N,O-dimethylacryloylhydroxylamine | 138693-15-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N,O-dimethylacryloylhydroxylamine
• 英文别名: MANHOMA；N,0-dimethylacryloylhydroxylamine；N,O-dimethacryloyl hydroxylamine；N,O-dimethacryloylhydroxylamine；(2-methylprop-2-enoylamino) 2-methylprop-2-enoate
• CAS: 138693-15-9
• 化学式: C₈H₁₁NO₃
• 分子量: 169.18
• InChiKey: BKJSUTPZEULXEB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N,O-dimethylacryloylhydroxylamine 生成 N-(2-羟基丙基)甲基丙烯酰胺
  参考文献：
  名称：

  Hydrolytically degradable hydrophilic gels and the method for

  摘要：

  该解决方案涉及由含有结构单元##STR1##的交联物相互连接的亲水性高分子单体链组成的水解降解性亲水性凝胶。制备水解降解凝胶的方法包括在新化合物N，O-二甲基丙烯酰羟胺作为交联剂的情况下，将亲水性单体或其混合物与自由基聚合或共聚合，或与疏水性单体共聚合，如果需要，可以在溶剂的存在下进行，而亲水性单体的量相对于所有单体的量为50至99.8摩尔百分比。

  公开号：

  US05130479A1
• 作为产物：
  描述：

  甲基丙烯酰氯 在 吡啶 、 盐酸羟胺 作用下， 以 氯仿 为溶剂， 反应 2.67h， 生成 N,O-dimethylacryloylhydroxylamine
  参考文献：
  名称：

  Biodegradable stealth polymeric particles fabricated using the macromonomer approach by free radical dispersion polymerization

  摘要：

  本发明涉及交联或非交联聚合物颗粒，其中交联聚合物颗粒包括至少一种可水解单体交联的聚（烷基乙二醇-嫁接-乳酸酯）共聚物。本发明的另一实施例是一种聚合物颗粒，包括由起始材料（a）一种亲水单体，（b）一种疏水单体和（c）一种可水解交联剂组成的交联聚合物颗粒。本发明的另一实施例是一种聚合物颗粒，包括由式（I）、（II）和（III）所表示的结构组成的交联共聚物，其中式（I）、（II）和（III）在说明书中定义。本发明的其他实施例还包括制备甲基丙烯酸酯末端的大分子单体的方法、制备交联剂的方法以及通过分散聚合制备治疗剂载药纳米球的方法。

  公开号：

  US08921429B2

文献信息

• HYDROLYSABLE LINKERS AND CROSS-LINKERS FOR ABSORBABLE POLYMERS
  申请人：Bezwada Rao S.

  公开号：US20090082540A1

  公开（公告）日：2009-03-26

  The present invention relates to the discovery of new class of linear and multiarmed hydrolysable linkers and cross linkers for use in the synthesis of biodegradable polymers such as, polyesters, polyurethanes, polyamides, polyureas and degradable epoxy amine resin. The linear and multiarmed hydrolysable linkers of the present invention include symmetrical and/or unsymmetrical ether carboxylic acids, amines, amide diols, amine polyols and isocyanates.

  本发明涉及一种新型线性和多臂可水解连接剂和交联剂的发现，用于合成可生物降解聚合物，如聚酯、聚氨酯、聚酰胺、聚脲和可降解环氧胺树脂。本发明的线性和多臂可水解连接剂包括对称和/或非对称的醚羧酸、胺、酰胺二醇、胺多元醇和异氰酸。
• THERMORESPONSIVE, BIODEGRADABLE, ELASTOMERIC MATERIAL
  申请人：Guan Jianjun

  公开号：US20080096975A1

  公开（公告）日：2008-04-24

  Provided are novel biocompatible copolymers and compositions comprising the copolymers. The copolymers and degradation products thereof are non-toxic and typically have an LCST between room temperature and 37° C. so that they are liquid at room temperature and gelled at 37° C. which facilitates their use in humans, for example for wound treatment and as a cellular growth matrix or niche. The copolymer comprises numerous ester linkages in its backbone so that the copolymers are erodeable in situ. Degradation products of the polymer are soluble and non-toxic. The copolymer is amine-reactive so that it can conjugate with proteins, such as collagen. Active ingredients, such as drugs, can be incorporated into compositions comprising the copolymer.

