2-[2-Nitro-1-(2-nitrophenyl)ethyl]cyclopentan-1-one | 1253423-97-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[2-Nitro-1-(2-nitrophenyl)ethyl]cyclopentan-1-one
• 英文别名: 2-[2-nitro-1-(2-nitrophenyl)ethyl]cyclopentan-1-one
• CAS: 1253423-97-0
• 化学式: C₁₃H₁₄N₂O₅
• 分子量: 278.265
• InChiKey: AYEZYHDORRQFKV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  109
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-[2-Nitro-1-(2-nitrophenyl)ethyl]cyclopentan-1-one 在 铁粉 作用下， 以 溶剂黄146 为溶剂， 反应 2.0h， 以83%的产率得到2,3-二氢-1H-环戊并[b]喹啉
  参考文献：
  名称：

  Iron/acetic acid-mediated carbon degradation: a facile route for the synthesis of quinoline derivatives

  摘要：

  A new carbon degradation protocol which results in the formation of quinoline derivatives is described. The reactions involved the use of mild reaction conditions and an inexpensive reducing reagent (Fe/AcOH). (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.07.063
• 作为产物：
  描述：

  1-nitro-2-(2-nitrovinyl)benzene 、 环戊酮 在 C₂₉H₃₉N₃O₃S 、 苯甲酸 作用下， 反应 12.0h， 以90%的产率得到
  参考文献：
  名称：

  Michael reaction of ketones and β-nitrostyrenes catalyzed by camphor-10-sulfonamide-based prolinamide

  摘要：

  Novel camphor sulfonamide based organocatalysts were evaluated for their catalytic activity in the Michael reaction of ketones with nitroolefins Reaction of ketones with beta-nitrostyrenes in the presence of 20 mol % organocatalyst 1a and benzoic acid under solvent-free conditions at 0 degrees C provided the desired Michael adducts with high chemical yields (up to 97%) and excellent stereoselectivines (>99 1) (C) 2010 Elsevier Ltd All rights reserved

  DOI：

  10.1016/j.tetasy.2010.09.012

文献信息

• Iron/acetic acid-mediated carbon degradation: a facile route for the synthesis of quinoline derivatives
  作者：Chintakunta Ramesh、Veerababurao Kavala、Chun-Wei Kuo、Ching-Fa Yao

  DOI：10.1016/j.tetlet.2010.07.063

  日期：2010.10

  A new carbon degradation protocol which results in the formation of quinoline derivatives is described. The reactions involved the use of mild reaction conditions and an inexpensive reducing reagent (Fe/AcOH). (C) 2010 Elsevier Ltd. All rights reserved.
• Michael reaction of ketones and β-nitrostyrenes catalyzed by camphor-10-sulfonamide-based prolinamide
  作者：Rashmi Rani、Rama Krishna Peddinti

  DOI：10.1016/j.tetasy.2010.09.012

  日期：2010.10

  Novel camphor sulfonamide based organocatalysts were evaluated for their catalytic activity in the Michael reaction of ketones with nitroolefins Reaction of ketones with beta-nitrostyrenes in the presence of 20 mol % organocatalyst 1a and benzoic acid under solvent-free conditions at 0 degrees C provided the desired Michael adducts with high chemical yields (up to 97%) and excellent stereoselectivines (>99 1) (C) 2010 Elsevier Ltd All rights reserved