(R)-2-(4-chloro-N-(4-methoxybenzyl)phenylsulfonamido)-N-methoxy-N,4-dimethylpentanamide | 1408001-33-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (R)-2-(4-chloro-N-(4-methoxybenzyl)phenylsulfonamido)-N-methoxy-N,4-dimethylpentanamide
• 英文别名: (2R)-2-[(4-chlorophenyl)sulfonyl-[(4-methoxyphenyl)methyl]amino]-N-methoxy-N,4-dimethylpentanamide
• CAS: 1408001-33-1
• 化学式: C₂₂H₂₉ClN₂O₅S
• 分子量: 469.002
• InChiKey: MUAIRXODEYSJEV-OAQYLSRUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  31
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  84.5
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  (R)-2-(4-chloro-N-(-4-methoxybenzyl)phenylsulfonamido)-4-methylpentanoic acid 、 二甲羟胺盐酸盐 在 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 以24%的产率得到(R)-2-(4-chloro-N-(4-methoxybenzyl)phenylsulfonamido)-N-methoxy-N,4-dimethylpentanamide
  参考文献：
  名称：

  2-(N-Benzyl-N-phenylsulfonamido)alkyl amide derivatives as γ-secretase inhibitors

  摘要：

  A series of (N-benzyl-N-phenylsulfonamido)alkyl amides were developed from classic and parallel synthesis strategies. Compounds with good in vitro and in vivo gamma-secretase activity were identified and described. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.09.057

文献信息

• 2-(N-Benzyl-N-phenylsulfonamido)alkyl amide derivatives as γ-secretase inhibitors
  作者：Michael F. Parker、Donna M. Barten、Carl P. Bergstrom、Joanne J. Bronson、Jason A. Corsa、Michael F. Dee、Yonghua Gai、Valerie L. Guss、Mendi A. Higgins、Daniel J. Keavy、Alice Loo、Robert A. Mate、Larry R. Marcin、Katharine E. McElhone、Craig T. Polson、Susan B. Roberts、John E. Macor

  DOI：10.1016/j.bmcl.2012.09.057

  日期：2012.11

  A series of (N-benzyl-N-phenylsulfonamido)alkyl amides were developed from classic and parallel synthesis strategies. Compounds with good in vitro and in vivo gamma-secretase activity were identified and described. (C) 2012 Elsevier Ltd. All rights reserved.