3-benzyl-2-(4-(2-(methyl(pyridin-2-yl)amino)ethoxy)phenyl)thiazolidin-4-one sulfone | 1334242-07-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3-benzyl-2-(4-(2-(methyl(pyridin-2-yl)amino)ethoxy)phenyl)thiazolidin-4-one sulfone
• 英文别名: 3-Benzyl-2-[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]-1,1-dioxo-1,3-thiazolidin-4-one；3-benzyl-2-[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]-1,1-dioxo-1,3-thiazolidin-4-one
• CAS: 1334242-07-7
• 化学式: C₂₄H₂₅N₃O₄S
• 分子量: 451.546
• InChiKey: RLLGPACPHJJJSU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  32
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  88.2
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  3-benzyl-2-(4-(2-(methyl(pyridin-2-yl)amino)ethoxy)phenyl)thiazolidin-4-one sulfoxide 在 Oxone 作用下， 以 甲醇 、 水 为溶剂， 以63.3%的产率得到3-benzyl-2-(4-(2-(methyl(pyridin-2-yl)amino)ethoxy)phenyl)thiazolidin-4-one sulfone
  参考文献：
  名称：

  Thiazolidin-4-one and thiazinan-4-one derivatives analogous to rosiglitazone as potential antihyperglycemic and antidyslipidemic agents

  摘要：

  A number of thiazolidin-4-one and thiazinan-4-one derivatives were prepared by three component condensation in one pot reaction method. These compounds were evaluated for anti-hyperglycemic activity by in vitro and in vivo assay systems. The compounds with thiazolidin-4-one and thiazinan-4-one moieties exhibited significant anti-hyperglycemic activity. A few compounds (3a, 3b, 4a and 4b) have exhibited both anti-hyperglycemic and anti-dyslipidemic activities. Among them the thiazinan-4-one derivative 4a showed maximal (45%) improvement in oral glucose tolerance test in db/db mice at 30 mg/kg oral dose. (C) 2013 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2013.01.054

文献信息

• Thiazolidin-4-one and thiazinan-4-one derivatives analogous to rosiglitazone as potential antihyperglycemic and antidyslipidemic agents
  作者：Saman Raza、Swayam P. Srivastava、Daya S. Srivastava、Arvind K. Srivastava、W. Haq、S.B. Katti

  DOI：10.1016/j.ejmech.2013.01.054

  日期：2013.5

  A number of thiazolidin-4-one and thiazinan-4-one derivatives were prepared by three component condensation in one pot reaction method. These compounds were evaluated for anti-hyperglycemic activity by in vitro and in vivo assay systems. The compounds with thiazolidin-4-one and thiazinan-4-one moieties exhibited significant anti-hyperglycemic activity. A few compounds (3a, 3b, 4a and 4b) have exhibited both anti-hyperglycemic and anti-dyslipidemic activities. Among them the thiazinan-4-one derivative 4a showed maximal (45%) improvement in oral glucose tolerance test in db/db mice at 30 mg/kg oral dose. (C) 2013 Elsevier Masson SAS. All rights reserved.