L-3-(1H-5-indolyl)alanine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: L-3-(1H-5-indolyl)alanine
• 英文别名: (S)-2-Amino-3-(1H-indol-5-yl)propanoic acid；(2S)-2-amino-3-(1H-indol-5-yl)propanoic acid
• 化学式: C₁₁H₁₂N₂O₂
• 分子量: 204.228
• InChiKey: AYNAZYTXSBGFDA-VIFPVBQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  79.1
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  以 aq. phosphate buffer 为溶剂， 反应 9.0h， 以52%的产率得到L-3-(1H-5-indolyl)alanine
  参考文献：
  名称：

  Negishi 交叉偶联提供烷基化色氨酸和色氨酸区域异构体

  摘要：

  非规范氨基酸。通过钯催化的 Negishi 交叉偶联，可以扩展生物催化卤化色氨酸可能的后期衍生化组合，用于溴代色氨酸的直接烷基化以及从溴代吲哚衍生物合成色氨酸区域异构体。

  DOI：

  10.1002/chem.202103353

文献信息

• THERAPEUTIC PEPTIDES
  申请人：Cohbar Inc.

  公开号：EP3917944A1

  公开（公告）日：2021-12-08
• CYCLIC PEPTIDE INHIBITORS OF HEDGEHOG PROTEINS
  申请人：Fasan Rudi

  公开号：US20190241615A1

  公开（公告）日：2019-08-08

  Cyclic peptide compounds are provided that can bind to one or more homologs of Hedghehog signaling proteins and block their interaction with the Patched receptor. These compounds are useful for suppressing Hedgehog-dependent stimulation of the Hedgehog pathway in cells and in living organisms. Methods for using the cyclic peptide compounds, and compositions comprising them, for treatment of cancers and other diseases which are characterized by aberrant Hedgehog-dependent activation of the Hedgehog pathway and/or which can benefit from chemical suppression of Hedgehog-dependent signaling are also disclosed.
• [EN] THERAPEUTIC PEPTIDES<br/>[FR] PEPTIDES THÉRAPEUTIQUES
  申请人：COHBAR INC

  公开号：WO2020160003A1

  公开（公告）日：2020-08-06

  The disclosures herein relate to the fields of cell biology and the modulation of cellular mechanisms controlling cell viability, cell proliferation, and metabolic processes. More specifically disclosed herein are peptides effective to modulate cellular mechanisms controlling cell viability, cell proliferation, and metabolic processes, including cell signaling associated with aberrant cellular proliferation and malignancy. Also disclosed herein are peptides effective in modulating cellular mechanisms controlling cell viability, treating metabolic diseases, and as cytoprotective agents. Also disclosed are peptides effective in the treatment of fibrosis.
• [EN] THERAPEUTIC MITOCHONDRIAL PEPTIDES<br/>[FR] PEPTIDES MITOCHONDRIAUX THÉRAPEUTIQUES
  申请人：COHBAR INC

  公开号：WO2021030469A1

  公开（公告）日：2021-02-18

  The disclosures herein relate to the fields of cell biology and the modulation of cellular mechanisms controlling cell viability, cell proliferation, and metabolic processes. More specifically disclosed herein are peptides effective to modulate cellular mechanisms controlling cell viability, cell proliferation, and metabolic processes, including cell signaling associated with aberrant cellular proliferation and malignancy. Also disclosed herein are peptides effective in modulating cellular mechanisms controlling cell viability, treating metabolic diseases, and as cytoprotective agents.