(E)-N-methoxy-N-methyl-2-(2-[prop-1-en-1-yl]phenoxy)acetamide | 1448663-01-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (E)-N-methoxy-N-methyl-2-(2-[prop-1-en-1-yl]phenoxy)acetamide
• 英文别名: N-methoxy-N-methyl-2-(2-[(1E)-prop-1-en-1-yl]phenoxy)acetamide；N-methoxy-N-methyl-2-[2-[(E)-prop-1-enyl]phenoxy]acetamide
• CAS: 1448663-01-1
• 化学式: C₁₃H₁₇NO₃
• 分子量: 235.283
• InChiKey: QDPPZHLNAXSQMF-QPJJXVBHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-氯-正甲氧基-正甲基乙酰胺 、 2-丙烯基苯酚 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 20.25h， 以66.667%的产率得到
  参考文献：
  名称：

  Efficient, durable and reusable olefin metathesis catalysts with high affinity to silica gel

  摘要：

  The new Scorpio type olefin metathesis catalysts with very high affinity to silica gel are reported. After completion of the reaction, those complexes can be efficiently separated from reaction product by direct filtration of reaction mixture through a short pad of silica gel. Products obtained by this methodology are contaminated with low amounts of residual ruthenium. Especially, catalyst (H2IPr)(Cl)(2)Ru=C(H)(C6H4OR) (5b, R=CH(Me)(C(O)N(Me)OMe) exhibited very high activity and could be easily recovered and reused. Additionally, this catalyst was found to be effective already at 0.1-0.5 mol % and showed good compatibility with environmentally benign solvents. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.06.056

文献信息

• Metal Complexes, Their Application and Methods of Carrying out of Metathesis Reaction
  申请人：Apeiron Synthesis S.A.

  公开号：US20150126744A1

  公开（公告）日：2015-05-07

  This disclosure relates to new metal complexes, such as compounds of Formula 1, and their application in olefin or alkyne metathesis and to methods of carrying out olefin metathesis reactions.
• US8933242B2
  申请人：——

  公开号：US8933242B2

  公开（公告）日：2015-01-13
• US9527877B2
  申请人：——

  公开号：US9527877B2

  公开（公告）日：2016-12-27
• Efficient, durable and reusable olefin metathesis catalysts with high affinity to silica gel
  作者：Krzysztof Skowerski、Piotr Kasprzycki、Michał Bieniek、Tomasz K. Olszewski

  DOI：10.1016/j.tet.2013.06.056

  日期：2013.9

  The new Scorpio type olefin metathesis catalysts with very high affinity to silica gel are reported. After completion of the reaction, those complexes can be efficiently separated from reaction product by direct filtration of reaction mixture through a short pad of silica gel. Products obtained by this methodology are contaminated with low amounts of residual ruthenium. Especially, catalyst (H2IPr)(Cl)(2)Ru=C(H)(C6H4OR) (5b, R=CH(Me)(C(O)N(Me)OMe) exhibited very high activity and could be easily recovered and reused. Additionally, this catalyst was found to be effective already at 0.1-0.5 mol % and showed good compatibility with environmentally benign solvents. (C) 2013 Elsevier Ltd. All rights reserved.