trans-3-Methyl-cyclohexan-1-carbonsaeureamid | 13747-97-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: trans-3-Methyl-cyclohexan-1-carbonsaeureamid
• 英文别名: (1R,3R)-3-methylcyclohexane-1-carboxamide
• CAS: 13747-97-2
• 化学式: C₈H₁₅NO
• 分子量: 141.213
• InChiKey: ZHJFHMFTTQIXDF-RNFRBKRXSA-N

物化性质

• 沸点：
  281.9±7.0 °C(Predicted)
• 密度：
  0.974±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-Methylbicyclo<3.1.1>heptan-6-on 在 sodium amide 作用下， 生成 trans-3-Methyl-cyclohexan-1-carbonsaeureamid
  参考文献：
  名称：

  Nerdel,F. et al., Chemische Berichte, 1967, vol. 100, p. 720 - 735

  摘要：

  DOI：

文献信息

• CONDENSED PYRIDINE COMPOUND
  申请人：Astellas Pharma Inc.

  公开号：EP2123651A1

  公开（公告）日：2009-11-25

  The present invention provides a compound having excellent JAK3 inhibitory activity and being useful as an active ingredient of an agent for treating and/or preventing various immune diseases including autoimmune diseases, inflammatory diseases, and allergic diseases. As a result of investigations with respect to novel condensed heterocyclic derivatives, the inventors have verified that a condensed pyridine compound has excellent JAK3 inhibitory activity, thereby completing the present invention. More specifically, it has been verified that since the compound according to the present invention has inhibitory activity against JAK3, the compound is useful as an active ingredient of an agent for treating or preventing diseases caused by undesirable cytokine signal transduction (e.g., rejection during live organ/tissue transplantation, autoimmune diseases, asthma, atopic dermatitis, rheumatism, psoriasis and atherosclerotic disease), or diseases caused by abnormal cytokine signal transduction (e.g., cancer and leukemia).

  本发明提供了一种化合物，该化合物具有优异的 JAK3 抑制活性，可用作治疗和/或预防各种免疫疾病（包括自身免疫性疾病、炎症性疾病和过敏性疾病）的药物的活性成分。 通过对新型缩合杂环衍生物的研究，本发明者验证了一种缩合吡啶化合物具有优异的 JAK3 抑制活性，从而完成了本发明。 更具体地说，由于根据本发明的化合物对 JAK3 具有抑制活性，因此该化合物可用作治疗或预防由不良细胞因子信号转导引起的疾病（如：活体器官/组织过程中的排斥反应）的制剂的活性成分、活体器官/组织移植过程中的排斥反应、自身免疫性疾病、哮喘、特应性皮炎、风湿病、牛皮癣和动脉粥样硬化疾病），或由异常细胞因子信号转导引起的疾病（如癌症和白血病）。
• Process for making neo-enriched p-menthane compounds
  申请人：Renessenz LLC

  公开号：EP2450337A2

  公开（公告）日：2012-05-09

  A process for making neo-enriched p-menthane intermediates is disclosed. Lewis acid-catalyzed rearrangement of an oxaspiro compound provides an aldehyde mixture comprising normal (II) and neo (III) p-menthane-3-aldehydes: with the neo aldehyde (III) as the major product. The aldehyde mixture is readily oxidized to provide the corresponding carboxylic acids, and the acids are easily converted to a host of neo-enriched p-menthane esters or amides. The esters and amides are valuable as physiological coolants.

  本发明公开了一种制造新富集对孟烷中间体的工艺。路易斯酸催化的氧杂螺化合物重排提供了一种醛混合物，其中包括正常 (II) 和新 (III) 对孟烷-3-醛： 新醛 (III) 为主要产物。醛混合物很容易被氧化，生成相应的羧酸，而羧酸又很容易转化为大量新富集的对门烷酯或酰胺。这些酯类和酰胺类化合物是很有价值的生理冷却剂。
• Nerdel,F. et al., Chemische Berichte, 1967, vol. 100, p. 720 - 735
  作者：Nerdel,F. et al.

  DOI：——

  日期：——