3,3'-thiodipropionic acid monododecyl ester | 15968-25-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3,3'-thiodipropionic acid monododecyl ester
• 英文别名: Thiodipropionsaeuremono-n-dodecylester；3-(3-Dodecoxy-3-oxopropyl)sulfanylpropanoic acid
• CAS: 15968-25-9
• 化学式: C₁₈H₃₄O₄S
• 分子量: 346.532
• InChiKey: XDILCINHTMZTGG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  23
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  88.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  重氮甲烷 、 3,3'-thiodipropionic acid monododecyl ester 以 乙醚 为溶剂， 生成 methyl dodecyl 3,3'-thiodipropionate
  参考文献：
  名称：

  Dialkyl 3,3‘-Thiodipropionate and Dialkyl 2,2‘-Thiodiacetate Antioxidants by Lipase-Catalyzed Esterification and Transesterification

  摘要：

  Medium- and long-chain dialkyl 3,3'-thiodipropionate antioxiclants such as dioctyl 3,3'-thiodipropionate, didodecyl 3,3'-thiodipropionate, clihexadecyl 3,3'-thiodipropionate, and di-(cis-9-octadecenyl) 3,3'-thiodipropionate were prepared in high yield by lipase-catalyzed esterification and transesterification of 3,3'-thiodipropionic acid and its dimethyl ester, respectively, with the corresponding medium- or long-chain 1-alkanols, i.e., 1-octanol, 1-dodecanol, 1-hexadecanol, and cis-9-octadecen-1-ol, in vacuo (80 kPa) at moderate temperatures (60-80 degrees C) without solvents. Immobilized lipase B from Candida antarctica (Novozym 435) was the most active biocatalyst for the preparation of medium- and longchain dialkyl 3,3'-thiodipropionates showing enzyme activities up to 1489 units/g, whereas the immobilized lipases from Phizomucor miehei (Lipozyme RM IM) and Thermomyces lanuginosus (Lipozyme TL IM) were by far less active (similar to 10 enzyme units/g). Maximum conversions to dialkyl 3,3'-thiodipropionates were as high as 92-98% after 4 h of reaction time. Similarly, dihexadecyl 2,2'-thiodiacetate was prepared in high yield using 2,2'-thiodiacetic acid or diethyl 2,2'-thiodiacetate and 1-hexaclecanol as the starting materials and Novozym 435 as the biocatalyst.

  DOI：

  10.1021/jf0530502
• 作为产物：
  描述：

  硫代二丙酸 、 十二烷醇 在 硫酸 作用下， 以 叔丁醇 为溶剂， 生成 3,3'-thiodipropionic acid monododecyl ester
  参考文献：
  名称：

  Dialkyl 3,3‘-Thiodipropionate and Dialkyl 2,2‘-Thiodiacetate Antioxidants by Lipase-Catalyzed Esterification and Transesterification

  摘要：

  Medium- and long-chain dialkyl 3,3'-thiodipropionate antioxiclants such as dioctyl 3,3'-thiodipropionate, didodecyl 3,3'-thiodipropionate, clihexadecyl 3,3'-thiodipropionate, and di-(cis-9-octadecenyl) 3,3'-thiodipropionate were prepared in high yield by lipase-catalyzed esterification and transesterification of 3,3'-thiodipropionic acid and its dimethyl ester, respectively, with the corresponding medium- or long-chain 1-alkanols, i.e., 1-octanol, 1-dodecanol, 1-hexadecanol, and cis-9-octadecen-1-ol, in vacuo (80 kPa) at moderate temperatures (60-80 degrees C) without solvents. Immobilized lipase B from Candida antarctica (Novozym 435) was the most active biocatalyst for the preparation of medium- and longchain dialkyl 3,3'-thiodipropionates showing enzyme activities up to 1489 units/g, whereas the immobilized lipases from Phizomucor miehei (Lipozyme RM IM) and Thermomyces lanuginosus (Lipozyme TL IM) were by far less active (similar to 10 enzyme units/g). Maximum conversions to dialkyl 3,3'-thiodipropionates were as high as 92-98% after 4 h of reaction time. Similarly, dihexadecyl 2,2'-thiodiacetate was prepared in high yield using 2,2'-thiodiacetic acid or diethyl 2,2'-thiodiacetate and 1-hexaclecanol as the starting materials and Novozym 435 as the biocatalyst.

  DOI：

  10.1021/jf0530502

文献信息

• [EN] CYCLOHEXENE DERIVATIVES AS FRAGRANCES AND/OR FLAVORS<br/>[FR] DÉRIVÉS DE CYCLOHEXÈNE COMME FRAGRANCES ET/OU ARÔMES
  申请人：SYMRISE AG

  公开号：WO2017133754A1

  公开（公告）日：2017-08-10

  The present invention relates to novel cyclohexene derivatives selected from the group consisting of formula (la) and/or (lb), and the use of the cyclohexene derivatives and their isomers as fragrances, especially as fragrances with a rhubarb odour tonality, and fragrance and/or flavouring compositions as well as consumer products, comprising the cyclohexene derivatives of formula (la) and/or (lb).

  本发明涉及从化学式（Ia）和/或（Ib）所述的新型环己烯衍生物中选择的环己烯衍生物，以及将环己烯衍生物及其异构体用作香料，特别是具有大黄气味音调的香料，以及包含化学式（Ia）和/或（Ib）所述的环己烯衍生物的香料和/或调味剂组合物以及消费产品。
• 2-Hydroxy-4-alkoxy-5-aminomethylbenzophenones and their use as photostabilisers in polymeric compositions, a process for preparing a 5,5-methylene bis (2-hydroxy-4-alkoxybenzophenone).
  申请人：S.A. Diamond Shamrock Benelux N.V.

