2-Propyl-pent-4-enoic acid isopropyl ester | 797753-91-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-Propyl-pent-4-enoic acid isopropyl ester
• 英文别名: Propan-2-yl 2-propylpent-4-enoate
• CAS: 797753-91-4
• 化学式: C₁₁H₂₀O₂
• 分子量: 184.279
• InChiKey: BFVPJWUGHVFOSS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  13
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-Propyl-pent-4-enoic acid isopropyl ester 生成 2-丙基-4-五烯酸
  参考文献：
  名称：

  Examining the correlations between GSK-3 inhibitory properties and anti-convulsant efficacy of valproate and valproate-related compounds

  摘要：

  A family of compounds based upon the chemical structure of valproate were synthesized and assayed for their ability to inhibit glycogen synthase kinase (GSK)-3 alpha and beta activity in vitro. This data is correlated to the known anti-convulsant properties of these compounds in order to determine the potential role of GSK-3 inhibition in the therapeutic efficacy of these drugs. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.09.013
• 作为产物：
  描述：

  戊酸异丙酯 、 3-溴丙烯 在 lithium diisopropyl amide 作用下， 生成 2-Propyl-pent-4-enoic acid isopropyl ester
  参考文献：
  名称：

  Examining the correlations between GSK-3 inhibitory properties and anti-convulsant efficacy of valproate and valproate-related compounds

  摘要：

  A family of compounds based upon the chemical structure of valproate were synthesized and assayed for their ability to inhibit glycogen synthase kinase (GSK)-3 alpha and beta activity in vitro. This data is correlated to the known anti-convulsant properties of these compounds in order to determine the potential role of GSK-3 inhibition in the therapeutic efficacy of these drugs. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.09.013