Aethylen-(bis-hydroxy-essigsaeure-amid | 59086-76-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Aethylen-(bis-hydroxy-essigsaeure-amid
• 英文别名: 2-(2-Carbamoylmethoxy-ethoxy)-acetamide；2-[2-(2-amino-2-oxoethoxy)ethoxy]acetamide
• CAS: 59086-76-9
• 化学式: C₆H₁₂N₂O₄
• mdl: MFCD20547522
• 分子量: 176.172
• InChiKey: XEXSGNBDGFXDDF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.2
• 重原子数：
  12
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.666
• 拓扑面积：
  105
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1,2-bis(ethylacetoxy)ethane 在 氨 作用下， 生成 Aethylen-(bis-hydroxy-essigsaeure-amid
  参考文献：
  名称：

  Hesse,G.; Majmudar,S., Chemische Berichte, 1960, vol. 93, p. 1129 - 1137

  摘要：

  DOI：

文献信息

• Ratiometric fluorescent chemosensor for selective detection of Hg (II) ions
  申请人：Chang Suk-Kyu

  公开号：US20080255346A1

  公开（公告）日：2008-10-16

  A mercury selective fluorescent chemosensor for detecting mercury ions (Hg 2+ ) by a compound represented by formula 1 is provided. A novel fluorescent sensitive compound prepared by introducing two aminopyrene functions as a fluorescent sensitive moiety into a binding site of the compound represented by the formula 1, is used for selectively detecting mercury ions (Hg 2+ ) is also provided. The mercury selective fluorescent sensitive chemosensor is a switch type chemosensor having ON-OFF-type Hg 2+ -selective fluorescence quenching behavior and is not affected by other coexistent metal ions. The changes in fluorescence of the compounds represented by formula 1 were analyzed by ratiometric approach using monomer and excimer emissions of the pyrene fluorophore to selectively signal the concentration of mercury ions (Hg 2+ ). The chemosensor can detect mercury ions in a micromolar unit even in a solution including an excess of water. Accordingly, the mercury selective fluorescent chemosensor for detecting mercury ions (Hg 2+ ) can be used effectively in environmental and medical applications.

  提供一种用于检测汞离子（Hg2+）的汞选择性荧光化学传感器，该传感器由代表式1的化合物提供。还提供了一种新型荧光敏感化合物，通过将两个氨基芘功能引入代表式1的化合物的结合位点作为荧光敏感基团，用于选择性检测汞离子（Hg2+）。该汞选择性荧光敏感化学传感器是一种开关型传感器，具有ON-OFF型Hg2+选择性荧光猝灭行为，并不受其他共存金属离子的影响。通过使用芘荧光团的单体和激聚物发射的比率法分析代表式1的化合物的荧光变化，以选择性地信号汞离子（Hg2+）的浓度。该化学传感器可以在包含过量水的溶液中以微摩尔单位检测汞离子。因此，用于检测汞离子（Hg2+）的汞选择性荧光化学传感器可以有效应用于环境和医学领域。
• MEANS FOR THE QUANTITATIVE DETERMINATION OF AN ANALYTE CONCENTRATION IN A PATIENT'S URINE SAMPLE
  申请人：Fuhrmann, Gerda Laura

  公开号：EP3537153A1

  公开（公告）日：2019-09-11

  The present invention relates to a single-use monoanalytical test-strip for the quantitative determination of an analyte in a patient's urine sample, and to a non-invasive point-of-care (POC) device for detecting deficiency and/or overload of an analyte in a patient's body. Furthermore, the present invention relates to a method for quantitatively determining the concentration of an analyte in a patient's urine sample and to a method of detecting deficiency and/or overload of an analyte in a patient's body. The test-strip comprises a substrate which either is electrically insulating or which has an electrically insulating layer applied thereon,- an electrode assembly applied on said substrate or on said electrically insulating layer, if present; and said electrode assembly comprises at least- one analyte-selective working electrode;- one reference electrode for said analyte-selective working electrode and an interface for electrically connecting said electrode assembly to a read out-meter device. Analytes are anions selected from halides, phopshates and sulfates or cations of alkali metals, of alkaline earth metals or of other metals.