  提供了一种新型的生物相容性共聚物和包含该共聚物的组合物。该共聚物及其降解产物无毒，并通常具有在室温和37℃之间的LCST，因此它们在室温下是液态，在37℃时是凝胶状的，有助于它们在人体内的应用，例如用于创伤治疗以及作为细胞生长基质或环境。该共聚物的骨架中包含众多的酯键，因此它们可以在原位被侵蚀。聚合物的降解产物可溶性且无毒。该共聚物具有胺反应性，因此可以与蛋白质（如胶原蛋白）结合。包含该共聚物的组合物中可以加入活性成分，如药物。
• BIODEGRADABLE STEALTH POLYMERIC PARTICLES FABRICATED USING THE MACROMONOMER APPROACH BY FREE RADICAL DISPERSION POLYMERIZATION
  申请人：AKALA Emmanuel

  公开号：US20120129797A1

  公开（公告）日：2012-05-24

  The present invention is directed to a crosslinked or non-crosslinked polymer particle, wherein the crosslinked polymer particle comprises a copolymer of poly(alklyene glycol-graft-lactate) that is crosslinked by at least one hydrolysable monmer. Another embodiment of the present invention is a polymer particle comprising a crosslinked polymer particle that is a product of starting materials comprising (a) a hydrophilic monomer, (b) a hydrophobic monomer, and (c) a hydrolysable crosslinking agent. Another embodiment of the present invention is a polymer particle comprising, a crosslinked copolymer comprises structures represented by Formulas (I), (II), and (III), where Formulas (I), (II) and (III) are defined in the specification. Yet other embodiments of the present invention include a method of preparing a methacrylate terminated macromonomer, a method of preparing a crosslinking agent, and a method of preparing a therapeutic agent loaded nanosphere by dispersion polymerization.

  本发明涉及交联或非交联聚合物颗粒，其中交联聚合物颗粒包括聚（烷基二醇接枝乳酸酯）共聚物，该共聚物由至少一种可水解单体交联。本发明的另一实施例是聚合物颗粒，包括由起始材料制成的交联聚合物颗粒，该起始材料包括（a）亲水性单体，（b）疏水性单体和（c）可水解交联剂。本发明的另一实施例是聚合物颗粒，包括交联共聚物，其结构由式（I）、（II）和（III）表示，其中式（I）、（II）和（III）在说明书中有定义。本发明的其他实施例包括制备甲基丙烯酸酯末端的大分子单体的方法，制备交联剂的方法以及通过分散聚合制备治疗剂载药纳米球的方法。
• STEALTH POLYMERIC PARTICLES FOR DELIVERY OF BIOACTIVE OR DIAGNOSTIC AGENTS
  申请人：AKALA Emmanuel

  公开号：US20120129798A1

  公开（公告）日：2012-05-24

  The present invention is directed to a crosslinked or non-crosslinked polymer particle, wherein the crosslinked polymer particle comprises a copolymer of poly(alklyene glycol-graft-acrylate) that is crosslinked by at least one hydrolysable monomer or crosslinking agent. The present invention is also directed to a polymer particle comprising a crosslinked polymer particle that is a product of starting materials comprising (a) a hydrophilic monomer, (b) a hydrophobic monomer, and (c) a hydrolysable crosslinking agent (the crosslinking agent may be absent in the case of non-crosslinked particles). The present invention is still further directed to a polymer particle comprising a crosslinked copolymer, where the crosslinked copolymer includes structures represented by Formulas (I), (II), and (III), as defined in the specification. Other embodiments of the present invention also include methods of manufacturing polymer particles.

  本发明涉及交联或非交联聚合物颗粒，其中交联聚合物颗粒包括至少一种可水解单体或交联剂交联的聚（烷基乙二醇接枝丙烯酸酯）共聚物。本发明还涉及一种聚合物颗粒，其包括起始材料的产物，该起始材料包括（a）亲水性单体，（b）疏水性单体和（c）可水解交联剂（在非交联颗粒的情况下，交联剂可以不存在）的交联聚合物颗粒。本发明还涉及一种聚合物颗粒，其包括交联共聚物，其中交联共聚物包括由规范中定义的公式（I）、（II）和（III）表示的结构。本发明的其他实施方式还包括制造聚合物颗粒的方法。
• Compositions and methods for delivery of kinase inhibiting peptides
  申请人：PURDUE RESEARCH FOUNDATION

  公开号：US10034839B2

  公开（公告）日：2018-07-31

  The invention relates to compositions and methods for the treatment of inflammatory disease states. In particular, the invention relates to the use of a nanoparticle incorporated kinase inhibiting peptide to treat inflammatory disease states.

  本发明涉及治疗炎症性疾病状态的组合物和方法。特别是，本发明涉及使用掺入激酶抑制肽的纳米颗粒来治疗炎症性疾病。