N-([1,3]噻唑并[5,4-b]吡啶-2-基)苯甲酰胺 | 742640-87-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-([1,3]噻唑并[5,4-b]吡啶-2-基)苯甲酰胺
• 中文别名: (9CI)-N-噻唑并[5,4-B]吡啶-2-基-苯甲酰胺
• 英文名称: N-thiazolo[5,4-b]pyridin-2-yl-benzamide
• 英文别名: N-([1,3]thiazolo[5,4-b]pyridin-2-yl)benzamide
• CAS: 742640-87-5
• 化学式: C₁₃H₉N₃OS
• 分子量: 255.3
• InChiKey: YBHRSXBMLOWBLL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  83.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-([1,3]噻唑并[5,4-b]吡啶-2-基)苯甲酰胺 在 硫酸 、 水 作用下， 以56%的产率得到噻唑并[5,4-B]2-氨基吡啶
  参考文献：
  名称：

  A New Method for Synthesizing Asymmetric Urea Containing Thiazolo[5,4-b]pyridine And Applications in Agriculture

  摘要：

  In this article, we describe the use of diphenyl carbonate (DPC) as a carbonyl source instead of isocyanate to synthesize asymmetric substituted urea derivatives. In a study aiming to discover new lead compounds with agricultural activities, thiazole[5,4-b]pyridine ureas were prepared by this method and characterized by mass spectrometry, elemental analysis, and H-1 NMR spectroscopy. The biological activities show that the title compounds have moderate activities on herbicide, fungicide, and plant growth regulation.

  DOI：

  10.1080/10426507.2010.497518
• 作为产物：
  描述：

  N-benzoyl-N'-(2-chloro-3-pyridyl)thiourea 在 sodium methylate 作用下， 以 N-甲基吡咯烷酮 为溶剂， 反应 8.0h， 以75%的产率得到N-([1,3]噻唑并[5,4-b]吡啶-2-基)苯甲酰胺
  参考文献：
  名称：

  A New Method for Synthesizing Asymmetric Urea Containing Thiazolo[5,4-b]pyridine And Applications in Agriculture

  摘要：

  In this article, we describe the use of diphenyl carbonate (DPC) as a carbonyl source instead of isocyanate to synthesize asymmetric substituted urea derivatives. In a study aiming to discover new lead compounds with agricultural activities, thiazole[5,4-b]pyridine ureas were prepared by this method and characterized by mass spectrometry, elemental analysis, and H-1 NMR spectroscopy. The biological activities show that the title compounds have moderate activities on herbicide, fungicide, and plant growth regulation.

  DOI：

  10.1080/10426507.2010.497518

文献信息

• Arya,V.P. et al., Indian Journal of Chemistry, 1973, vol. 11, p. 744 - 746
  作者：Arya,V.P. et al.

  DOI：——

  日期：——
• A New Method for Synthesizing Asymmetric Urea Containing Thiazolo[5,4-b]pyridine And Applications in Agriculture
  作者：Wenbin Chen、Kejian Li

  DOI：10.1080/10426507.2010.497518

  日期：2011.1.31

  In this article, we describe the use of diphenyl carbonate (DPC) as a carbonyl source instead of isocyanate to synthesize asymmetric substituted urea derivatives. In a study aiming to discover new lead compounds with agricultural activities, thiazole[5,4-b]pyridine ureas were prepared by this method and characterized by mass spectrometry, elemental analysis, and H-1 NMR spectroscopy. The biological activities show that the title compounds have moderate activities on herbicide, fungicide, and plant growth regulation.