pharmaceuticals, Inc.

  公开号：US20140127155A1

  公开（公告）日：2014-05-08

  The invention provides small molecule mimics of the Smac peptide that are dimer-like or trimer-like compounds having two or three amide-containing domains connected by a linker. These compounds are useful to promote apoptosis. The invention includes pharmaceutical compositions comprising such compounds and methods to use them to treat conditions including cancer and autoimmune disorders.

  这项发明提供了Smac肽的小分子类似物，它们是二聚体或三聚体化合物，具有由连接剂连接的两个或三个含酰胺的结构域。这些化合物有助于促进细胞凋亡。该发明包括包含这些化合物的药物组合物和使用它们治疗癌症和自身免疫性疾病等病症的方法。
• Modifiable polyunsaturated polymers and processes for their preparation
  申请人：Parthiban Anbanandam

  公开号：US20060189774A1

  公开（公告）日：2006-08-24

  The present invention relates to modifiable linear polyunsaturated polymers and processes for preparing the same comprising reacting solely at least one bifunctional nucleophilic compound with at least one α-functional unsaturated monomer. The at least one bifunctional nucleophilic compound of the invention comprises two nucleophiles independently selected from the group consisting of C, N, O, S and Se. The at least one α-functional unsaturated monomer of the invention comprises two leaving groups L 1 and L 2 , wherein at least one of the leaving groups L 1 and L 2 of the at least one α-functional unsaturated monomer is part of the nonaromatic unsaturated structure C═C—C α -L. The double bond of said α-functional unsaturated monomer is maintained in the polyunsaturated polymer.

  本发明涉及可改性线性多不饱和聚合物以及制备该聚合物的工艺，包括仅使至少一种双官能团亲核化合物与至少一种α官能团不饱和单体反应。本发明的至少一种双官能团亲核化合物包括两个独立选自 C、N、O、S 和 Se 组的亲核物。本发明的至少一种 α-官能团不饱和单体包括两个离去基团 L 1 和 L 2 其中至少一个离去基团 L 1 和 L 2 的至少一个离去基团 L 1 和 L 2 是非芳香族不饱和结构 C═C-C α -L.所述 α-官能团不饱和单体的双键保留在多不饱和聚合物中。
• Hydrophobic, Salt-Like Structured Silicate
  申请人：Michel Eduard

  公开号：US20080107986A1

  公开（公告）日：2008-05-08

  A salt-like hydrophobic structured silicate, wherein the cation of the salt-like structured silicate is a low molecular weight organic cation or a combination thereof with NH 4 + , H 3 O + , alkali metal, alkaline earth metal, earth metal and/or a transition metal ion. The anion of the salt-like structured silicate is an island, ring, group, chain, band, layer or tectosilicate or a combination thereof. The structured silicate is produced by (a) reacting a structured silicate, whose cation is NH 4 + , H 3 O + , an alkali metal, alkaline earth metal, earth metal, and/or transition metal ion or a combination thereof, and whose anion of which is an island, ring, group, chain, band, layer or tectosilicate, or a combination thereof, in an aqueous dispersion with a low molecular weight organic cation; (b) adding to and intensively blending with the aqueous structured silicate dispersion a hydrophobic compound from the group of waxes and metal soaps in a quantity ranging from 0.2 to 200% by weight of the salt-like structured silicate in step (a) before, during and/or after step(a) is carried out and by (c) optionally removing, drying and isolating in the form of a powder the salt-like, hydrophobic structured silicate produced in step (b).