1-(10-ethyl-5,6,7,8-tetrahydro-[2]phenanthryl)-2-bromo-ethanone | 6321-61-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: 1-(10-ethyl-5,6,7,8-tetrahydro-[2]phenanthryl)-2-bromo-ethanone
• 英文别名: 1-(10-Aethyl-5,6,7,8-tetrahydro-[2]phenanthryl)-2-brom-aethanon；NSC30820；2-Bromo-1-(10-ethyl-5,6,7,8-tetrahydrophenanthren-2-yl)ethanone
• CAS: 6321-61-5
• 化学式: C₁₈H₁₉BrO
• 分子量: 331.252
• InChiKey: RPZCQYBKVFZDLR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 乙醚 、 溴 作用下， 生成 1-(10-ethyl-5,6,7,8-tetrahydro-[2]phenanthryl)-2-bromo-ethanone
  参考文献：
  名称：

  1,2,3,4-四氢菲与衍生物的反应; 烷基衍生物和抗疟疾药物。

  摘要：

  DOI：

  10.1021/jo01168a017

文献信息

• COMPOSITIONS AND METHODS FOR INHIBITING G PROTEIN SIGNALING
  申请人：Smrcka Alan V.

  公开号：US20090221691A1

  公开（公告）日：2009-09-03

  The present invention relates to methods for identifying agents which bind to specific amino acid residues of the protein interaction site of G protein β protein subunit. Compounds identified in accordance with the assay of the invention and methods for using the compound for modulating at least one activity of a G protein are also provide.
• Compositions and Methods for Inhibiting G Protein Signaling
  申请人：University of Rochester

  公开号：US20130116313A1

  公开（公告）日：2013-05-09

  The present invention relates to methods for identifying agents which bind to specific amino acid residues of the protein interaction site of G protein β protein subunit. Compounds identified in accordance with the assay of the invention and methods for using the compound for modulating at least one activity of a G protein are also provided.
• US8748480B2
  申请人：——

  公开号：US8748480B2

  公开（公告）日：2014-06-10
• US8975259B2
  申请人：——

  公开号：US8975259B2

  公开（公告）日：2015-03-10
• REACTIONS OF 1,2,3,4-TETRAHYDROPHENANTHRENE AND DERIVATIVES. III. ALKYL DERIVATIVES AND ANTIMALARIALS
  作者：W. E. BACHMANN、M. W. CRONYN、W. S. STRUVE

  DOI：10.1021/jo01168a017

  日期：1947.7