7-azido-5-methyl-3-phenylthiazolo<4,5-d>pyrimidin-2(3H)-thione | 151993-56-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 7-azido-5-methyl-3-phenylthiazolo<4,5-d>pyrimidin-2(3H)-thione
• 英文别名: 7-Azido-5-methyl-3-phenyl-thiazolo[4,5-d]pyrimidine-2-thione；7-azido-5-methyl-3-phenyl-[1,3]thiazolo[4,5-d]pyrimidine-2-thione
• CAS: 151993-56-5
• 化学式: C₁₂H₈N₆S₂
• 分子量: 300.368
• InChiKey: IFRBIGZCLDCKHQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  101
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  7-azido-5-methyl-3-phenylthiazolo<4,5-d>pyrimidin-2(3H)-thione 在 sodium dithionite 作用下， 以 乙醇 、 水 为溶剂， 反应 1.0h， 以60%的产率得到7-amino-5-methyl-3-phenylthiazolo<4,5-d>pyrimidin-2(3H)-thione
  参考文献：
  名称：

  Potential anti-microbials. II. Synthesis and in vitro anti-microbial evaluation of some thiazolo[4,5-d]pyrimidines

  摘要：

  Some thiazolo[4,5-d]pyrimidines were prepared in order to investigate their antimicrobial activity. A significant inhibitory effect was recorded for many compounds against Staphylococcus aureus ATCC 25923 (3, 6, 9a; MIC = 10-20 mug/ml), Escherichia coli ATCC 25922 (3,5,9b, MIC = 40 mug/ml) and Candida albicans DSM 70443 (6, MIC = 50 mug/ml).

  DOI：

  10.1016/0223-5234(93)90002-v
• 作为产物：
  描述：

  7-chloro-5-methyl-3-phenylthiazolo<4,5-d>pyrimidin-2(3H)-thione 在 sodium azide 作用下， 以 丙酮 为溶剂， 反应 1.0h， 以80%的产率得到7-azido-5-methyl-3-phenylthiazolo<4,5-d>pyrimidin-2(3H)-thione
  参考文献：
  名称：

  Potential anti-microbials. II. Synthesis and in vitro anti-microbial evaluation of some thiazolo[4,5-d]pyrimidines

  摘要：

  Some thiazolo[4,5-d]pyrimidines were prepared in order to investigate their antimicrobial activity. A significant inhibitory effect was recorded for many compounds against Staphylococcus aureus ATCC 25923 (3, 6, 9a; MIC = 10-20 mug/ml), Escherichia coli ATCC 25922 (3,5,9b, MIC = 40 mug/ml) and Candida albicans DSM 70443 (6, MIC = 50 mug/ml).

  DOI：

  10.1016/0223-5234(93)90002-v

文献信息

• Potential anti-microbials. II. Synthesis and in vitro anti-microbial evaluation of some thiazolo[4,5-d]pyrimidines
  作者：ESAM Badawey、SM Rida、AA Hazza、HTY Fahmy、YM Gohar

  DOI：10.1016/0223-5234(93)90002-v

  日期：1993.1

  Some thiazolo[4,5-d]pyrimidines were prepared in order to investigate their antimicrobial activity. A significant inhibitory effect was recorded for many compounds against Staphylococcus aureus ATCC 25923 (3, 6, 9a; MIC = 10-20 mug/ml), Escherichia coli ATCC 25922 (3,5,9b, MIC = 40 mug/ml) and Candida albicans DSM 70443 (6, MIC = 50 mug/ml).