[2-[(3-carbamoyl-6-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)amino]-2-oxoethyl] 2-(1H-indol-3-yl)acetate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: [2-[(3-carbamoyl-6-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)amino]-2-oxoethyl] 2-(1H-indol-3-yl)acetate
• 化学式: C₂₂H₂₃N₃O₄S
• 分子量: 425.5
• InChiKey: BVZVAMUAJUTFOV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  143
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Cyclopentathiophene/cyclohexathiophene DNA methyltransferase inhibitors
  申请人：Vankayalapati Hariprasad

  公开号：US20100222381A1

  公开（公告）日：2010-09-02

  Compounds represented by Formula (I): are useful in treating diseases, such as cancer, that are mediated and/or associated (at least in part) with DNMT3b activity. The compounds can be formulated as pharmaceutically acceptable compositions for administration to a subject in need thereof.

  由式（I）表示的化合物在治疗疾病方面很有用，例如癌症，这些疾病与DNMT3b活性有关。这些化合物可以制备成药学上可接受的组合物，用于向需要的受试者施用。
• [EN] CYCLOPENTATHIOPHENE/CYCLOHEXATHIOPHENE DNA METHYLTRANSFERASE INHIBITORS<br/>[FR] INHIBITEURS CYCLOPENTATHIOPHÈNE/CYCLOHEXATHIOPHÈNE DE L'ADN MÉTHYLTRANSFÉRASE
  申请人：SUPERGEN INC

  公开号：WO2010098866A1

  公开（公告）日：2010-09-02

  Compounds represented by Formula (I): are useful in treating diseases, such as cancer, that are mediated and/or associated (at least in part) with DNMT3b activity. The compounds can be formulated as pharmaceutically acceptable compositions for administration to a subject in need thereof.