N-Tosyl-tyrosin | 6297-78-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-Tosyl-tyrosin
• 英文别名: N-p-toluenesulfonyltyrosine；3-(4-hydroxyphenyl)-2-[(4-methylphenyl)sulfonylamino]propanoic acid
• CAS: 6297-78-5
• 化学式: C₁₆H₁₇NO₅S
• 分子量: 335.381
• InChiKey: SQNOPFKSXJGLQI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  112
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  N-Tosyl-tyrosin 在 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 为溶剂， 反应 32.0h， 生成 N-[3-(4-hydroxyphenyl)-1-[(4E)-4-[1-(4-nitrophenyl)-5-oxopyrrolidin-2-ylidene]-3,5-dioxo-2-phenylpyrazolidin-1-yl]-1-oxopropan-2-yl]-4-methylbenzenesulfonamide
  参考文献：
  名称：

  Abou El Ela, Ahmed; Donia, Shafie G., Polish Journal of Chemistry, 1988, vol. 62, # 4-6, p. 465 - 472

  摘要：

  DOI：

文献信息

• PARA-QUINOL DERIVATIVES AND METHODS OF STEREO SELECTIVELY SYNTHESIZING AND USING SAME
  申请人：Plourde Guy L.

  公开号：US20090318548A1

  公开（公告）日：2009-12-24

  This application relates to para-quinol derivatives, such as analogues of manumycins, aranorosins and gymnastatins. This application also relates to methods of synthesizing and using the para-quinol derivatives. In one embodiment of the invention a compound having the chemical structure (I) is provided wherein X 1 and X 2 are carbon atoms either joined by double bond or joined by a single bond and comprising constituents of an epoxide ring or a hydroxyethylene moiety; X 3 and X 4 are carbon atoms either joined by double bond or joined by a single bond and comprising constituents of an epoxide ring; R 1 is selected from the group consisting of branched alkyl chains, unbranched alkyl chains, cycloalkyl groups, aromatic groups, alcohols, ethers, amines, and substituted or unsubstituted ureas, esters, aldehydes and carboxylic acids; and R 2 is selected from the group consisting of H, OH and NHR 3 wherein R 3 is a nitrogen protecting group. In a particular embodiment of the invention R 1 is a polyunsaturated carbon chain as found in biologically active manumycins. The applicant's synthetic method may involve diasteroselective formation of a spirolactone in an oxidative spiroannulation process using tyrosine or a tyrosine derivative having a chiral centre as a starting material.

  本申请涉及对位喹啉衍生物，例如曼纽霉素、阿拉诺罗辛和体操霉素的类似物。本申请还涉及合成和使用对位喹啉衍生物的方法。在发明的一个实施例中，提供了具有化学结构（I）的化合物，其中X1和X2是由双键连接或单键连接的碳原子，并包括环氧环或羟基乙烯基的组分；X3和X4是由双键连接或单键连接的碳原子，并包括环氧环的组分；R1选自支链烷基链，直链烷基链，环烷基团，芳香族团，醇，醚，胺和取代或未取代的脲、酯、醛和羧酸；R2选自H，OH和NHR3，其中R3是氮保护基。在发明的一个特定实施例中，R1是生物活性曼纽霉素中发现的多不饱和碳链。申请人的合成方法可能涉及使用酪氨酸或手性中心的酪氨酸衍生物作为起始材料，在氧化螺环化过程中二面体选择性地形成螺内酯。
• ABOU, EL ELA AHMED;DONIA, SHAFIE G., POL. J. CHEM., 62,(1988) N-6, C. 465-471
  作者：ABOU, EL ELA AHMED、DONIA, SHAFIE G.

  DOI：——

  日期：——
• TANNING PREPARATION FOR THE SKIN
  申请人：Dija Zeist B.V.

  公开号：EP1255531A1

  公开（公告）日：2002-11-13
• [EN] TANNING PREPARATION FOR THE SKIN<br/>[FR] PREPARATION DE BRONZAGE DE LA PEAU
  申请人：DIJA ZEIST BV

  公开号：WO2001060330A1

  公开（公告）日：2001-08-23

  The invention relates to a tanning preparation for the skin comprising at least one tyrosine derivative of formula 1, where R1 = -H, -(CH¿2?)x-CH3, x being an integer from 1 to 20, R?2 = CH¿3CO-, CH3-(CH2)yCO-, y being an integer from 1 to 20, and an activator consisting of an aliphatic polyol having at least 10 C atoms in the molecule. The aliphatic polyol preferably consists of a hexadecanetriol, in particular phytantriol. Expediently, the tanning preparation is a gel, lotion, cream, foam, spray or emulsion. The invention further relates to a controlled release tanning preparation for the skin.
• [EN] MULTI-PURPOSE AUTOMATED RADIOTRACER SYNTHESIZER<br/>[FR] DISPOSITIF DE SYNTHESE DE MARQUEURS RADIOACTIFS AUTOMATISE MULTIFONCTION
  申请人：UNIV TEXAS

  公开号：WO2005057589A2

  公开（公告）日：2005-06-23

  Systems and methods are described for synthesizing oil soluble and water soluble agents. The system may include, for example, an isotope preparation unit to produce cyclotron-based isotopes, generator-based isotopes, and/or single dose isotopes. A flow unit including at least one valve assembly controls the flow of the isotopes as well as reagents needed to form the radiotracers. A synthesizer unit is configured to synthesize both oil soluble and water soluble agents and generate the radiotracers.