2,2,2-Trifluoro-N-[3-hydroxy-5-(2,2,2-trifluoro-acetylamino)-phenyl]-acetamide | 164920-99-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,2,2-Trifluoro-N-[3-hydroxy-5-(2,2,2-trifluoro-acetylamino)-phenyl]-acetamide
• 英文别名: 2,2,2-trifluoro-N-[3-hydroxy-5-[(2,2,2-trifluoroacetyl)amino]phenyl]acetamide
• CAS: 164920-99-4
• 化学式: C₁₀H₆F₆N₂O₃
• 分子量: 316.16
• InChiKey: CUTSLKVNKSULTA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  78.4
• 氢给体数：
  3
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  2,2,2-Trifluoro-N-[3-hydroxy-5-(2,2,2-trifluoro-acetylamino)-phenyl]-acetamide 、 分散红 1 在 RO₂CN=NCO₂R 、 三苯基膦 作用下， 以 四氢呋喃 为溶剂， 以55%的产率得到N-[3-(2-{Ethyl-[4-(4-nitro-phenylazo)-phenyl]-amino}-ethoxy)-5-(2,2,2-trifluoro-acetylamino)-phenyl]-2,2,2-trifluoro-acetamide
  参考文献：
  名称：

  The preparation of aromatic NLO amine and diamine monomers for polymerization: A mild Mitsunobu coupling technique for the tethering of sensitive NLO chromophores

  摘要：

  Polymerizable NLO monomers, including those containing highly nonlinear, reagent sensitive chromophores, are prepared under very mild conditions using a deprotection strategy, coupled with Mitsunobu chemistry.

  DOI：

  10.1016/0040-4039(95)00858-a
• 作为产物：
  描述：

  5-[tert-butyl(diphenyl)silyl]oxybenzene-1,3-diamine 、 三氟乙酸酐 在 四丁基氟化铵 作用下， 生成 2,2,2-Trifluoro-N-[3-hydroxy-5-(2,2,2-trifluoro-acetylamino)-phenyl]-acetamide
  参考文献：
  名称：

  The preparation of aromatic NLO amine and diamine monomers for polymerization: A mild Mitsunobu coupling technique for the tethering of sensitive NLO chromophores

  摘要：

  Polymerizable NLO monomers, including those containing highly nonlinear, reagent sensitive chromophores, are prepared under very mild conditions using a deprotection strategy, coupled with Mitsunobu chemistry.

  DOI：

  10.1016/0040-4039(95)00858-a

文献信息

• The preparation of aromatic NLO amine and diamine monomers for polymerization: A mild Mitsunobu coupling technique for the tethering of sensitive NLO chromophores
  作者：R.D. Miller、C. Hawker、V.Y. Lee

  DOI：10.1016/0040-4039(95)00858-a

  日期：1995.6

  Polymerizable NLO monomers, including those containing highly nonlinear, reagent sensitive chromophores, are prepared under very mild conditions using a deprotection strategy, coupled with Mitsunobu chemistry.