Carbazinsaeureisobutylester | 54662-03-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Carbazinsaeureisobutylester
• 英文别名: hydrazinecarboxylic acid isobutyl ester；2-methylpropyl N-aminocarbamate
• CAS: 54662-03-2
• 化学式: C₅H₁₂N₂O₂
• 分子量: 132.162
• InChiKey: ABTXUKOYJCIDQU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  64.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Carbazinsaeureisobutylester 在 吡啶 、 N-溴代丁二酰亚胺(NBS) 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 生成 isobutyl phenylaminocarbonyldiazenecarboxylate
  参考文献：
  名称：

  ZrCl₄-Mediated Regioselective Electrophilic Amination of Activated Arenes with New Alkyl Arylaminocarbonyldiazenecarboxylates:  Intermolecular and Intramolecular Reactions

  摘要：

  DOI：

  10.1021/jo9821170
• 作为产物：
  描述：

  1H-imidazole-1-carboxylic acid 2-methylpropyl ester 在 一水合肼 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 生成 Carbazinsaeureisobutylester
  参考文献：
  名称：

  N杂环取代基指示的芳烃与芳烃的钯催化氧化C–H烷氧基羰基化反应

  摘要：

  我们报告了一种环境友好的方案，用于芳烃的C–H烷氧基羰基化与由N-杂环取代基指示的烷基氨基甲酸酯。Pd（OAc）2用于催化这种氧化性自由基的羰基化转化。该反应可耐受多种官能团，从而以高收率和优异的区域选择性提供产物。

  DOI：

  10.1002/ejoc.202000530

文献信息

• [EN] SYNTHESIS METHODS AND INTERMEDIATES FOR THE MANUFACTURE OF RIZATRIPTAN<br/>[FR] PROCEDES DE SYNTHESE ET PRODUITS INTERMEDIAIRES POUR PRODUIRE DU RIZATRIPTAN
  申请人：RATIOPHARM GMBH

  公开号：WO2005075422A1

  公开（公告）日：2005-08-18

  The invention relates to a process for the manufacture of an 1,2,4-triazol-1-yl compound of the formula [A], or a salt thereof, wherein each of R3 and R4 is hydrogen or lower alkyl, said process comprising reacting a hydrazine compound of the formula [B] wherein R is hydrogen or acyl, R2 is hydrogen or a protecting group, are hydrogen or lower alkyl, and R6 is hydrogen or COOR7, or a salt thereof, with a 1,2,4-triazolyl forming reagent. In addition, novel intermediates for the synthesis of the anti-migraine agent Rizatriptan and methods for their synthesis are presented.

  本发明涉及一种制备式[A]的1,2,4-三唑-1-基化合物或其盐的工艺，其中R3和R4各自是氢或低级烷基，所述工艺包括将式[B]的肼化合物与1,2,4-三唑基形成剂反应，其中R是氢或酰基，R2是氢或保护基团，是氢或低级烷基，R6是氢或COOR7，或其盐。另外，还提供了一种用于合成抗偏头痛药物利扎曲普坦的新颖中间体及其合成方法。
• Reagents for graft copolymers
  申请人：The Malaysian Rubber Producers' Research Association

  公开号：US04501860A1

  公开（公告）日：1985-02-26

  A hydroxyl-functional polymer is reacted with a compound ZCO.N(H).sub.x.N(H).sub.x.CO.OR, where Z is halogen or aryloxy, x is 0 or 1 and R is hydrocarbon, and the reaction product is if necessary oxidized to give an azodicarboxylate functional polymer having the formula QOCO.N:N.CO.OR where Q is an inert polymer group. This polymer is used to react with ethylenically unsaturated natural or synthetic rubber so as to graft groups derived from the polymer on the rubber backbone.

