4-Amino-benzoic acid [1-(4-hydroxy-3-methoxy-phenyl)-meth-(E)-ylidene]-hydrazide | 97742-10-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-Amino-benzoic acid [1-(4-hydroxy-3-methoxy-phenyl)-meth-(E)-ylidene]-hydrazide
• 英文别名: 4-amino-N-[(4-hydroxy-3-methoxyphenyl)methylideneamino]benzamide
• CAS: 97742-10-4
• 化学式: C₁₅H₁₅N₃O₃
• 分子量: 285.302
• InChiKey: SDHHGPJCZIHEIP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  96.9
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  吲哚 、 4-Amino-benzoic acid [1-(4-hydroxy-3-methoxy-phenyl)-meth-(E)-ylidene]-hydrazide 在 盐酸 、 氢氧化钾 、 sodium nitrite 作用下， 生成 4-(1H-Indol-3-ylazo)-benzoic acid [1-(4-hydroxy-3-methoxy-phenyl)-meth-(E)-ylidene]-hydrazide
  参考文献：
  名称：

  Jani; Undavia; Trivedi, Journal of the Indian Chemical Society, 1990, vol. 67, # 7, p. 601 - 602

  摘要：

  DOI：
• 作为产物：
  描述：

  苯佐卡因 在 一水合肼 作用下， 以 乙醇 为溶剂， 反应 6.0h， 生成 4-Amino-benzoic acid [1-(4-hydroxy-3-methoxy-phenyl)-meth-(E)-ylidene]-hydrazide
  参考文献：
  名称：

  Synthesis, Anti-inflammatory, and Neuroprotective Activity of N-Substituted Phthalimide Derivatives

  摘要：

  DOI：

  10.1134/s1070363223110257

文献信息

• [EN] THE EXOCYST AS A NOVEL DRUG TARGET OF ENDOSIDIN2 AND APPLICATION AS A THERAPEUTIC<br/>[FR] L'EXOKYSTE EN TANT QUE NOUVELLE CIBLE DE MÉDICAMENT DE L'ENDOSIDINE-2 ET APPLICATION THÉRAPEUTIQUE
  申请人：UNIV CALIFORNIA

  公开号：WO2017049016A1

  公开（公告）日：2017-03-23

  A method of altering exocytosis in a plant or animal cell is provided. The method includes exposing the cell to a compound that binds to an EXO70 protein isoform. Also provided is a method of treating diabetes or cancer in a subject in need thereof, which includes administering to the subject an effective amount of a compound that binds to an EXO70 protein isoform. In addition, a method of screening for a substance that alters exocytosis in a plant or animal cell is provided, and analogs of compound Endosidin2 are also provided.

  提供了一种改变植物或动物细胞外排分泌的方法。该方法包括将细胞暴露于结合到EXO70蛋白同工型的化合物中。还提供了一种治疗糖尿病或癌症的方法，包括向需要的受试者施用结合到EXO70蛋白同工型的化合物的有效量。此外，还提供了一种筛选能够改变植物或动物细胞外排分泌的物质的方法，并且还提供了化合物Endosidin2的类似物。
• Komurcu; Rollas; Ulgen, Bollettino Chimico Farmaceutico, 1995, vol. 134, # 7, p. 375 - 379
  作者：Komurcu、Rollas、Ulgen、Gorrod、Cevikbas

  DOI：——

  日期：——
• Patel; dave; Langalia, Journal of the Indian Chemical Society, 1984, vol. 61, # 8, p. 718 - 720
  作者：Patel、dave、Langalia、Thaker

  DOI：——

  日期：——
• THE EXOCYST AS A NOVEL DRUG TARGET OF ENDOSIDIN2 AND APPLICATION AS A THERAPEUTIC
  申请人：The Regents of the University of California

  公开号：US20180362449A1

  公开（公告）日：2018-12-20

  A method of altering exocytosis in a plant or animal cell is provided. The method includes exposing the cell to a compound that binds to an EXO70 protein isoform. Also provided is a method of treating diabetes or cancer in a subject in need thereof which includes administering to the subject an effective amount of a compound that binds to an EXO70 protein isoform. In addition, a method of screening for a substance that alters exocytosis in a plant or animal cell is provided, and analogs of compound Endosidin2 are also provided.