Oxalic acid bis-(3,4-dihydro-2H-pyran-2-ylmethyl) ester | 92865-64-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Oxalic acid bis-(3,4-dihydro-2H-pyran-2-ylmethyl) ester
• 英文别名: Bis[(3,4-dihydro-2H-pyran-2-yl)methyl] ethanedioate；bis(3,4-dihydro-2H-pyran-2-ylmethyl) oxalate
• CAS: 92865-64-0
• 化学式: C₁₄H₁₈O₆
• 分子量: 282.293
• InChiKey: MMODPSOFOSVKPO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  71.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-羟甲基-3,4-二氢吡喃 、 草酰氯 在 吡啶 作用下， 以 正己烷 为溶剂， 反应 3.0h， 以74%的产率得到Oxalic acid bis-(3,4-dihydro-2H-pyran-2-ylmethyl) ester
  参考文献：
  名称：

  Synthesis and characterization of polyesters based on 3,4-dihydro-2H-pyran-2-yl-methanol

  摘要：

  Diesters of 3,4-dihydro-2H-pyran-2-yl-methanol with oxalic and phthalic acid were prepared and polymerized. Boron trifluoride etherate, anhydrous ferric chloride, and p-toluene sulfonic acid have been selected as different cationic coinitiators. The resulting polymers can be considered as suitable matrices for controlled drug delivery by in vivo biodegradation. They were characterized and their thermal behaviour was investigated.

  DOI：

  10.1007/bf00844687

文献信息

• Synthesis and characterization of polyesters based on 3,4-dihydro-2H-pyran-2-yl-methanol
  作者：M. Y. Abdelaal、Y. A. Abbas

  DOI：10.1007/bf00844687

  日期：1996.11

  Diesters of 3,4-dihydro-2H-pyran-2-yl-methanol with oxalic and phthalic acid were prepared and polymerized. Boron trifluoride etherate, anhydrous ferric chloride, and p-toluene sulfonic acid have been selected as different cationic coinitiators. The resulting polymers can be considered as suitable matrices for controlled drug delivery by in vivo biodegradation. They were characterized and their thermal behaviour was investigated.