  公开号：EP0006091A1

  公开（公告）日：1980-01-09

  2-Hydroxy-4-alkoxy-5-aminomethylbenzophenones of formula: in which R is an alkyl group having 1 to 12 carbon atoms, and R, and R2 taken together form a 5 to 6 member heterocyclic ring free of carbonyl substituents and including the nitrogen atom, or are independent hydrogen atoms or alkyl groups having 1 to 6 carbon atoms, provided that R, and R2 are not simultaneously hydrogen, are described. They are prepared by reaction of a 2-hydroxy-4-alkoxy-5-amino- methylbenzophenone with an amine and formaldehyde. The compounds can be used, alone or in combination with other stabilisers, to prevent photodegradation of organic materials, particularly as light stabilisers for synthetic resins. 5,5-methylene bis(2-hydroxy-4-alkoxy-benzophenone) of formula: wherein R ist an alkyl group having 1 to 12 carbon atoms is prepared by condensation of a 2-hydroxy-4-alkoxy-5-aminomethylbenzophenone with itself or with a 2-hydroxy-4-alkoxybenzophenone. This compounds also are useful to prevent photodegradation of organic materials, particulary as stabilisers for synthetic resins.

  式中的 2-羟基-4-烷氧基-5-氨基甲基二苯甲酮： 其中 R 是具有 1 至 12 个碳原子的烷基，R 和 R2 共同形成一个不含羰基取代基并包括氮原子的 5 至 6 个成员的杂环，或者是独立的氢原子或具有 1 至 6 个碳原子的烷基，但 R 和 R2 不能同时为氢。它们是通过 2-羟基-4-烷氧基-5-氨基-甲基二苯甲酮与胺和甲醛反应制备的。这些化合物可单独使用，也可与其他稳定剂结合使用，以防止有机材料的光降解，特别是用作合成树脂的光稳定剂。 式中的 5,5-亚甲基双（2-羟基-4-烷氧基二苯甲酮）： 其中 Rt 是具有 1 至 12 个碳原子的烷基，由 2-羟基-4-烷氧基-5-氨基甲基二苯甲酮与自身或 2-羟基-4-烷氧基二苯甲酮缩合而成。这种化合物还可用于防止有机材料的光降解，特别是用作合成树脂的稳定剂。
• Stabilized polymers and their production and stabilizers therefor
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0079806A1

  公开（公告）日：1983-05-25

  A heat, light and oxidation stabilizer for polymers such as synthetic rubbers and resins comprises (a) at least one sulfur-containing compound of the general formula: wherein R, represents an alkyl group having 4 to 20 carbon atoms and (b) at least one phenolic compound of the general formula: wherein the Rz's are selected from alkyl groups having 1 to 4 carbon atoms, the weight ratio of (a) : (b) being from 1 : 0.1 to 1 : 2. The stabilizer ingredients may be added separately or together to the polymer or to monomer or prepolymer therefor. Preferred stabilizer ingredients are (a) pentaerythritol-tetrakis(β-dodecyl thiopropionate) and/or (b) 2-(2-hydroxy-3-t-butyl-5-methylbenzyl)-4-methyl-6-t-butylphenyl acrylate.

  用于合成橡胶和树脂等聚合物的热、光和氧化稳定剂包括 (a) 至少一种通式如下的含硫化合物 其中 R 代表具有 4 至 20 个碳原子的烷基和 (b) 至少一种通式如下的酚类化合物 其中 Rz 选自具有 1 至 4 个碳原子的烷基，(a) : (b) 的重量比为 1 : 0.1 至 1 : 2。稳定剂成分可单独或一起添加到聚合物或其单体或预聚物中。首选的稳定剂成分是 (a) 季戊四醇-四(β-十二烷基硫代丙酸酯)和/或 (b) 2-(2-羟基-3-叔丁基-5-甲基苄基)-4-甲基-6-叔丁基苯基丙烯酸酯。
• Process for the preparation of N-substituted maleimides
  申请人：Tosoh Corporation

  公开号：EP0393713A1

  公开（公告）日：1990-10-24

  N-substituted maleimide represented by formula (2): is produced from N-substituted maleamic acid monoester represented by formula (1): in the presence of an acid catalyst by elimination of an alcohol from the monoester. The above N-substituted maleamic acid monoester represented by formula (1) is produced by esterification of N-substituted maleamic acid represented by formula (3): with an alcohol R² -OH in the presence of an acid catalyst.

  以式（2）代表的 N-取代马来酰亚胺： 由式（1）代表的 N-取代马来酰亚胺酸单酯在酸催化剂存在下，通过消除单酯中的醇而制得： 在酸催化剂存在下，通过消除单酯中的醇而制得。上述由式（1）代表的 N-取代马来酰胺酸单酯类由由式（3）代表的 N-取代马来酰胺酸与醇 R² -OH 在酸催化剂存在下进行酯化反应制得： 与醇 R² -OH 在酸催化剂存在下进行酯化反应制得。
• Water-disposable tampon applicators and biodegradable composition for use therein
  申请人：National Starch and Chemical Investment Holding Corporation

  公开号：EP0438672A1

  公开（公告）日：1991-07-31

  This invention provides biodegradable tampon applicators adapted for disposal in water-base toilet systems. This invention also provides plasticized starch compositions for use in the fabrication of tampon applicators and methods for fabrication thereof.

  本发明提供适用于水基厕所系统处理的可生物降解卫生棉条涂抹器。本发明还提供了用于制造卫生棉条涂抹器的塑化淀粉组合物及其制造方法。