4-ethyl-4-hydroxy-N-[12-(2-methylprop-2-enoylamino)dodecyl]hexanamide | 1239895-99-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 4-ethyl-4-hydroxy-N-[12-(2-methylprop-2-enoylamino)dodecyl]hexanamide
• CAS: 1239895-99-8
• 化学式: C₂₄H₄₆N₂O₃
• 分子量: 410.641
• InChiKey: NODRETUDOCVSDY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  29
• 可旋转键数：
  19
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  78.4
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-ethyl-4-hydroxy-N-[12-(2-methylprop-2-enoylamino)dodecyl]hexanamide 、 diisopropylsilanediyl bistriflate 在 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 生成
  参考文献：
  名称：

  Scalable Synthetic Oligodeoxynucleotide Purification with Use of a Catching by Polymerization, Washing, and Releasing Approach

  摘要：

  Synthetic oligodeoxynucleotides are purified with use of a catching by polymerization, washing, and releasing approach. The method does not require any chromatography, and purification is achieved by simple operations such as shaking, washing, and extraction. It is therefore useful for large-scale purification of synthetic oligonucleotide drugs. In addition to purification of oligonucleotides, this catching by polymerization concept is expected to be equally useful for purification of other synthetic oligomers such as peptides and oligosaccharides.

  DOI：

  10.1021/ol101316g
• 作为产物：
  描述：

  N-(12-aminododecyl)-4-hydroxy-4-ethylhexanamide 、 甲基丙烯酰氯 在 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 以86%的产率得到4-ethyl-4-hydroxy-N-[12-(2-methylprop-2-enoylamino)dodecyl]hexanamide
  参考文献：
  名称：

  Scalable Synthetic Oligodeoxynucleotide Purification with Use of a Catching by Polymerization, Washing, and Releasing Approach

  摘要：

  Synthetic oligodeoxynucleotides are purified with use of a catching by polymerization, washing, and releasing approach. The method does not require any chromatography, and purification is achieved by simple operations such as shaking, washing, and extraction. It is therefore useful for large-scale purification of synthetic oligonucleotide drugs. In addition to purification of oligonucleotides, this catching by polymerization concept is expected to be equally useful for purification of other synthetic oligomers such as peptides and oligosaccharides.

  DOI：

  10.1021/ol101316g

文献信息

• PURIFICATION OF SYNTHETIC OLIGONUCLEOTIDES
  申请人：Fang Shiyue

  公开号：US20130211065A1

  公开（公告）日：2013-08-15

  This invention provides a method for purifying synthetic oligonucleotides comprising capping, polymerizing and separating any failure sequences produced during oligonucleotide synthesis. The invention also provides a method for purifying synthetic oligonucleotides comprising reacting a full length oligonucleotide with a compound to attach a polymerizable functional group to an end of the full length oligonucleotide, polymerizing the full length oligonucleotides and removing the failure sequences, and recovering the full length oligonucleotides. The invention also provides novel capping agents having a polymerizable functional group, and kits comprising at least one composition of the present invention.

  本发明提供了一种纯化合成寡核苷酸的方法，包括在寡核苷酸合成过程中进行帽子化、聚合和分离任何产生的失败序列。本发明还提供了一种纯化合成寡核苷酸的方法，包括将完整长度的寡核苷酸与化合物反应，将可聚合的功能基团附加到完整长度的寡核苷酸末端，聚合完整长度的寡核苷酸并去除失败序列，最后回收完整长度的寡核苷酸。本发明还提供了具有可聚合功能基团的新型帽子试剂，以及包含本发明至少一种组分的试剂盒。
• US9243023B2
  申请人：——

  公开号：US9243023B2

  公开（公告）日：2016-01-26
• Scalable Synthetic Oligodeoxynucleotide Purification with Use of a Catching by Polymerization, Washing, and Releasing Approach
  作者：Shiyue Fang、Suntara Fueangfung

  DOI：10.1021/ol101316g

  日期：2010.8.20

  Synthetic oligodeoxynucleotides are purified with use of a catching by polymerization, washing, and releasing approach. The method does not require any chromatography, and purification is achieved by simple operations such as shaking, washing, and extraction. It is therefore useful for large-scale purification of synthetic oligonucleotide drugs. In addition to purification of oligonucleotides, this catching by polymerization concept is expected to be equally useful for purification of other synthetic oligomers such as peptides and oligosaccharides.