Benzoic acid [1-(3-chloro-phenyl)-meth-(E)-ylidene]-hydrazide | 39575-05-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Benzoic acid [1-(3-chloro-phenyl)-meth-(E)-ylidene]-hydrazide
• 英文别名: n'-(3-Chlorobenzylidene)benzohydrazide；N-[(E)-(3-chlorophenyl)methylideneamino]benzamide
• CAS: 39575-05-8
• 化学式: C₁₄H₁₁ClN₂O
• 分子量: 258.707
• InChiKey: ISYSUJPWVBUSQX-MHWRWJLKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  41.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Benzoic acid [1-(3-chloro-phenyl)-meth-(E)-ylidene]-hydrazide 在 potassium permanganate 作用下， 以 水 、 丙酮 为溶剂， 反应 0.2h， 以90%的产率得到2-(3-氯苯基)-5-苯基-1,3,4-恶二唑
  参考文献：
  名称：

  微波辅助合成2,5-二取代1,3,4-恶二唑

  摘要：

  通过在固体矿物载体的表面上以及在丙酮和水的混合物中于微波辐射下用高锰酸钾氧化1-芳基-2-亚芳基肼来合成2,5-二取代的1,3,4-恶二唑。

  DOI：

  10.1016/j.tetlet.2004.09.095
• 作为产物：
  描述：

  苯甲酰肼 、 3-氯苯甲醛 在 磷酸 作用下， 以 乙醇 为溶剂， 反应 0.2h， 以91%的产率得到Benzoic acid [1-(3-chloro-phenyl)-meth-(E)-ylidene]-hydrazide
  参考文献：
  名称：

  微波辅助合成2,5-二取代1,3,4-恶二唑

  摘要：

  通过在固体矿物载体的表面上以及在丙酮和水的混合物中于微波辐射下用高锰酸钾氧化1-芳基-2-亚芳基肼来合成2,5-二取代的1,3,4-恶二唑。

  DOI：

  10.1016/j.tetlet.2004.09.095

文献信息

• Aza-Michael Addition Reactions of Hydrazones with Activated Alkynes Catalyzed by Nitrogen-Containing Organic Bases
  作者：Zhi-Liang Yuan、Yin Wei、Min Shi

  DOI：10.1002/ejoc.201000365

  日期：2010.7

  2]-octane)-catalyzed Michael-type reactions of hydrazones with activated alkynes are described in this paper. This aza-Michael addition reaction can be applied to different types of hydrazones, such as hydrazones 1 and hydroxy-bearing hydrazones 5. The corresponding adducts are achieved in high yields under mild reaction conditions. DABCO-promoted aza-Michael addition reactions were successfully applied to

  本文描述了几种高效的 DABCO（1,4-二氮杂双环 [2.2.2]-辛烷）催化腙与活化炔烃的迈克尔型反应。这种氮杂-迈克尔加成反应可以应用于不同类型的腙，如腙1和含羟基的腙5。相应的加合物在温和的反应条件下以高产率获得。DABCO 促进的氮杂-迈克尔加成反应成功地应用于一系列具有活化炔烃的腙，以中等至良好的产率提供相应的加合物。
• Badawy, Mohamed A.; El-Bahaie, Said A.; Kadry, Azza M., Heterocycles, 1988, vol. 27, # 1, p. 7 - 10
  作者：Badawy, Mohamed A.、El-Bahaie, Said A.、Kadry, Azza M.、Ibrahim, Yehia A.

  DOI：——

  日期：——
• KUMAR, ATUL;SINGH, S.;VERMA, M.;SAXENA, A. K.;SHANKER, K., INDIAN J. PHARM. SCI., 49,(1987) N 6, 201-204
  作者：KUMAR, ATUL、SINGH, S.、VERMA, M.、SAXENA, A. K.、SHANKER, K.

  DOI：——

  日期：——
• Systematic identification of new anti-prion drugs by high-throughput screening based on scanning for intensely fluorescent targets (sift)
  申请人：Bertsch Uwe

  公开号：US20100029773A1

  公开（公告）日：2010-02-04

  The present invention relates to a method of identifying a compound for inhibiting aggregation of proteins involved in diseases linked to protein aggregation and/or neurodegenerative diseases, comprising the steps of: (a) bringing into contact a labeled monomeric protein and a differently labeled aggregate of said protein in the (1) presence and (2) absence of a candidate inhibitor of aggregation, (b) determining the amount of co-localized labels, representing the extent of binding of the monomeric proteins to the aggregates of said protein; and (c) comparing the result obtained in the presence and absence of said compound, wherein a decrease of co-localized labels in the presence of said compound is indicative of the compound's ability to inhibit aggregation of said protein. Moreover, the present invention relates to a pharmaceutical composition containing said inhibitor of aggregation as well as to a kit.