N-[2-(1H-benzoimidazol-2-yl)phenyl]-2-morpholin-4-ylacetamide | 312603-80-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: N-[2-(1H-benzoimidazol-2-yl)phenyl]-2-morpholin-4-ylacetamide
• 英文别名: N-[2-(1H-benzimidazol-2-yl)phenyl]-2-morpholin-4-ylacetamide
• CAS: 312603-80-8
• 化学式: C₁₉H₂₀N₄O₂
• 分子量: 336.393
• InChiKey: UUUKZADWUVQLPS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  70.2
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  吗啉 、 N-[2-(1H-benzoimidazol-2-yl)phenyl]-2-chloroacetamide 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以72%的产率得到N-[2-(1H-benzoimidazol-2-yl)phenyl]-2-morpholin-4-ylacetamide
  参考文献：
  名称：

  Synthesis and affinity to DNA of phenylbenzoimidazoles and benzoimidazo[1,2-c]quinazolines

  摘要：

  Novel N-(benzoimidazophenyl)dialkylaminoalkylamides and 6-dialkylaminoalkylbenzojmidazo[1,2-c]quinazolines were prepared as potential interferon inducers and antiviral agents. They were screened for the DNA affinity by the ethidium bromide displacement assay. It was shown that the lg K-a values of the compounds containing tetracyclic benzoimidazo[1,2-c]quinazoline fragment are approximately one order magnitude greater than those of the corresponding acyclic phenylbenzoimidazole derivatives. (C) 2009 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2009.03.004

文献信息

• Synthesis and affinity to DNA of phenylbenzoimidazoles and benzoimidazo[1,2-c]quinazolines
  作者：Elena A. Lyakhova、Yulia A. Gusyeva、Julia V. Nekhoroshkova、Lev M. Shafran、Sergey A. Lyakhov

  DOI：10.1016/j.ejmech.2009.03.004

  日期：2009.8

  Novel N-(benzoimidazophenyl)dialkylaminoalkylamides and 6-dialkylaminoalkylbenzojmidazo[1,2-c]quinazolines were prepared as potential interferon inducers and antiviral agents. They were screened for the DNA affinity by the ethidium bromide displacement assay. It was shown that the lg K-a values of the compounds containing tetracyclic benzoimidazo[1,2-c]quinazoline fragment are approximately one order magnitude greater than those of the corresponding acyclic phenylbenzoimidazole derivatives. (C) 2009 Elsevier Masson SAS. All rights reserved.