N-[(2-羟基苯基)-(3-硝基苯基)-甲基]-乙酰胺 | 915019-18-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-[(2-羟基苯基)-(3-硝基苯基)-甲基]-乙酰胺
• 英文名称: N-[(2-hydroxyphenyl)(3-nitrophenyl)methyl]acetamide
• 英文别名: N-[(2-Hydroxyphenyl)-(3-nitrophenyl)-methyl]-acetamide；N-[(2-hydroxyphenyl)-(3-nitrophenyl)methyl]acetamide
• CAS: 915019-18-0
• 化学式: C₁₅H₁₄N₂O₄
• 分子量: 286.287
• InChiKey: KYLJJWGBNACZPH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  95.2
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2924299090

反应信息

• 作为反应物：
  描述：

  N-[(2-羟基苯基)-(3-硝基苯基)-甲基]-乙酰胺 、 N,N-二甲基甲酰胺 在 三氯氧磷 作用下， 以81%的产率得到2-[4-(3-Nitrophenyl)-3,4-dihydro-1,3-benzoxazin-2-ylidene]propanedial
  参考文献：
  名称：

  酰胺基烷基萘类的Vilsmeier环化合成高度官能化的恶嗪

  摘要：

  Vilsmeier试剂对酰胺基烷基萘的分子内环化反应产生了1,3-恶嗪。Vilsmeier试剂（氯亚甲基二甲基氯化铵）已被用作一种高效，廉价的酸活化剂，用于一步合成恶嗪衍生物。提出了涉及顺序卤代甲酰基化和分子内亲核环化的机制。

  DOI：

  10.1016/j.tetlet.2009.07.051
• 作为产物：
  描述：

  间硝基苯甲醛 、 乙腈 、 苯酚 在 cerium(IV) sulphate 作用下， 反应 36.0h， 以48%的产率得到N-[(2-羟基苯基)-(3-硝基苯基)-甲基]-乙酰胺
  参考文献：
  名称：

  A new synthesis of acetamido phenols promoted by Ce(SO4)2

  摘要：

  A new method for the synthesis of acetamido phenols by a one-pot, three-component Ritter type reaction in moderate to good yields is described. Both electron donating and electron releasing substitution on aromatic rings are tolerated. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.08.038

文献信息

• Phosphazene-containing polyhexahydrotriazine elastomers
  申请人：International Business Machines Corporation

  公开号：US10584213B2

  公开（公告）日：2020-03-10

  An elastomer, a process for forming an elastomer, and an article of manufacture are disclosed. The elastomer comprises a phosphazene backbone and at least one polyhexahydrotriazine component. The process for forming the elastomer includes obtaining an amine-terminated cyclotriphosphazene, reacting it with a diamine to form a phosphazene-containing PHT polymer, and then reacting the phosphazene-containing PHT polymer with a side-chain modified cyclic phosphazene to form a PCPHT elastomer with halogen ligands. The PCPHT elastomer with halogen ligands is then reacted with an alkoxide to form a PCPHT elastomer with at least one ether-linked side chain. The article of manufacture comprises a material comprising an elastomer having a phosphazene backbone and at least one PHT component.

  本发明公开了一种弹性体、一种形成弹性体的工艺和一种制造品。该弹性体包括膦氮烯骨架和至少一种聚六氢三嗪成分。形成弹性体的工艺包括获得胺封端的环三磷杂蒽，将其与二胺反应形成含磷杂烯的 PHT 聚合物，然后将含磷杂烯的 PHT 聚合物与侧链修饰的环状磷杂蒽反应形成具有卤素配体的 PCPHT 弹性体。带有卤素配位体的 PCPHT 弹性体再与氧化烷反应，形成带有至少一条醚键侧链的 PCPHT 弹性体。制造品包括一种材料，该材料由具有磷苯骨架和至少一种 PHT 成分的弹性体组成。
• A new synthesis of acetamido phenols promoted by Ce(SO4)2
  作者：Nagarajan Panneer Selvam、Paramasivan T. Perumal

  DOI：10.1016/j.tetlet.2006.08.038

  日期：2006.10

  A new method for the synthesis of acetamido phenols by a one-pot, three-component Ritter type reaction in moderate to good yields is described. Both electron donating and electron releasing substitution on aromatic rings are tolerated. (c) 2006 Elsevier Ltd. All rights reserved.
• PHOSPHAZENE-CONTAINING POLYHEXAHYDROTRIAZINE ELASTOMERS
  申请人：International Business Machines Corporation

  公开号：US20200048417A1

  公开（公告）日：2020-02-13

  An elastomer, a process for forming an elastomer, and an article of manufacture are disclosed. The elastomer comprises a phosphazene backbone and at least one polyhexahydrotriazine component. The process for forming the elastomer includes obtaining an amine-terminated cyclotriphosphazene, reacting it with a diamine to form a phosphazene-containing PHT polymer, and then reacting the phosphazene-containing PHT polymer with a side-chain modified cyclic phosphazene to form a PCPHT elastomer with halogen ligands. The PCPHT elastomer with halogen ligands is then reacted with an alkoxide to form a PCPHT elastomer with at least one ether-linked side chain. The article of manufacture comprises a material comprising an elastomer having a phosphazene backbone and at least one PHT component.
• A simple and efficient method for the synthesis of amidophenols using iodine as catalyst under neat condition
  作者：Nagarajan Panneer Selvam、Paramasivan T. Perumal

  DOI：10.1016/j.tet.2008.01.075

  日期：2008.3

  A convenient and efficient one-pot synthesis of substituted amidophenols using iodine as catalyst at room temperature under neat condition is described. (C) 2008 Elsevier Ltd. All rights reserved.
• Synthesis of highly functionalized oxazines by Vilsmeier cyclization of amidoalkyl naphthols
  作者：M. Damodiran、N. Panneer Selvam、Paramasivan T. Perumal

  DOI：10.1016/j.tetlet.2009.07.051

  日期：2009.9

  The intramolecular cyclization of amidoalkyl naphthols by Vilsmeier reagent produced 1,3-oxazines. The Vilsmeier reagent (chloromethylenedimethylammonium chloride) has been used as an efficient and cheap acid activator for the one-step synthesis of oxazine derivatives. A mechanism involving sequential haloformylation and intramolecular nucleophilic cyclization is proposed.

  Vilsmeier试剂对酰胺基烷基萘的分子内环化反应产生了1,3-恶嗪。Vilsmeier试剂（氯亚甲基二甲基氯化铵）已被用作一种高效，廉价的酸活化剂，用于一步合成恶嗪衍生物。提出了涉及顺序卤代甲酰基化和分子内亲核环化的机制。