N-{2-[5-(4-Ethoxy-phenylethynyl)-pyridin-2-yl]-ethyl}-acetamide | 1363511-39-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-{2-[5-(4-Ethoxy-phenylethynyl)-pyridin-2-yl]-ethyl}-acetamide
• 英文别名: N-[2-[5-[2-(4-ethoxyphenyl)ethynyl]pyridin-2-yl]ethyl]acetamide
• CAS: 1363511-39-0
• 化学式: C₁₉H₂₀N₂O₂
• 分子量: 308.38
• InChiKey: PIUIOHCWEKEOLT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  51.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-[2-(5-bromo-pyridin-2-yl)-ethyl]-acetamide 、 4-乙炔基苯乙醚 在 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide N,N-二异丙基乙胺 作用下， 反应 0.17h， 生成 N-{2-[5-(4-Ethoxy-phenylethynyl)-pyridin-2-yl]-ethyl}-acetamide
  参考文献：
  名称：

  New compounds, pharmaceutical compositions and uses thereof

  摘要：

  这项发明涉及到公式I的新化合物及其作为药物的用途，以及用于治疗的方法和含有这些化合物的药物组合物。

  公开号：

  US20120214785A1

文献信息

• Compounds, pharmaceutical compositions and uses thereof
  申请人：Roth Gerald Juergen

  公开号：US08835472B2

  公开（公告）日：2014-09-16

  The invention relates to new compounds of the formula I to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.

  本发明涉及公式I的新化合物，它们的用途为药物，以及用于它们的治疗方法和包含它们的制药组合物。
• ALKYNYLPYRIDINE-SUBSTITUTED AMIDE COMPOUND AND NOXIOUS ORGANISM CONTROL AGENT
  申请人：Nissan Chemical Industries, Ltd.

  公开号：EP3109234A1

  公开（公告）日：2016-12-28

  Provided is a novel pesticide, particularly a fungicide and a nematicide. An alkynyl pyridine-substituted amide compound represented by formula (I), its N-oxide or a salt thereof, and a pesticide containing it. [In the formula, G1 is a structure represented by G1-1a, G1-3a, G1-27a, etc.; X1 is a halogen atom, difluoromethyl, trifluoromethyl, etc.; Y1 is a halogen atom, etc.; Y2, Y3, R4 and R5 independently represent a hydrogen atom, etc.; R1 is a hydrogen atom, a halogen atom, methyl, methoxy, etc.; R2 is a hydrogen atom, a halogen atom, etc., or R1 and R2 together form an alkylene chain thereby to form a cyclopropyl group together with the carbon atom to which R1 and R2 are bonded, or R1 and R2 together form C1-C2 alkylidene or C1-C2 haloalkylidene; R3 is a hydrogen atom, methyl, etc.; and R6 is C1-C4 alkyl, C3-C6 cycloalkyl, C1-C4 alkoxy(C1-C4)alkyl, etc.]

  本发明提供了一种新型农药，特别是一种杀真菌剂和杀线虫剂。一种由式（I）代表的炔基吡啶取代酰胺化合物、其 N-氧化物或其盐，以及一种含有该化合物的农药。[式中，G1 是由 G1-1a、G1-3a、G1-27a 等代表的结构；X1 是卤素原子、二氟甲基、三氟甲基等；Y1 是卤素原子等；Y2、Y3、R4 和 R5 独立地代表氢原子等；R1 是氢原子、卤素原子、甲基、甲氧基等；R2 是氢原子、卤素原子等、或 R1 和 R2 一起形成亚烷基链，从而与 R1 和 R2 键合的碳原子一起形成环丙基，或 R1 和 R2 一起形成 C1-C2 亚烷基或 C1-C2 卤代亚烷基；R3 是氢原子、甲基等；R6 是 C1-C4 烷基、C3-C6 环烷基、C1-C4 烷氧基（C1-C4）烷基等。］
• Alkynyl pyridine-substituted amide compound and pesticide
  申请人：NISSAN CHEMICAL INDUSTRIES, LTD.