  一种羟基官能团聚合物与化合物ZCO.N(H).sub.x.N(H).sub.x.CO.OR反应，其中Z是卤素或芳氧基，x为0或1，R为碳氢化合物，必要时将反应产物氧化，得到具有公式QOCO.N:N.CO.OR的偶氮二羧酸酯官能团聚合物，其中Q是惰性聚合物基团。该聚合物用于与具有乙烯基不饱和性的天然或合成橡胶反应，以将来自聚合物的基团嫁接到橡胶主链上。
• Synthesis methods and intermediates for the manufacture of rizatriptan
  申请人：Martin Pierre

  公开号：US20070123711A1

  公开（公告）日：2007-05-31

  The invention relates to a process for the manufacture of an 1,2,4-triazol-1-yl compound of the formula [A], or a salt thereof, wherein each of R3 and R4 is hydrogen or lower alkyl, said process comprising reacting a hydrazine compound of the formula [B] wherein R is hydrogen or acyl, R2 is hydrogen or a protecting group, are hydrogen or lower alkyl, and R6 is hydrogen or COOR7, or a salt thereof, with a 1,2,4-triazolyl forming reagent. In addition, novel intermediates for the synthesis of the anti-migraine agent Rizatriptan and methods for their synthesis are presented.

  本发明涉及一种制备式[A]的1,2,4-三唑-1-基化合物或其盐的方法，其中R3和R4中的每一个是氢或低碳基，该方法包括将式[B]的腙化合物与1,2,4-三唑基形成试剂反应，其中R为氢或酰基，R2为氢或保护基，R5和R6为氢或COOR7，或其盐。此外，本发明还提供了用于合成抗偏头痛药利扎替普坦的新中间体及其合成方法。
• Synthesis methods and intermediates for the manufacture of Rizatriptan
  申请人：ratiopharm GmbH

  公开号：US07786156B2

  公开（公告）日：2010-08-31

  The invention relates to a process for the manufacture of an 1,2,4-triazol-1-yl compound of the formula [A], or a salt thereof, wherein each of R3 and R4 is hydrogen or lower alkyl, said process comprising reacting a hydrazine compound of the formula [B] wherein R is hydrogen or acyl, R2 is hydrogen or a protecting group, are hydrogen or lower alkyl, and R6 is hydrogen or COOR7, or a salt thereof, with a 1,2,4-triazolyl forming reagent. In addition, novel intermediates for the synthesis of the anti-migraine agent Rizatriptan and methods for their synthesis are presented.

  本发明涉及一种制备公式[A]的1,2,4-三唑-1-基化合物或其盐的方法，其中R3和R4中的每一个是氢或低碳基，该方法包括将公式[B]的肼化合物与1,2,4-三唑基形成试剂反应，其中R为氢或酰基，R2为氢或保护基，R5和R6为氢或低碳基，R7为氢或COOR7，或其盐。此外，本发明还提供了用于合成抗偏头痛药利扎替普坦的新中间体以及其合成方法。
• Electrochemically promoted annulation of aldehydes and carbazates: access to 2-alkoxy/aryloxy-5-substituted 1,3,4-oxadiazole and 1,3,4-oxadiazol-2(3<i>H</i>)-one derivatives
  作者：Hongjun Li、Dong Tang、Zafar Iqbal、Yaya Wan、Rui Jiang、Zhixiang Yang、Jinhui Yang

  DOI：10.1039/d2nj04113h

  日期：——

  The strategy is oxidant-free and transition-metal free, offering the electrolyte-free completion of the reaction at room temperature. A possible mechanism has been proposed based on control-experiment results and literature reports. The practical utility of this approach is highlighted via the brief synthesis of 5-(4-chloro-3-(trifluoromethyl)phenyl)-1,3,4-oxadiazol-2(3H)-one, which is a potent inhibitor

  通过醛的环化，开发了一种高效且环保的化学和药学上有趣的 2-烷氧基/芳氧基-1,3,4-恶二唑和 1,3,4-恶二唑-2(3 H )-酮的合成方法和卡巴酸盐。该协议涉及以电化学方式促进以良好至优异的产量获得所需产品。该方法使用 NaBr 作为电催化剂，MeOH 作为溶剂。该策略不含氧化剂和过渡金属，可在室温下无电解质完成反应。基于对照实验结果和文献报道提出了一种可能的机制。通过5-(4-chloro-3-(trifluoromethyl)phenyl)-1,3,4-oxadiazol-2( 3 H)-one，它是 Notum 羧酸酯酶活性的有效抑制剂。