Kobalt(II)-succinat | 3267-76-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Kobalt(II)-succinat
• 英文别名: Cobalt succinate；butanedioate;cobalt(2+)
• CAS: 3267-76-3
• 化学式: C₄H₄O₄*Co
• 分子量: 175.067
• InChiKey: XENHXPKUQLUHCZ-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -2.74
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  80.3
• 氢给体数：
  0
• 氢受体数：
  4

ADMET

代谢

钴通过肺部、胃肠系统和皮肤被吸收。由于它是维生素B12（氰钴胺）的一个组成部分，因此它被分布到身体的大多数组织中。它在血液中运输，通常与白蛋白结合，肝脏和肾脏中的含量最高。钴主要通过尿液和粪便排出。

Cobalt is absorbed though the lungs, gastrointestinal tract, and skin. Since it is a component of the vitamin B12 (cyanocobalamin), it is distributed to most tissues of the body. It is transported in the blood, often bound to albumin, with the highest levels being found in the liver and kidney. Cobalt is excreted mainly in the urine and faeces. (L29)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 毒性总结

识别和使用：醋酸亚钴是一种固体。它用于维生素制剂和治疗剂。人类接触和毒性：无数据可用。动物研究：无数据可用。

IDENTIFICATION AND USE: Cobaltous succinate is a solid. It is used in vitamin preparations and therapeutic agents. HUMAN EXPOSURE AND TOXICITY: There are no data available. ANIMAL STUDIES: There are no data available.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 毒性总结

钴被认为通过氧化剂和自由基过程表现出其毒性。它产生氧自由基，并可能被氧化成离子态的钴，导致脂质过氧化增加、DNA损伤，并诱导某些酶，导致细胞凋亡。钴还被证明可以阻断无机钙通道，可能损害神经传递。钴还可以与硫辛酸螯合，损害丙酮酸或脂肪酸的氧化。此外，钴可能通过与锌指DNA修复蛋白相互作用来抑制DNA修复，并且已被证明可以抑制血红素合成和葡萄糖代谢。钴可能激活特定的辅助性T淋巴细胞，并直接与免疫蛋白（如抗体IgA和IgE或Fc受体）相互作用，导致免疫致敏。（L29）

Cobalt is believed to exhibit its toxicity through a oxidant-based and free radical-based processes. It produces oxygen radicals and may be oxidized to ionic cobalt, causing increased lipid peroxidation, DNA damage, and inducing certain enzymes that lead to cell apoptosis. Cobalt has also been shown to block inorganic calcium channels, possibly impairing neurotransmission. Cobalt can also chelate lipoic acids, impairing oxidation of pyruvate or fatty acids. In addition, cobalt may inhibit DNA repair by interacting with zinc finger DNA repair proteins, and has also been shown to inhibit heme synthesis and glucose metabolism. Cobalt may activate specific helper T-lymphocyte cells and interact directly with immunologic proteins, such as antibodies (IgA and IgE) or Fc receptors, resulting in immunosensitization. (L29)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 致癌性证据

钴和钴化合物在人类中的致癌性证据不足。有充分证据表明钴金属粉末在实验动物中具有致癌性。有限证据显示含有钴、铬和钼的金属合金在实验动物中具有致癌性。总体评估：钴和钴化合物可能对人类具有致癌性（2B组）。

There is inadequate evidence for the carcinogenicity of cobalt and cobalt compounds in humans. There is sufficient evidence for the carcinogenicity of cobalt metal powder in experimental animals. There is limited evidence for the carcinogenicity of metal alloys containing cobalt, chromium and molybdenum in experimental animals. ... Overall Evaluation: Cobalt and cobalt compounds are possibly carcinogenic to humans (Group 2B). /Cobalt and cobalt compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

A3：已确认的动物致癌物，对人类的相关性未知。/钴和钴的无机化合物/

A3: Confirmed animal carcinogen with unknown relevance to humans. /Cobalt and inorganic compounds, as Co/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

钴和释放钴离子的钴化合物根据实验动物研究中充分的致癌性证据以及对致癌机制研究的支持数据，可以合理预期为人类致癌物。/钴和钴化合物/

Cobalt and cobalt compounds that release cobalt ions in vivo are reasonably anticipated to be human carcinogens based on sufficient evidence of carcinogenicity from studies in experimental animals and supporting data from studies on mechanisms of carcinogenesis. /Cobalt and cobalt compounds/

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 海关编码：
  2917190090

反应信息

• 作为反应物：
  描述：

  三异丙醇胺 、 Kobalt(II)-succinat 以 水 为溶剂， 反应 3.0h， 以60%的产率得到[(Co^II)₂(tris(2-hydroxypropyl)amine)₂(succinato)]
  参考文献：
  名称：

  三（2-羟丙基）胺与生物活性羧酸的 NiII、ZnII、CuII 和 CoII 盐的合成和结构

  摘要：

  合成了新的三甲基氢金属特拉烷、三（2-羟丙基）胺配合物与 NiII、ZnII、CuII 和 CoII 盐的生物活性羧酸（苯甲酸、肉桂酸、水杨酸、琥珀酸）。三（2-羟丙基）胺与肉桂酸镍（II）络合物的结构由单晶X射线衍射确定。合成的三(2-羟丙基)胺配合物的热稳定性与三(2-羟乙基)-胺配合物的热稳定性进行了比较。

  DOI：

  10.1007/s11172-020-2855-y
• 作为产物：
  描述：

  丁二酸 生成 Kobalt(II)-succinat
  参考文献：
  名称：

  OCHNEVA V. A.; KONOVA N. M.; DYADCHENKO A. I.; POPOVA Z. G.; PANKOVA T. A+, SINTEZ I ISSLED. EHFFEKTIV. XIMIKATOV DLYA POLIMER. MATER. TEZ. DOKL. K 8+

  摘要：

  DOI：

文献信息

• Synthesis and Equilibrium Studies of Mixed‐Ligand Complexes of Co(II), Ni(II), and Cu(II) with Some Aliphatic Dicarboxylic Acids and Creatinine
  作者：Iman T. Ahmed

  DOI：10.1081/sim-120030438

  日期：2004.3
• ——
  作者：M. A Moustafa、Z. A. Omran、W. A. A. Bayoumy、M. A. Mousa

  DOI：10.1023/a:1010174828300

  日期：——

  The kinetic description and mechanism of the solid-state reactions between metal basic carbonate (M=Co2+, Cu2+ and Zn2+) and aliphatic carboxylic acids (oxalic, tartaric, succinic and citric acids) were studied using non-isothermal analysis (TG, DTA) and capillary techniques. The reactions were found to proceed in all cases (except citric acid) by one mole of metal carbonate and two moles of metal carbonate and two moles of organic acid. The kinetic analyses of non-isothermal data were best described by each of the dimensional phase boundary R-2 and two-dimensional diffusion controlled reactions D-2. While the capillary technique showed that the initial reaction occurs at the phase boundary of the reactants and kinetically of the reacting controlled by diffusion mechanism in which the diffusion species through the product layers are the organic acids.