N-(3-(2-甲基噻唑-4-基)苯基)乙酰胺 | 312925-73-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-(3-(2-甲基噻唑-4-基)苯基)乙酰胺
• 英文名称: N-(3-(2-methylthiazol-4-yl)phenyl)acetamide
• 英文别名: N-[3-(2-methyl-1,3-thiazol-4-yl)phenyl]acetamide
• CAS: 312925-73-8
• 化学式: C₁₂H₁₂N₂OS
• mdl: MFCD00533123
• 分子量: 232.306
• InChiKey: PUSUTGRMXCRLGA-UHFFFAOYSA-N

物化性质

• 沸点：
  464.6±28.0 °C(Predicted)
• 密度：
  1.243±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.166
• 拓扑面积：
  70.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(3-(2-甲基噻唑-4-基)苯基)乙酰胺 在 盐酸 、 水 作用下， 生成 3-(2-甲基-1,3-噻唑-4-基)苯胺
  参考文献：
  名称：

  Synthesis and Anticancer Activities of Some Thiazole Derivatives

  摘要：

  In this study, 2-substituted 4-[3/4-(4-arylthiazole-2-yl) aminophenyl] thiazole derivatives and 2-[4-[2-substituted 4-methylthiazole-5-yl]thiazole-2-yl] amino-5-arylidenethiazoline-4-one derivatives have been synthesized. The cytotoxic and/or growth inhibitory effects of the 16 selected compounds were evaluated in vitro against approximately 66 human tumor cell lines derived from nine neoplastic diseases. Some of the compounds were found to act as anticancer agents.

  DOI：

  10.1080/10426500802446181
• 作为产物：
  描述：

  3-(2-甲基-1,3-噻唑-4-基)苯胺 在 2,6-二甲基吡啶 、 亚硝酸特丁酯 、 叠氮基三甲基硅烷 作用下， 以 水 、 乙腈 为溶剂， 反应 0.83h， 生成 N-(3-(2-甲基噻唑-4-基)苯基)乙酰胺
  参考文献：
  名称：

  Continuous Flow Synthesis of Secondary Amides by Tandem Azidation- Amidation of Anilines

  摘要：

  The continuous flow synthesis of a variety of secondary amides by tandem azidation-amidation of anilines is described. This new procedure benefits from the improved safety feature of generating aromatic azides in flow, thus ensuring low concentrations of any potentially hazardous intermediates. The protocol was amenable to the production of multi-gram quantities of the amide product.

  DOI：

  10.1055/s-0031-1291013

文献信息

• 2-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS
  申请人：Aissaoui Hamed

  公开号：US20110124636A1

  公开（公告）日：2011-05-26

  The invention relates to novel 2-aza-bicyclo[3.1.0]hexane derivatives of Formula (I) wherein A, B, n and R 1 are as described in the description, and to the use of such compounds, or of pharmaceutically acceptable salts of such compounds, as medicaments, especially as orexin receptor antagonists.

  该发明涉及一种新型2-aza-bicyclo[3.1.0]己烷衍生物，其化学式为（I），其中A、B、n和R1如说明书所述，并且涉及使用这种化合物或这种化合物的药学上可接受的盐作为药物，特别是作为促进睡眠的药物。
• Energy-resolved mass spectrometry to investigate nucleobase triplexes – a study applied to triplex-forming artificial nucleobases
  作者：Mauro Safir Filho、Lionel Massi、Antoine Millet、Dylan Michel、Wafa Moussa、Cyril Ronco、Rachid Benhida

  DOI：10.1039/d2nj00665k

  日期：——

  This paper discloses the use of an energy-resolved mass spectrometric-based approach to assess the stabilities of base triplexes encompassing artificial nucleobases by using variable energy collision-induced dissociation.

  本文揭示了使用基于能量分辨质谱的方法来评估含有人工核苷酸的碱基三联体稳定性的方法，该方法利用可变能量碰撞诱导解离。
• US8288435B2
  申请人：——

  公开号：US8288435B2

  公开（公告）日：2012-10-16
• Synthesis and Anticancer Activities of Some Thiazole Derivatives
  作者：Ismail Kayagil、Seref Demirayak

  DOI：10.1080/10426500802446181

  日期：2009.9.18

  In this study, 2-substituted 4-[3/4-(4-arylthiazole-2-yl) aminophenyl] thiazole derivatives and 2-[4-[2-substituted 4-methylthiazole-5-yl]thiazole-2-yl] amino-5-arylidenethiazoline-4-one derivatives have been synthesized. The cytotoxic and/or growth inhibitory effects of the 16 selected compounds were evaluated in vitro against approximately 66 human tumor cell lines derived from nine neoplastic diseases. Some of the compounds were found to act as anticancer agents.
• Continuous Flow Synthesis of Secondary Amides by Tandem Azidation- Amidation of Anilines
  作者：John Moses、Christian Spiteri

  DOI：10.1055/s-0031-1291013

  日期：2012.6

  The continuous flow synthesis of a variety of secondary amides by tandem azidation-amidation of anilines is described. This new procedure benefits from the improved safety feature of generating aromatic azides in flow, thus ensuring low concentrations of any potentially hazardous intermediates. The protocol was amenable to the production of multi-gram quantities of the amide product.