Bis-(2-hydroxy-ethyl)-carbamic acid 2-{2-[bis-(2-hydroxy-ethyl)-carbamoyloxy]-ethoxy}-ethyl ester | 252378-64-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Bis-(2-hydroxy-ethyl)-carbamic acid 2-{2-[bis-(2-hydroxy-ethyl)-carbamoyloxy]-ethoxy}-ethyl ester
• 英文别名: 2-[2-[bis(2-hydroxyethyl)carbamoyloxy]ethoxy]ethyl N,N-bis(2-hydroxyethyl)carbamate
• CAS: 252378-64-6
• 化学式: C₁₄H₂₈N₂O₉
• 分子量: 368.384
• InChiKey: YJFSWSYPPMPTMU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.9
• 重原子数：
  25
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  149
• 氢给体数：
  4
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  Bis-(2-hydroxy-ethyl)-carbamic acid 2-{2-[bis-(2-hydroxy-ethyl)-carbamoyloxy]-ethoxy}-ethyl ester 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 25.0h， 生成 Bis-(2-hydroxy-ethyl)-carbamic acid 2-({2-[2-(bis-{2-[bis-(2-hydroxy-ethyl)-carbamoyloxy]-ethyl}-carbamoyloxy)-ethoxy]-ethoxycarbonyl}-{2-[bis-(2-hydroxy-ethyl)-carbamoyloxy]-ethyl}-amino)-ethyl ester
  参考文献：
  名称：

  Synthesis of multivalent carbonate esters by divergent growth of branched carbamates

  摘要：

  Multivalent 4-nitrophenyl (PNP)-carbonate esters were prepared from carbonate ester-containing core groups by a new divergent-growth process. The process doubles the number of PNP-carbonate esters with each round of growth, or branching, which occurs by reacting an N,N-dihydroxylalkyl amine with a PNP-carbonate ester. The resulting N,N-dihydroxyalkyl carbamate contains two hydroxyl groups for each original PNP-carbonate ester. The hydroxyl groups are converted in situ to PNP-carbonate esters, and the process can be repeated to provide successive generations of dendrimer-like branched structures of increased valence. (C) 2001 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(01)00078-8
• 作为产物：
  描述：

  二乙醇胺 、 Bis(4-nitrophenyl) (oxybis(ethane-2,1-diyl)) bis(carbonate) 在 吡啶 作用下， 反应 5.0h， 生成 Bis-(2-hydroxy-ethyl)-carbamic acid 2-{2-[bis-(2-hydroxy-ethyl)-carbamoyloxy]-ethoxy}-ethyl ester
  参考文献：
  名称：

  Synthesis of multivalent carbonate esters by divergent growth of branched carbamates

  摘要：

  Multivalent 4-nitrophenyl (PNP)-carbonate esters were prepared from carbonate ester-containing core groups by a new divergent-growth process. The process doubles the number of PNP-carbonate esters with each round of growth, or branching, which occurs by reacting an N,N-dihydroxylalkyl amine with a PNP-carbonate ester. The resulting N,N-dihydroxyalkyl carbamate contains two hydroxyl groups for each original PNP-carbonate ester. The hydroxyl groups are converted in situ to PNP-carbonate esters, and the process can be repeated to provide successive generations of dendrimer-like branched structures of increased valence. (C) 2001 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(01)00078-8

文献信息

• Chemically-defined non-polymeric valency platform molecules and conjugates thereof
  申请人：Coutts M. Stephen

  公开号：US20070254851A1

  公开（公告）日：2007-11-01

  Chemically-defined, non-polymeric valency platform molecules and conjugates comprising chemically-defined valency platform molecules and biological or chemical molecules including polynucleotide duplexes of at least 20 base pairs that have significant binding activity for human lupus anti-dsDNA autoantibodies.

  化学定义的非聚合价平台分子和共轭物，包括化学定义的价平台分子和生物或化学分子，其中包括至少具有20个碱基对的多核苷酸双链，对人类狼疮抗dsDNA自身抗体具有显著的结合活性。
• CHEMICALLY-DEFINED NON-POLYMERIC VALENCY PLATFORM MOLECULES AND CONJUGATES THEREOF
  申请人：COUTTS Stephen M.

  公开号：US20080293660A1

  公开（公告）日：2008-11-27

  Chemically-defined, non-polymeric valency platform molecules and conjugates comprising chemically-defined valency platform molecules and biological or chemical molecules including polynucleotide duplexes of at least 20 base pairs that have significant binding activity for human lupus anti-dsDNA autoantibodies.

  化学定义的、非聚合物的价态平台分子和共轭物，包括化学定义的价态平台分子和生物或化学分子，其中包括至少具有20个碱基对的多核苷酸双链，对人类狼疮抗dsDNA自身抗体具有显著的结合活性。
• Hydroxy functional alkyl carbamate crosslinkers
  申请人：PPG Industries Ohio, Inc.

  公开号：US11053191B2

  公开（公告）日：2021-07-06

  A hydroxy functional alkyl carbamate is disclosed having the formula: wherein R comprises a substituted or unsubstituted C1 to C36 alkyl group, an aromatic group, and/or a polymeric moiety; wherein each R1 is independently a hydrogen, alkyl having at least 1 carbon, or a hydroxy functional alkyl having 2 or more carbons and at least one R1 is a hydroxy functional alkyl having 2 or more carbons; and n is 2-6. The present invention is also directed to a composition, and substrates coated therewith, comprising a film-forming resin; and a hydroxy functional alkyl carbamate crosslinker having the formula shown above. Other hydroxy functional alkyl carbamate compounds, polymers made with the same, and compositions comprising the same are also disclosed as are substrates coated at least in part with or formed with any of the compositions described herein.

  所公开的羟基官能烷基氨基甲酸酯具有以下式子： 其中 R 包括取代或未取代的 C1 至 C36 烷基、芳香族基团和/或聚合分子；其中每个 R1 独立地为氢、具有至少 1 个碳的烷基或具有 2 个或更多碳的羟基官能团烷基，且至少一个 R1 为具有 2 个或更多碳的羟基官能团烷基；以及 n 为 2-6。 本发明还涉及一种组合物及其涂覆的基材，该组合物包含成膜树脂；以及具有上式的羟基官能烷基氨基甲酸酯交联剂。 本发明还公开了其他羟基官能团氨基甲酸烷基酯化合物、用其制成的聚合物和包含其的组合物，以及至少部分涂覆或用本文所述任何组合物形成的基材。
• HYDROXY FUNCTIONAL ALKYL CARBAMATE CROSSLINKERS
  申请人：PPG Industries Ohio, Inc.

  公开号：US20190210962A1

  公开（公告）日：2019-07-11

  A hydroxy functional alkyl carbamate is disclosed having the formula: wherein R comprises a substituted or unsubstituted C 1 to C 36 alkyl group, an aromatic group, and/or a polymeric moiety; wherein each R 1 is independently a hydrogen, alkyl having at least 1 carbon, or a hydroxy functional alkyl having 2 or more carbons and at least one R 1 is a hydroxy functional alkyl having 2 or more carbons; and n is 2-6. The present invention is also directed to a composition, and substrates coated therewith, comprising a film-forming resin; and a hydroxy functional alkyl carbamate crosslinker having the formula shown above. Other hydroxy functional alkyl carbamate compounds, polymers made with the same, and compositions comprising the same are also disclosed as are substrates coated at least in part with or formed with any of the compositions described herein.
• US7351855B2
  申请人：——

  公开号：US7351855B2

  公开（公告）日：2008-04-01