N-(氨基甲基)苯甲酰胺 | 67908-02-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-(氨基甲基)苯甲酰胺
• 英文名称: N-(aminomethyl)benzamide
• 英文别名: N-(Benzamidomethyl)-amin；N-Aminomethyl-benzamid
• CAS: 67908-02-5
• 化学式: C₈H₁₀N₂O
• 分子量: 150.18
• InChiKey: OMDXVUUWBNVTTO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4,5-辛二酮 、 N-(氨基甲基)苯甲酰胺 在 溶剂黄146 作用下， 反应 4.0h， 生成
  参考文献：
  名称：

  A new synthesis of unsubstituted, 4(5),and 4,5-substituted 1H-imidazoles.

  摘要：

  DOI：

  10.1016/s0040-4039(00)85122-9
• 作为产物：
  描述：

  N-苯甲酰基甘氨酸甲酯 在 alkaline aqueous potassium hypobromite solution 、 氨 作用下， 生成 N-(氨基甲基)苯甲酰胺
  参考文献：
  名称：

  Kanewskaja, Chemische Berichte, 1936, vol. 69, p. 266,270

  摘要：

  DOI：

文献信息

• Method of treating cancer
  申请人：Rosen Neal

  公开号：US20050137207A1

  公开（公告）日：2005-06-23

  The present invention relates to methods of treating cancer using a combination of a compound which is an antineoplastic agent and a compound which is a inhibitor of prenyl-protein transferase, which methods comprise administering to said mammal, either sequentially in any order or simultaneously, amounts of at least two therapeutic agents selected from a group consisting of a compound which is an antineoplastic agent and a compound which is a inhibitor of prenyl-protein transferase. The invention also relates to methods of preparing such compositions.

  本发明涉及使用一种抗肿瘤剂和一种前尼蛋白转移酶抑制剂的组合治疗癌症的方法，该方法包括向所述哺乳动物施用来自以下组中至少两种治疗剂的量，所述组包括一种抗肿瘤剂和一种前尼蛋白转移酶抑制剂，所述治疗剂可以按任何顺序依次或同时施用。该发明还涉及制备这种组合物的方法。
• [EN] APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS<br/>[FR] INHIBITEURS DE KINASE 1 DE RÉGULATION DE SIGNAL D'APOPTOSE
  申请人：TAKEDA PHARMACEUTICAL

  公开号：WO2009123986A1

  公开（公告）日：2009-10-08

  The present invention relates to apoptosis signal-regulating kinase 1 ("ASK1") inhibiting compounds of the formula (I); wherein the variables are as defined herein. The invention also relates to pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

  本发明涉及具有以下结构的凋亡信号调节激酶1（"ASK1"）抑制化合物（I）；其中变量如本文所定义。该发明还涉及包含这些化合物的药物组合物、试剂盒和制造品；用于制备这些化合物的有用中间体和方法；以及使用这些化合物的方法。
• [EN] INHIBITORS OF THE MICROSOMAL PROSTAGLANDIN E2 SYNTHASE-1<br/>[FR] INHIBITEURS DE LA PROSTAGLANDINE E2 SYNTHASE-1 MICROSOMALE
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2011048004A1

  公开（公告）日：2011-04-28

  This invention relates to compounds of formula I, their use as inhibitors of the microsomal prostaglandin E2 synthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of inflammatory diseases and associated conditions such as inflammatory/nociceptive pain. A, M, R1, R2, R7' Ra, Rb, Q3, Q4, Q6, Z2, Z4, Z5, Z6 and W have meanings given in the description.

  本发明涉及公式I的化合物，其用作微粒体前列腺素E2合酶-1（mPGES-1）的抑制剂，含有这些化合物的药物组合物，以及它们作为治疗和/或预防炎症性疾病及相关症状（如炎症性/疼痛性疼痛）的药物的用途。A、M、R1、R2、R7'、Ra、Rb、Q3、Q4、Q6、Z2、Z4、Z5、Z6和W在说明中有定义。
• Ionic Liquids for Separation of Olefin-Paraffin Mixtures
  申请人：Dai Sheng

  公开号：US20110015461A1

  公开（公告）日：2011-01-20

  The invention is directed to an ionic liquid comprising (i) a cationic portion containing a complex of a silver (I) ion and one or more neutral ligands selected from organoamides, organoamines, olefins, and organonitriles, and (ii) an anionic portion having the chemical formula wherein m and n are independently 0 or an integer of 1 or above, and p is 0 or 1, provided that when p is 0, the group —N—SO 2 —(CF 2 ) n CF 3 subtended by p is replaced with an oxide atom connected to the shown sulfur atom. The invention is also directed to a method for separating an olefin from an olefin-paraffin mixture by passing the mixture through a layer of the ionic liquid described above.

  该发明涉及一种离子液体，包括（i）含有银（I）离子的阳离子部分，该离子与来自有机酰胺、有机胺、烯烃和有机腈中选择的一个或多个中性配体形成的络合物，以及（ii）具有化学式的阴离子部分，其中m和n独立地为0或大于1的整数，p为0或1，但当p为0时，由p支撑的基团—N—SO2—(CF2)nCF3将被连接到所示硫原子的氧原子替代。该发明还涉及一种从烯烃烷烃混合物中分离烯烃的方法，通过将混合物经过上述离子液体的一层来实现。
• [EN] PRODUCTION PROCESS OF AMINOMETHYL GROUP-CONTAINING BENZAMIDE COMPOUND<br/>[FR] PROCEDE DE PRODUCTION D'UN COMPOSE DE BENZAMIDE CONTENANT UN GROUPE AMINOMETHYLE
  申请人：SHOWA DENKO KK

  公开号：WO2003097579A1

  公开（公告）日：2003-11-27

  ABSTRACT There is provided a process for producing an aminomethyl group-containing benzamide compound represented by the general formula (II):wherein -CONH2 and -X represent a substituent on the benzene ring and -CONH2 exists at the meta- or para-position of -CH2NH2, and X and n are as defined below, which comprises hydrating an aminomethyl group-containing benzonitrile compound represented by the general formula (I):wherein -CN and -X represent a substituent on the benzene ring and -CN exists at the meta- or para-position of -CH2NH2, X represents a chlorine atom or a fluorine atom, and n represents an integer of 0 to 4, provided that, when n is 2 or more, X may be the same or different.

  摘要：提供了一种制备含氨甲基基团苯甲酰胺化合物的方法，该化合物由通式（II）表示，其中-CONH2和-X表示苯环上的取代基，-CONH2存在于-CH2NH2的间位或邻位，X和n如下所定义，包括水合化含氨甲基基团苯腈化合物的步骤，该化合物由通式（I）表示，其中-CN和-X表示苯环上的取代基，-CN存在于-CH2NH2的间位或邻位，X表示氯原子或氟原子，n表示0到4的整数，当n为2或更多时，X可以相同或不同。