N-(4-硝基苄基)环戊烷胺 | 70000-59-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-(4-硝基苄基)环戊烷胺
• 英文名称: N-(4-nitrobenzyl)cyclopentanamine
• 英文别名: N-[(4-nitrophenyl)methyl]cyclopentanamine
• CAS: 70000-59-8
• 化学式: C₁₂H₁₆N₂O₂
• mdl: MFCD01134972
• 分子量: 220.271
• InChiKey: SBJOXANGVLVJFT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  57.8
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2921499090

SDS

AKOS B023209MSDS英文版

反应信息

• 作为反应物：
  描述：

  N-(4-硝基苄基)环戊烷胺 在 三乙酰氧基硼氢化钠 、 tin(ll) chloride 作用下， 以 四氢呋喃 、 二氯甲烷 、 水 为溶剂， 反应 5.0h， 生成 3,4-dichloro-N-(4-((cyclopentyl(methyl)amino)methyl)phenyl)benzamide
  参考文献：
  名称：

  Potent and selective CC-chemokine receptor-2 (CCR2) antagonists as a potential treatment for asthma

  摘要：

  A number of compounds bearing a quaternary ammonium moiety were found to be antagonists with nanomolar binding affinity for the chemokine receptor-2. The structure-activity relationships in the series are described herein along with some detailed characterization of the interesting compounds. (c) 2007 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2007.01.115
• 作为产物：
  描述：

  对硝基苯甲醛 、 环戊胺 在 三乙酰氧基硼氢化钠 、 溶剂黄146 作用下， 以 二氯甲烷 为溶剂， 反应 6.0h， 生成 N-(4-硝基苄基)环戊烷胺
  参考文献：
  名称：

  Potent and selective CC-chemokine receptor-2 (CCR2) antagonists as a potential treatment for asthma

  摘要：

  A number of compounds bearing a quaternary ammonium moiety were found to be antagonists with nanomolar binding affinity for the chemokine receptor-2. The structure-activity relationships in the series are described herein along with some detailed characterization of the interesting compounds. (c) 2007 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2007.01.115

文献信息

• Thermal Rearrangement of Sulfamoyl Azides: Reactivity and Mechanistic Study
  作者：Xiaodong Zou、Jiaqi Zou、Lizheng Yang、Guigen Li、Hongjian Lu

  DOI：10.1021/acs.joc.7b00308

  日期：2017.5.5

  The rearrangement of sulfamoyl azides under thermal conditions to form a C–C bond while breaking two C–N bonds is reported. Mechanistic study shows that this reaction goes through a Curtius-type rearrangement to form a 1,1-diazene, then which rearranges possibly through both a concerted rearrangement process and a stepwise radical process. This rearrangement could be used in the synthesis of complex

  据报道，在热条件下，氨磺酰叠氮化物会重排形成一个C–C键，同时打破两个C–N键。机理研究表明，该反应经过库尔修斯式重排形成1，1-二氮杂苯，然后可能通过协同重排过程和逐步自由基过程进行重排。该重排可用于合成复杂的生物活性分子，例如固醇和胡椒碱衍生物。
• Synthesis of γ-lactams via Ru(II)–Pheox-catalyzed regioselective intramolecular Csp3–H insertion of diazoacetamides
  作者：Takuji Fujii、Huong Dang Thi Thu、Seiji Iwasa

  DOI：10.1016/j.tetlet.2020.152276

  日期：2020.9

  Herein, γ-lactam derivatives are obtained in high yield via highly regioselective intramolecular Csp3–H insertion reactions of α-diazoacetamides catalyzed by a rac-Ru(II)–Pheox complex. The catalytic system is applicable to a wide range of diazoacetamides under mild conditions to produce the corresponding γ-lactams.

  在此，以高收率得到γ-内酰胺衍生物通过高度选择性分子内CSP 3通过催化α-diazoacetamides的-H插入反应外消旋-Ru（II）-Pheox复杂。该催化体系可在温和条件下应用于各种重氮乙酰胺，以生产相应的γ-内酰胺。
• Compounds for increasing lipid synthesis and storage
  申请人：NUtech Ventures

  公开号：US10351883B2

  公开（公告）日：2019-07-16

  This invention relates to methods for increasing lipid accumulation and lipid production in cells. Methods of producing biofuel from cells and preparing nutraceuticals comprising lipids produced according to a method provided herein are also provided.

  本发明涉及增加细胞中脂质积累和脂质生产的方法。本发明还提供了从细胞中生产生物燃料的方法，以及制备包含根据本发明提供的方法生产的脂质的营养保健品的方法。
• Compounds for Increasing Lipid Synthesis and Storage
  申请人：NUtech Ventures

  公开号：US20160312253A1

  公开（公告）日：2016-10-27

  This invention relates to methods for increasing lipid accumulation and lipid production in cells. Methods of producing biofuel from cells and preparing nutraceuticals comprising lipids produced according to a method provided herein are also provided.
• Potent and selective CC-chemokine receptor-2 (CCR2) antagonists as a potential treatment for asthma
  作者：Bharat Lagu、Chrissy Gerchak、Meng Pan、Cuifen Hou、Monica Singer、Ravi Malaviya、Michele Matheis、Gil Olini、Druie Cavender、Michael Wachter

  DOI：10.1016/j.bmcl.2007.01.115

  日期：2007.8

  A number of compounds bearing a quaternary ammonium moiety were found to be antagonists with nanomolar binding affinity for the chemokine receptor-2. The structure-activity relationships in the series are described herein along with some detailed characterization of the interesting compounds. (c) 2007 Published by Elsevier Ltd.