2,5-dioxopyrrolidin-1-yl 2-((((2-(2-nitrophenyl)propoxy)carbonyl)amino)oxy)acetate | 874211-46-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,5-dioxopyrrolidin-1-yl 2-((((2-(2-nitrophenyl)propoxy)carbonyl)amino)oxy)acetate
• 英文别名: (2,5-Dioxopyrrolidin-1-yl) 2-[2-(2-nitrophenyl)propoxycarbonylamino]oxyacetate
• CAS: 874211-46-8
• 化学式: C₁₆H₁₇N₃O₉
• 分子量: 395.326
• InChiKey: UXODUOOIILKDOQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  28
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  157
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  N-羟基丁二酰亚胺 、 2-((((2-(2-nitrophenyl)propoxy)carbonyl)amino)oxy)acetic acid 在 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以100%的产率得到2,5-dioxopyrrolidin-1-yl 2-((((2-(2-nitrophenyl)propoxy)carbonyl)amino)oxy)acetate
  参考文献：
  名称：

  [EN] PHOTOPATTERNED BIOMOLECULE IMMOBILIZATION TO GUIDE 3D CELL FATE IN NATURAL PROTEIN-BASED HYDROGELS
  [FR] IMMOBILISATION DE BIOMOLÉCULES PHOTOMODELÉES POUR GUIDER LE DEVENIR CELLULAIRE 3D DANS DES HYDROGELS À BASE DE PROTÉINE NATURELLE

  摘要：

  Materials, methods, and systems for biorthogonal ligation of hydrogel labels to crosslinked-natural polymer hydrogels are provided. A heterobifunctional linker includes a peptide-reactive activated functional group on the heterobifunctional linker, including an activated amine-reactive functional group, an activated thiol-reactive functional group and being reactive with a hydrogel comprising a crosslinked natural polymer. The heterobifunctional linker also includes a photocaged reactive group including a photocaged hydroxylamine, a photocaged alkoxyamine, a photocaged hydrazide, a photocaged amine, a photocaged tetrazine, or a photocaged alkyne-containing moiety. The peptide-reactive activated functional group does not include an azide.

  公开号：

  WO2022140269A1

文献信息

• AGENTS DE COUPLAGE A GROUPEMENT PROTECTEUR PHOTOLABILE ET LEURS UTILISATIONS, NOTAMMENT POUR LA FONCTIONNALISATION DE SUPPORTS SOLIDES
  申请人：Commissariat à l'énergie atomique et aux énergies alternatives

  公开号：EP1778703B1

  公开（公告）日：2010-06-16
• Coupling Agents Comprising A Photolabile Protecting Group And Uses Thereof, Such As For The Functionalisation Of Solid Supports
  申请人：Hoang Antoine

  公开号：US20070298516A1

  公开（公告）日：2007-12-27

  The invention relates to compounds comprising a photolabile protecting group and to the use thereof as coupling agents for the functionalisation of solid supports. The invention also relates to the solid supports functionalised by said compounds and to the use of same for the immobilisation of biological molecules of interest, such as nucleic acid molecules.
• US7846875B2
  申请人：——

  公开号：US7846875B2

  公开（公告）日：2010-12-07
• [EN] PHOTOPATTERNED BIOMOLECULE IMMOBILIZATION TO GUIDE 3D CELL FATE IN NATURAL PROTEIN-BASED HYDROGELS<br/>[FR] IMMOBILISATION DE BIOMOLÉCULES PHOTOMODELÉES POUR GUIDER LE DEVENIR CELLULAIRE 3D DANS DES HYDROGELS À BASE DE PROTÉINE NATURELLE
  申请人：[en]UNIVERSITY OF WASHINGTON

  公开号：WO2022140269A1

  公开（公告）日：2022-06-30

  Materials, methods, and systems for biorthogonal ligation of hydrogel labels to crosslinked-natural polymer hydrogels are provided. A heterobifunctional linker includes a peptide-reactive activated functional group on the heterobifunctional linker, including an activated amine-reactive functional group, an activated thiol-reactive functional group and being reactive with a hydrogel comprising a crosslinked natural polymer. The heterobifunctional linker also includes a photocaged reactive group including a photocaged hydroxylamine, a photocaged alkoxyamine, a photocaged hydrazide, a photocaged amine, a photocaged tetrazine, or a photocaged alkyne-containing moiety. The peptide-reactive activated functional group does not include an azide.
• Use of γ-aminopropyl-coated glass surface for the patterning of oligonucleotides through oxime bond formation
  作者：Nabil Dendane、Antoine Hoang、Eric Defrancq、Françoise Vinet、Pascal Dumy

  DOI：10.1016/j.bmcl.2008.03.054

  日期：2008.4

  The present work reports on the preparation of glass surfaces coated with NPPOC-protected aminooxy groups and their use for the patterning of oligonucleotides on glass slides and in capillary tubes. The method involves the use of surfaces coated with amino groups using (gamma-aminopropyl)triethoxy silane and subsequent grafting of the aminooxy groups by using the activated ester 1. The NPPOC-protected aminooxy groups on the surfaces can be cleaved upon irradiation. The free aminooxy groups so obtained are subsequently reacted with aldehyde-containing oligonucleotides to achieve efficient surface patterning. (c) 2008 Elsevier Ltd. All rights reserved.