  本发明涉及一种用于定量测定患者尿样中分析物的一次性单分析试纸，以及一种用于检测患者体内分析物缺乏和/或过量的非侵入性护理点（POC）设备。此外，本发明还涉及一种定量测定患者尿样中分析物浓度的方法，以及一种检测患者体内分析物缺乏和/或过量的方法。检测条包括一个基板，该基板是电绝缘的，或者在其上涂有电绝缘层；- 一个电极组件，如果有的话，涂在所述基板上或所述电绝缘层上；所述电极组件包括至少--一个分析物选择性工作电极；--一个用于所述分析物选择性工作电极的参比电极，以及一个用于将所述电极组件电连接到读出计装置的接口。分析物为阴离子，选自卤化物、磷酸盐和硫酸盐或碱金属、碱土金属或其他金属的阳离子。
• MEANS FOR THE QUANTITATIVE DETERMINATION OF CATIONIC ELECTROLYTE CONCENTRATION AND CREATININE CONCENTRATION AND OF THEIR RATIOS
  申请人：UriSalt GmbH

  公开号：EP3640633A1

  公开（公告）日：2020-04-22

  The present invention relates to a single-use test strip for the quantitative determination of a concentration of a cationic electrolyte which is not sodium, and of creatinine concentration, and for the subsequent determination of their ratio, and to a non-invasive point-of-care (POC) device for detecting a disorder of electrolyte balance in patient's body. Furthermore, the present invention relates to a method for simultaneously and quantitatively determining a cationic electrolyte concentration and creatinine concentration in a patient's urine sample and to a method of detecting a disorder of electrolyte balance in a patient's body.

  本发明涉及一种一次性试纸，用于定量测定非钠的阳离子电解质浓度和肌酐浓度，以及随后测定它们的比值，还涉及一种用于检测患者体内电解质平衡失调的非侵入性护理点（POC）设备。此外，本发明还涉及一种同时定量测定患者尿样中阳离子电解质浓度和肌酐浓度的方法，以及一种检测患者体内电解质平衡失调的方法。
• Preparations of encapsulated bioavailable chelating agents for detoxifying humans and animals
  申请人：Takemoto C. Arnold

  公开号：US20050208118A1

  公开（公告）日：2005-09-22

  This invention provides, in non-limiting embodiments, novel preparations of chelating agents encapsulated in micelles or liposomes comprising the triple combination of: 1) micelles or liposomes comprising alpha lipoic acid or a derivative thereof and 2) micelles or liposomes comprising a chelating agent, such as EDTA; and furthermore, in different embodiments, optionally 3) magnesium chloride. The micelles or liposomes may be comprised of what have been termed “essential phospholipids”.

  本发明在非限制性实施例中提供了包封在胶束或脂质体中的螯合剂的新型制剂，该制剂包括以下三重组合：1）包含α-硫辛酸或其衍生物的胶束或脂质体；2）包含螯合剂（如 EDTA）的胶束或脂质体；此外，在不同的实施方案中，还可选择 3）氯化镁。胶束或脂质体可由所谓的 "必需磷脂 "组成。
• Encapsulated oral chelating preparations
  申请人：Takemoto C. Arnold

  公开号：US20050208119A1

  公开（公告）日：2005-09-22

  This invention provides, in non-limiting embodiments, novel preparations of chelating agents encapsulated in micelles or liposomes comprising the triple combination of: 1) micelles or liposomes comprising alpha lipoic acid or a derivative thereof and 2) micelles or liposomes comprising a chelating agent, such as EDTA; and furthermore, in different embodiments, optionally 3) magnesium chloride. The micelles or liposomes may be comprised of what have been termed “essential phospholipids”.

  本发明在非限制性实施例中提供了包封在胶束或脂质体中的螯合剂的新型制剂，该制剂包括以下三重组合：1）包含α-硫辛酸或其衍生物的胶束或脂质体；2）包含螯合剂（如 EDTA）的胶束或脂质体；此外，在不同的实施方案中，还可选择 3）氯化镁。胶束或脂质体可由所谓的 "必需磷脂 "组成。