3-Aethyl-5-hydroxyindan | 65021-20-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 3-Aethyl-5-hydroxyindan
• 英文别名: 3-ethyl-5-hydroxyindane；3-Ethyl-5-hydroxy-indane；3-ethyl-2,3-dihydro-1H-inden-5-ol
• CAS: 65021-20-7
• 化学式: C₁₁H₁₄O
• 分子量: 162.232
• InChiKey: DGQCDUXODFHJFV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-Aethyl-5-hydroxyindan 在 氢氧化钾 、 三乙胺 作用下， 以 水 、 N,N-二甲基甲酰胺 、 叔丁醇 为溶剂， 反应 4.0h， 生成 1-[3-(3-Ethyl-indan-5-yloxy)-propyl]-4-(4-fluoro-phenyl)-piperazine
  参考文献：
  名称：

  Synthesis and antianxiety activity of (.omega.-piperazinylalkoxy)indan derivatives

  摘要：

  A series of (omega-piperazinylalkoxy)indan derivatives has been synthesized and screened for potential antianxiety activities. The effect of structural modification of these molecules on activities has been systemically examined. Antianxiety activity was displayed by 5-[3-(4-phenyl-1-piperazinyl)propoxy]indan (2), 5-[3-[4-(4-fluorophenyl)-1-piperazinyl]-propoxy]indan (8), 6-fluoro-5-[3-(4-phenyl-1-piperazinyl)propoxy]indan (33), and 6-methyl-5-[3-(4-phenyl-1-piperazinyl)propoxy]indan (42), as determined in antifighting and anti-morphine tests. These derivatives in antianxiety tests were equipotent or more potent than chlordiazepoxide with less muscle-relaxant effect. They also showed weak neuroleptic-like action.

  DOI：

  10.1021/jm00356a024
• 作为产物：
  描述：

  3-ethyl-5-methoxy-indane 、 吡啶盐酸盐 在 氯仿 作用下， 以 水 为溶剂， 反应 5.0h， 以gave 32 g of 3-ethyl-5-hydroxy-indane的产率得到3-Aethyl-5-hydroxyindan
  参考文献：
  名称：

  Indan-5-yl-N-methylcarbamic acid esters

  摘要：

  式为##STR1##的Indan-5-yl-N-甲基氨基甲酸酯，其中R代表氢或C.sub.1-C.sub.4烷基，R.sup.1代表氢或C.sub.1-C.sub.4烷基，R.sup.2代表C.sub.1-C.sub.4烷基，R.sup.3代表氢或C.sub.1-C.sub.4烷基，R.sup.4代表氢、氯、溴、C.sub.1-C.sub.4烷基或C.sub.1-C.sub.4烷氧基。该化合物具有杀虫和杀真菌的特性。

  公开号：

  US04107324A1

文献信息

• KIKUMOTO, RYOJI;TOBE, AKIHIRO;FUKAMI, HARUKAZU;EGAWA, MITSUO, J. MED. CHEM., 1983, 26, N 2, 246-250
  作者：KIKUMOTO, RYOJI、TOBE, AKIHIRO、FUKAMI, HARUKAZU、EGAWA, MITSUO

  DOI：——

  日期：——
• US4107324A
  申请人：——

  公开号：US4107324A

  公开（公告）日：1978-08-15
• Synthesis and antianxiety activity of (.omega.-piperazinylalkoxy)indan derivatives
  作者：Ryoji Kikumoto、Akihiro Tobe、Harukazu Fukami、Mitsuo Egawa

  DOI：10.1021/jm00356a024

  日期：1983.2

  A series of (omega-piperazinylalkoxy)indan derivatives has been synthesized and screened for potential antianxiety activities. The effect of structural modification of these molecules on activities has been systemically examined. Antianxiety activity was displayed by 5-[3-(4-phenyl-1-piperazinyl)propoxy]indan (2), 5-[3-[4-(4-fluorophenyl)-1-piperazinyl]-propoxy]indan (8), 6-fluoro-5-[3-(4-phenyl-1-piperazinyl)propoxy]indan (33), and 6-methyl-5-[3-(4-phenyl-1-piperazinyl)propoxy]indan (42), as determined in antifighting and anti-morphine tests. These derivatives in antianxiety tests were equipotent or more potent than chlordiazepoxide with less muscle-relaxant effect. They also showed weak neuroleptic-like action.
• Indan-5-yl-N-methylcarbamic acid esters
  申请人：Bayer Aktiengesellschaft

  公开号：US04107324A1

  公开（公告）日：1978-08-15

  Indan-5-yl-N-methylcarbamic acid esters of the formula ##STR1## in which R represents hydrogen or C.sub.1 -C.sub.4 alkyl, R.sup.1 represents hydrogen or C.sub.1 -C.sub.4 alkyl, R.sup.2 represents C.sub.1 -C.sub.4 alkyl, R.sup.3 represents hydrogen or C.sub.1 -C.sub.4 alkyl and R.sup.4 represents hydrogen, chlorine, bromine, C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy, Which possess arthropodicidal and fungicidal properties.

  式为##STR1##的Indan-5-yl-N-甲基碳酸酯，其中R代表氢或C.sub.1-C.sub.4烷基，R.sup.1代表氢或C.sub.1-C.sub.4烷基，R.sup.2代表C.sub.1-C.sub.4烷基，R.sup.3代表氢或C.sub.1-C.sub.4烷基，R.sup.4代表氢，氯，溴，C.sub.1-C.sub.4烷基或C.sub.1-C.sub.4烷氧基，具有杀虫和杀真菌性能。