N-(9H-芴-2-基)苯甲酰胺 | 3671-78-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 中文名称: N-(9H-芴-2-基)苯甲酰胺
• 英文名称: N-2-fluorenylbenzamide
• 英文别名: 2-Benzoylaminofluorene；N-(9H-fluoren-2-yl)benzamide
• CAS: 3671-78-1
• 化学式: C₂₀H₁₅NO
• 分子量: 285.345
• InChiKey: MEZOSXXWXWNPDU-UHFFFAOYSA-N

物化性质

• 熔点：
  215 °C
• 沸点：
  427.77°C (rough estimate)
• 密度：
  1.1281 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2924299090

反应信息

• 作为反应物：
  描述：

  N-(9H-芴-2-基)苯甲酰胺 在 水 、 sodium methylate 、 碳酸氢钠 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 2.5h， 生成 N-(4a-hydroxy-9a-methoxy-9H-fluoren-2-yl)benzamide
  参考文献：
  名称：

  Preparation of quinol N-acyl- and quinol ether imines via anodic oxidation of para-substituted anilide derivatives

  摘要：

  Anodic oxidation of N-benzoyl-4-methylaniline in 5 % aqueous methanol in the presence of sodium bicarbonate affords two major products: 4-methoxy-4-methylbenzoquinol N-benzoylimine, 8a, and a dimer, 4-[N-benzoyl-N-(4-methylphenyl)amino]-4-methylbenzoquinol N-benzoylimine, 9. The ratio of these two products was temperature dependent, and conditions were developed for preparing 8a and 9 in good yield. Using the conditions developed for 8a, the anodic methoxylation of N-benzoyl and acetyl derivatives of 4-ethyl- and 4-sec-butyl-4-phenylaniline and 2-aminofluorene derivatives was performed. The yields of the N-benzoyl derivatives of the 4-methoxy-4-substituted-benzoquinol imines were 46-80%, while the N-acetyl derivatives gave lower yields. When the anodic oxidation was performed using 30% water/acetonitrile or 10 % water/tetrahydrofuran, the 4-alkylbenzoquinol N-benzoylimine derivatives were obtained. The yields of these anodic hydroxylation reactions were lower than those of the corresponding methoxylations for all systems studied. In addition, the 4-alkylbenzoquinol N-benzoylimine derivatives were much more labile. Two methods were developed for conversion of the 4-methoxy-4-substituted-benzoquinol N-acylimines to the 4-methoxy-4-substituted-benzoquinol N-alkylimines. Finally, the especially labile 4-hydroxy-4-phenylbenzoquinol N-acetylimine was prepared for the first time from the readily available N-benzoyl derivative.

  DOI：

  10.1021/jo00073a016
• 作为产物：
  描述：

  2-氨基芴 以80%的产率得到
  参考文献：
  名称：

  FARCASAN, V.;PAIU, F.;OLTEANU, I.;DEMIAN, H., STUD. UNIV. BABES-BOLYAI. CHEM., 1985, 30, 5-10

  摘要：

  DOI：

文献信息

• Chromium-Catalyzed Activation of Acyl C–O Bonds with Magnesium for Amidation of Esters with Nitroarenes
  作者：Liang Ling、Changpeng Chen、Meiming Luo、Xiaoming Zeng

  DOI：10.1021/acs.orglett.9b00554

  日期：2019.3.15

  chromium-catalyzed activation of acyl C–O bonds with magnesium for amidation of esters with nitroarenes. Low-cost chromium(III) chloride shows high reactivity in promoting amidation by using magnesium as reductant and chlorotrimethylsilane as additive. It provides a step-economic strategy to the synthesis of centrally important amide motifs using inexpensive and air-stable nitroarenes as amino sources.

  在这里，我们报道了铬与镁催化的羰基C–O键活化，从而使酯与硝基芳烃酰胺化。通过使用镁作为还原剂和氯代三甲基硅烷作为添加剂，低成本的氯化铬（III）在促进酰胺化方面显示出高反应活性。它为使用廉价且空气稳定的硝基芳烃作为氨基源合成重要的酰胺基序提供了分步经济策略。
• [EN] BAX AGONIST, COMPOSITIONS, AND METHODS RELATED THERETO<br/>[FR] AGONISTE DE BAX, COMPOSITIONS ET PROCÉDÉS ASSOCIÉS
  申请人：UNIV EMORY

  公开号：WO2013028543A1

  公开（公告）日：2013-02-28

  The disclosure relates to BAX activators and therapeutic uses relates thereto. In certain embodiments, the disclosure relates to methods of treating or preventing cancer, such as lung cancer, comprising administering a therapeutically effective amount of a pharmaceutical composition comprising a compound disclosed herein or pharmaceutically acceptable salt to a subject in need thereof.

  本公开涉及BAX激活剂及其治疗用途。在某些实施例中，本公开涉及治疗或预防癌症的方法，例如肺癌，包括向需要的受试者施用本公开的化合物或药学上可接受的盐所述的药物组合的治疗有效量。
• COMPOSITIONS AND METHODS FOR TREATMENT OF VIRAL DISEASES
  申请人：Johansen Lisa M.

  公开号：US20100009970A1

  公开（公告）日：2010-01-14

  The present invention features compositions, methods, and kits useful in the treatment of viral diseases. In certain embodiments, the viral disease is caused by a single stranded RNA virus, a flaviviridae virus, or a hepatic virus. In particular embodiments, the viral disease is viral hepatitis (e.g., hepatitis A, hepatitis B, hepatitis C, hepatitis D, hepatitis E) and the agent or combination of agents includes sertraline, a sertraline analog, UK-416244, or a UK-416244 analog. Also featured are screening methods for identification of novel compounds that may be used to treat a viral disease.

  本发明涉及用于治疗病毒性疾病的组合物、方法和试剂盒。在某些实施方式中，病毒性疾病是由单链RNA病毒、黄病毒科病毒或肝病毒引起的。在特定实施方式中，病毒性疾病是病毒性肝炎（例如甲型肝炎、乙型肝炎、丙型肝炎、丁型肝炎、戊型肝炎），药剂或药剂组合包括舍曲林、舍曲林类似物、UK-416244或UK-416244类似物。还包括用于鉴定可用于治疗病毒性疾病的新化合物的筛选方法。
• BAX AGONIST, COMPOSITIONS, AND METHODS RELATED THERETO
  申请人：Deng Xingming

  公开号：US20140178374A1

  公开（公告）日：2014-06-26

  The disclosure relates to BAX activators and therapeutic uses relates thereto. In certain embodiments, the disclosure relates to methods of treating or preventing cancer, such as lung cancer, comprising administering a therapeutically effective amount of a pharmaceutical composition comprising a compound disclosed herein or pharmaceutically acceptable salt to a subject in need thereof.

  该披露涉及BAX活化剂及其治疗用途。在某些实施例中，该披露涉及治疗或预防癌症的方法，例如肺癌，包括向需要该治疗的受试者施用含有此处披露的化合物或药学上可接受的盐的药物组合物的治疗有效量。
• THE RELATIVE PROPORTIONS OF STEREOISOMERIC OXIMES FORMED IN THE OXIMATION OF UNSYMMETRICAL KETONES
  作者：W. E. BACHMANN、SISTER M. XAVERIA BARTON

  DOI：10.1021/jo01221a003

  日期：1938.9