  公开号：US10029986B2

  公开（公告）日：2018-07-24

  Provided is a novel pesticide, particularly a fungicide and a nematicide. An alkynyl pyridine-substituted amide compound represented by formula (I), its N-oxide or a salt thereof, and a pesticide containing it. [In the formula, G1 is a structure represented by G1-1a, G1-3a, G1-27a, etc.; X1 is a halogen atom, difluoromethyl, trifluoromethyl, etc.; Y1 is a halogen atom, etc.; Y2, Y3, R4 and R5 independently represent a hydrogen atom, etc.; R1 is a hydrogen atom, a halogen atom, methyl, methoxy, etc.; R2 is a hydrogen atom, a halogen atom, etc., or R1 and R2 together form an alkylene chain thereby to form a cyclopropyl group together with the carbon atom to which R1 and R2 are bonded, or R1 and R2 together form C1-C2 alkylidene or C1-C2 haloalkylidene; R3 is a hydrogen atom, methyl, etc.; and R6 is C1-C4 alkyl, C3-C6 cycloalkyl, C1-C4 alkoxy(C1-C4)alkyl, etc.]

  本发明提供了一种新型农药，特别是一种杀真菌剂和杀线虫剂。一种由式（I）代表的炔基吡啶取代酰胺化合物、其 N-氧化物或其盐，以及一种含有该化合物的农药。[式中，G1 是由 G1-1a、G1-3a、G1-27a 等代表的结构；X1 是卤素原子、二氟甲基、三氟甲基等；Y1 是卤素原子等；Y2、Y3、R4 和 R5 独立地代表氢原子等；R1 是氢原子、卤素原子、甲基、甲氧基等；R2 是氢原子、卤素原子等、或 R1 和 R2 一起形成亚烷基链，从而与 R1 和 R2 键合的碳原子一起形成环丙基，或 R1 和 R2 一起形成 C1-C2 亚烷基或 C1-C2 卤代亚烷基；R3 是氢原子、甲基等；R6 是 C1-C4 烷基、C3-C6 环烷基、C1-C4 烷氧基（C1-C4）烷基等。］
• SUBSTITUTED HETEROARYL- AND ARYLALKYNYL BENZENE DERIVATIVES AS ACC-INHIBITORS FOR THE TREATMENT OF METABOLIC DISEASES
  申请人：Boehringer Ingelheim International GmbH

  公开号：EP2611771B1

  公开（公告）日：2016-11-23
• ALKYNYL PYRIDINE-SUBSTITUTED AMIDE COMPOUND AND PESTICIDE
  申请人：NISSAN CHEMICAL INDUSTRIES, LTD.

  公开号：US20170008847A1

  公开（公告）日：2017-01-12

  Provided is a novel pesticide, particularly a fungicide and a nematicide. An alkynyl pyridine-substituted amide compound represented by formula (I), its N-oxide or a salt thereof, and a pesticide containing it. [In the formula, G 1 is a structure represented by G 1 -1a, G 1 -3a, G 1 -27a, etc.; X 1 is a halogen atom, difluoromethyl, trifluoromethyl, etc.; Y 1 is a halogen atom, etc.; Y 2 , Y 3 , R 4 and R 5 independently represent a hydrogen atom, etc.; R 1 is a hydrogen atom, a halogen atom, methyl, methoxy, etc.; R 2 is a hydrogen atom, a halogen atom, etc., or R 1 and R 2 together form an alkylene chain thereby to form a cyclopropyl group together with the carbon atom to which R 1 and R 2 are bonded, or R 1 and R 2 together form C 1 -C 2 alkylidene or C 1 -C 2 haloalkylidene; R 3 is a hydrogen atom, methyl, etc.; and R 6 is C 1 -C 4 alkyl, C 3 -C 6 cycloalkyl, C 1 -C 4 alkoxy(C 1 -C 4 )alkyl, etc.]